Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 24 件

6LHM
DownloadVisualize
BU of 6lhm by Molmil
Structure of human PYCR2
分子名称: Pyrroline-5-carboxylate reductase 2
著者Baburajendran, N.
登録日2019-12-09
公開日2020-10-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Neuron, 107, 2020
3KMP
DownloadVisualize
BU of 3kmp by Molmil
Crystal Structure of SMAD1-MH1/DNA complex
分子名称: 5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A)-3', 5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A)-3', GLYCEROL, ...
著者Baburajendran, N, Palasingam, P, Narasimhan, K, Jauch, R, Kolatkar, P.R.
登録日2009-11-11
公開日2010-02-23
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors.
Nucleic Acids Res., 38, 2010
3QSV
DownloadVisualize
BU of 3qsv by Molmil
Structural basis for DNA recognition by constitutive Smad4 MH1 dimers
分子名称: DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*CP*A)-3'), Mothers against decapentaplegic homolog 4, ZINC ION
著者Baburajendran, N, Jauch, R, Zhen, C.T.Y, Kolatkar, P.R.
登録日2011-02-22
公開日2011-06-22
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.708 Å)
主引用文献Structural basis for DNA recognition by constitutive Smad4 MH1 dimers
To be Published
6ILZ
DownloadVisualize
BU of 6ilz by Molmil
Crystal structure of PKCiota in complex with inhibitor
分子名称: 2-amino-5-[3-(piperazin-1-yl)phenyl]-N-(pyridin-4-yl)pyridine-3-carboxamide, Protein kinase C iota type
著者Baburajendran, N, Hill, J.
登録日2018-10-21
公開日2019-06-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.261 Å)
主引用文献Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues.
Acs Med.Chem.Lett., 10, 2019
6JLR
DownloadVisualize
BU of 6jlr by Molmil
Crystal structure of wild type MNK2 in complex with inhibitor
分子名称: 4-[5-(1-methylpyrazol-4-yl)pyridin-3-yl]benzamide, MAP kinase-interacting serine/threonine-protein kinase 2
著者Baburajendran, N, Hill, J.
登録日2019-03-06
公開日2020-02-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.
J.Med.Chem., 63, 2020
6IJL
DownloadVisualize
BU of 6ijl by Molmil
Crystal structure of SmyD3 in complex with covalent inhibitor 5
分子名称: Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ZINC ION, ...
著者Baburajendran, N, Joy, J.
登録日2018-10-10
公開日2019-08-14
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.351 Å)
主引用文献Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.
Acs Med.Chem.Lett., 10, 2019
5YJO
DownloadVisualize
BU of 5yjo by Molmil
Crystal structure of SmyD3 in complex with covalent inhibitor 4
分子名称: Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ZINC ION, ...
著者Baburajendran, N, Anna E, J.
登録日2017-10-11
公開日2018-10-17
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.135 Å)
主引用文献Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.
Acs Med.Chem.Lett., 10, 2019
5XXD
DownloadVisualize
BU of 5xxd by Molmil
Crystal structure of SmyD3 in complex with covalent inhibitor 1
分子名称: S-ADENOSYLMETHIONINE, Smyd3 methyltransferase, ZINC ION, ...
著者Baburajendran, N, Anna E, J.
登録日2017-07-03
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.314 Å)
主引用文献Crystal structure of SmyD3 in complex with covalent inhibitor 1
To Be Published
5XXJ
DownloadVisualize
BU of 5xxj by Molmil
Crystal structure of SmyD3 in complex with covalent inhibitor 3
分子名称: S-ADENOSYLMETHIONINE, SMYD3, ZINC ION, ...
著者Baburajendran, N, Jansson, A.E.
登録日2017-07-04
公開日2018-08-08
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.689 Å)
主引用文献Crystal structure of SmyD3 in complex with covalent inhibitor 3
To Be Published
5XXG
DownloadVisualize
BU of 5xxg by Molmil
Crystal structure of SmyD3 in complex with covalent inhibitor 2
分子名称: S-ADENOSYLMETHIONINE, SMYD3, ZINC ION, ...
著者Baburajendran, N, Jansson, E.A.
登録日2017-07-03
公開日2018-08-08
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Crystal structure of SmyD3 in complex with covalent inhibitor 2
To Be Published
5ZJS
DownloadVisualize
BU of 5zjs by Molmil
Structure of AbdB/Exd complex bound to a 'Blue14' DNA sequence
分子名称: DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*TP*AP*AP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*TP*TP*AP*AP*TP*CP*AP*TP*GP*C)-3'), Homeobox protein abdominal-B, ...
著者Baburajendran, N, Zeiske, T, Kaczynska, A, Mann, R, Honig, B, Shapiro, L, Palmer, A.G.
登録日2018-03-22
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.896 Å)
主引用文献Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites.
Cell Rep, 24, 2018
5ZJQ
DownloadVisualize
BU of 5zjq by Molmil
Structure of AbdB/Exd complex bound to a 'Red14' DNA sequence
分子名称: DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*TP*TP*AP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*TP*AP*AP*AP*TP*CP*AP*TP*GP*C)-3'), Homeobox protein abdominal-B, ...
著者Baburajendran, N, Zeiske, T, Kaczynska, A, Mann, R, Honig, B, Shapiro, L, Palmer, A.G.
登録日2018-03-22
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.443 Å)
主引用文献Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites.
Cell Rep, 24, 2018
4E6S
DownloadVisualize
BU of 4e6s by Molmil
Crystal structure of the SCAN domain from mouse Zfp206
分子名称: Zinc finger and SCAN domain-containing protein 10
著者Liang, Y, Choo, S.H, Rossbach, M, Baburajendran, N, Palasingam, P, Kolatkar, P.R.
登録日2012-03-15
公開日2012-05-02
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206.
Acta Crystallogr.,Sect.F, 68, 2012
8JVE
DownloadVisualize
BU of 8jve by Molmil
Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer
分子名称: 1,2-ETHANEDIOL, 1-(3-methoxyphenyl)-1,2,3,4-tetrazole, Ubiquitin-conjugating enzyme E2 T
著者Anantharajan, J, Baburajendran, N.
登録日2023-06-28
公開日2023-11-29
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer.
Biochem.Biophys.Res.Commun., 689, 2023
8JVL
DownloadVisualize
BU of 8jvl by Molmil
Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer
分子名称: 1,2-ETHANEDIOL, 1-(4-methoxyphenyl)-1,2,3,4-tetrazole, Ubiquitin-conjugating enzyme E2 T
著者Anantharajan, J, Baburajendran, N.
登録日2023-06-28
公開日2023-11-29
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer.
Biochem.Biophys.Res.Commun., 689, 2023
8JVD
DownloadVisualize
BU of 8jvd by Molmil
Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening
分子名称: 5-fluoranyl-1,3-benzoxazol-2-amine, Ubiquitin-conjugating enzyme E2 T
著者Anantharajan, J, Baburajendran, N.
登録日2023-06-28
公開日2024-02-28
実験手法X-RAY DIFFRACTION (1.696 Å)
主引用文献Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening.
Protein Sci., 33, 2024
8JUC
DownloadVisualize
BU of 8juc by Molmil
Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening
分子名称: 1,2-ETHANEDIOL, 7-methyl-2-(trifluoromethyl)-3~{H}-[1,2,4]triazolo[1,5-a]pyridin-5-one, Ubiquitin-conjugating enzyme E2 T
著者Anantharajan, J, Baburajendran, N.
登録日2023-06-26
公開日2024-02-28
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening.
Protein Sci., 33, 2024
7CC2
DownloadVisualize
BU of 7cc2 by Molmil
Strategic design of catalytic lysine-targeting reversible covalent BCR-ABL Inhibitors
分子名称: Tyrosine-protein kinase ABL1, [4-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methyl-phenyl]boronic acid
著者Anantharajan, J, Baburajendran, N.
登録日2020-06-16
公開日2021-06-09
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.723 Å)
主引用文献Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors*.
Angew.Chem.Int.Ed.Engl., 60, 2021
7DT2
DownloadVisualize
BU of 7dt2 by Molmil
Strategic design of catalytic lysine-targeting reversible covalent BCR-ABL Inhibitors
分子名称: Tyrosine-protein kinase ABL1, [4-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methanoyl-5-methoxy-phenyl]boronic acid
著者Anantharajan, J, Baburajendran, N.
登録日2021-01-04
公開日2021-06-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors*.
Angew.Chem.Int.Ed.Engl., 60, 2021
7DXL
DownloadVisualize
BU of 7dxl by Molmil
Fragment-based Lead Discovery of Indazole-based Compounds as AXL Kinase Inhibitors
分子名称: 3-[4-[6-chloranyl-5-[[(3R)-pyrrolidin-3-yl]amino]-1H-indazol-3-yl]pyrazol-1-yl]benzenecarbonitrile, Tyrosine-protein kinase Mer
著者Anantharajan, J, Baburajendran, N.
登録日2021-01-19
公開日2021-10-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.146 Å)
主引用文献Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.
Bioorg.Med.Chem., 49, 2021
7F8G
DownloadVisualize
BU of 7f8g by Molmil
Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase
分子名称: 3-phenoxy-~{N}-[(~{E})-(5-pyrimidin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide, Eyes absent homolog 2
著者Anantharajan, J, Baburajendran, N.
登録日2021-07-02
公開日2021-12-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.491 Å)
主引用文献Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase.
Protein Sci., 31, 2022
7F8H
DownloadVisualize
BU of 7f8h by Molmil
Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase
分子名称: 3-fluoranyl-~{N}-[(~{E})-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide, Eyes absent homolog 2
著者Anantharajan, J, Baburajendran, N.
登録日2021-07-02
公開日2021-12-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase.
Protein Sci., 31, 2022
5ZJT
DownloadVisualize
BU of 5zjt by Molmil
Structure of AbdB/Exd complex bound to a 'Black14' DNA sequence
分子名称: DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*AP*AP*AP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*TP*TP*TP*AP*TP*CP*AP*TP*GP*C)-3'), Homeobox protein abdominal-B, ...
著者Zeiske, T, Baburajendran, N, Kaczynska, A, Mann, R, Honig, B, Shapiro, L, Palmer, A.G.
登録日2018-03-22
公開日2018-08-29
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites.
Cell Rep, 24, 2018
5ZJR
DownloadVisualize
BU of 5zjr by Molmil
Structure of AbdB/Exd complex bound to a 'Magenta14' DNA sequence
分子名称: DNA (5'-D(*GP*TP*CP*GP*TP*AP*AP*AP*TP*CP*AP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*AP*C)-3'), Homeobox protein abdominal-B, ...
著者Zeiske, T, Baburajendran, N, Kaczynska, A, Mann, R, Honig, B, Shapiro, L, Palmer, A.G.
登録日2018-03-22
公開日2018-08-29
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites.
Cell Rep, 24, 2018

227111

件を2024-11-06に公開中

PDB statisticsPDBj update infoContact PDBjnumon