5SWT
| Crystal Structure of PI3Kalpha in complex with fragments 17 and 27 | 分子名称: | 3-fluoro-4-methoxyaniline, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | 著者 | Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M. | 登録日 | 2016-08-08 | 公開日 | 2017-02-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design. Bioorg. Med. Chem., 25, 2017
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5SXC
| Crystal Structure of PI3Kalpha in complex with fragment 8 | 分子名称: | 5-FLUOROURACIL, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M. | 登録日 | 2016-08-09 | 公開日 | 2017-02-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | 主引用文献 | Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design. Bioorg. Med. Chem., 25, 2017
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5SX8
| Crystal Structure of PI3Kalpha in complex with fragments 12 and 15 | 分子名称: | 6-methylpyridin-2-amine, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | 著者 | Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M. | 登録日 | 2016-08-09 | 公開日 | 2017-02-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.47 Å) | 主引用文献 | Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design. Bioorg. Med. Chem., 25, 2017
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5SXJ
| Crystal Structure of PI3Kalpha in complex with fragment 29 | 分子名称: | BENZHYDROXAMIC ACID, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M. | 登録日 | 2016-08-09 | 公開日 | 2017-02-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | 主引用文献 | Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design. Bioorg. Med. Chem., 25, 2017
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5SXF
| Crystal Structure of PI3Kalpha in complex with fragment 9 | 分子名称: | HYDROXYPHENYL PROPIONIC ACID, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M. | 登録日 | 2016-08-09 | 公開日 | 2017-02-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.46 Å) | 主引用文献 | Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design. Bioorg. Med. Chem., 25, 2017
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5SXK
| Crystal Structure of PI3Kalpha in complex with fragment 18 | 分子名称: | 2-methylbenzene-1,3-diamine, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M. | 登録日 | 2016-08-09 | 公開日 | 2017-02-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | 主引用文献 | Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design. Bioorg. Med. Chem., 25, 2017
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3MIF
| Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound carbon monooxide (CO) | 分子名称: | CARBON MONOXIDE, COPPER (II) ION, GLYCEROL, ... | 著者 | Siebert, X, Chufan, E, Eipper, B.A, Mains, R.E, Amzel, L.M. | 登録日 | 2010-04-10 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Differential Reactivity Between the Two Copper Sites of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) J.Am.Chem.Soc., 132, 2010
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3MLL
| Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide | 分子名称: | AZIDE ION, COPPER (II) ION, NICKEL (II) ION, ... | 著者 | Chufan, E.E, Eipper, B.A, Mains, R.E, Amzel, L.M. | 登録日 | 2010-04-16 | 公開日 | 2011-03-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Differential reactivity between two copper sites in peptidylglycine alpha-hydroxylating monooxygenase J.Am.Chem.Soc., 132, 2010
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3MIC
| Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide obtained by co-crystallization | 分子名称: | AZIDE ION, COPPER (II) ION, GLYCEROL, ... | 著者 | Chufan, E.E, Eipper, B.A, Mains, R.E, Amzel, L.M. | 登録日 | 2010-04-10 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Differential Reactivity Between the Two Copper Sites of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) J.Am.Chem.Soc., 132, 2010
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3MIB
| Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound nitrite | 分子名称: | COPPER (II) ION, GLYCEROL, NICKEL (II) ION, ... | 著者 | Chufan, E.E, Eipper, B.A, Mains, R.E, Amzel, L.M. | 登録日 | 2010-04-10 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Differential Reactivity Between the Two Copper Sites of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) J.Am.Chem.Soc., 132, 2010
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3MIE
| Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide obtained by soaking (50mM NaN3) | 分子名称: | AZIDE ION, COPPER (II) ION, GLYCEROL, ... | 著者 | Chufan, E.E, Eipper, B.A, Mains, R.E, Amzel, L.M. | 登録日 | 2010-04-10 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | 主引用文献 | Differential Reactivity Between the Two Copper Sites of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) J.Am.Chem.Soc., 132, 2010
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3MID
| Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide obtained by soaking (100mM NaN3) | 分子名称: | AZIDE ION, COPPER (II) ION, GLYCEROL, ... | 著者 | Chufan, E.E, Eipper, B.A, Mains, R.E, Amzel, L.M. | 登録日 | 2010-04-10 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | Differential Reactivity Between the Two Copper Sites of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) J.Am.Chem.Soc., 132, 2010
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3MIH
| Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide, obtained in the presence of substrate | 分子名称: | AZIDE ION, COPPER (II) ION, IODIDE ION, ... | 著者 | Chufan, E.E, Eipper, B.A, Mains, R.E, Amzel, L.M. | 登録日 | 2010-04-10 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Differential Reactivity Between the Two Copper Sites of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) J.Am.Chem.Soc., 132, 2010
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3MLK
| Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound nitrite | 分子名称: | COPPER (II) ION, NICKEL (II) ION, NITRITE ION, ... | 著者 | Chufan, E.E, Eipper, B.A, Mains, R.E, Amzel, L.M. | 登録日 | 2010-04-16 | 公開日 | 2011-03-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Differential reactivity between two copper sites in peptidylglycine alpha-hydroxylating monooxygenase J.Am.Chem.Soc., 132, 2010
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3MLJ
| Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound carbon monooxide (CO) | 分子名称: | ACETATE ION, CARBON MONOXIDE, COPPER (II) ION, ... | 著者 | Prigge, S.T, Chufan, E.E, Eipper, B.A, Mains, R.E, Amzel, L.M. | 登録日 | 2010-04-16 | 公開日 | 2011-03-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Differential reactivity between two copper sites in peptidylglycine alpha-hydroxylating monooxygenase J.Am.Chem.Soc., 132, 2010
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3MIG
| Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound nitrite, obtained in the presence of substrate | 分子名称: | COPPER (II) ION, GLYCEROL, NICKEL (II) ION, ... | 著者 | Chufan, E.E, Eipper, B.A, Mains, R.E, Amzel, L.M. | 登録日 | 2010-04-10 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Differential Reactivity Between the Two Copper Sites of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) J.Am.Chem.Soc., 132, 2010
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3MSV
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3NLS
| Crystal Structure of HIV-1 Protease in Complex with KNI-10772 | 分子名称: | (4R)-3-[(2R,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H- inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Gabelli, S.B, Kawasaki, Y, Freire, E, Amzel, L.M. | 登録日 | 2010-06-21 | 公開日 | 2011-09-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure of HIV-1 Protease in Complex with KNI-10772 To be Published
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3NPE
| Structure of VP14 in complex with oxygen | 分子名称: | 1,4-DIETHYLENE DIOXIDE, 9-cis-epoxycarotenoid dioxygenase 1, chloroplastic, ... | 著者 | Messing, S.A, Gabelli, S.B, Amzel, L.M. | 登録日 | 2010-06-28 | 公開日 | 2010-11-10 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid. Plant Cell, 22, 2010
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3D62
| Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro | 分子名称: | 3C-like proteinase, benzyl (2-oxopropyl)carbamate | 著者 | Bacha, U, Barrila, J, Gabelli, S.B, Kiso, Y, Amzel, L.M, Freire, E. | 登録日 | 2008-05-18 | 公開日 | 2008-07-01 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chem.Biol.Drug Des., 72, 2008
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3KDB
| Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10006 | 分子名称: | (4R)-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, GLYCEROL, Protease | 著者 | Chufan, E.E, Lafont, V, Freire, E, Amzel, L.M. | 登録日 | 2009-10-22 | 公開日 | 2010-03-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | How much binding affinity can be gained by filling a cavity? Chem.Biol.Drug Des., 75, 2010
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3KDC
| Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10074 | 分子名称: | (4R)-3-[(2S,3S)-3-{[(2,6-dichlorophenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, CHLORIDE ION, GLYCEROL, ... | 著者 | Chufan, E.E, Kawasaki, Y, Freire, E, Amzel, L.M. | 登録日 | 2009-10-22 | 公開日 | 2010-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | How much binding affinity can be gained by filling a cavity? Chem.Biol.Drug Des., 75, 2010
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3KDD
| Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10265 | 分子名称: | (4R)-3-[(2S,3S)-3-{[(2,6-difluorophenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H- inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, GLYCEROL, Protease | 著者 | Chufan, E.E, Kawasaki, Y, Freire, E, Amzel, L.M. | 登録日 | 2009-10-22 | 公開日 | 2010-03-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | How much binding affinity can be gained by filling a cavity? Chem.Biol.Drug Des., 75, 2010
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