4WGK
 
 | | Crystal structure of human neutral ceramidase with Zn-bound phosphate | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Airola, M.V, Pulkoski-Gross, M.J, Obeid, L.M, Hannun, Y.A. | | Deposit date: | 2014-09-18 | | Release date: | 2015-07-08 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.582 Å) | | Cite: | Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.
Structure, 23, 2015
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3LNR
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5UVG
 | | Crystal structure of the human neutral sphingomyelinase 2 (nSMase2) catalytic domain with insertion deleted and calcium bound | | Descriptor: | CALCIUM ION, Sphingomyelin phosphodiesterase 3,Sphingomyelin phosphodiesterase 3 | | Authors: | Airola, M.V, Guja, K.E, Garcia-Diaz, M, Hannun, Y.A. | | Deposit date: | 2017-02-20 | | Release date: | 2017-06-28 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.849 Å) | | Cite: | Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4HI4
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4I44
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4I3M
 | | Aer2 poly-HAMP domains: L44H HAMP1 CW-lock mutant | | Descriptor: | Aerotaxis transducer Aer2, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Airola, M.V, Sukomon, N, Crane, B.R. | | Deposit date: | 2012-11-26 | | Release date: | 2013-02-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | HAMP Domain Conformers That Propagate Opposite Signals in Bacterial Chemoreceptors.
Plos Biol., 11, 2013
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7LHK
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8EXD
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8UJM
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8UJL
 | | Crystal structure of human CTDNEP1-NEP1R1 protein phosphatase complex | | Descriptor: | CTD nuclear envelope phosphatase 1,Nuclear envelope phosphatase-regulatory subunit 1 | | Authors: | Gao, S, Airola, M.V. | | Deposit date: | 2023-10-11 | | Release date: | 2024-05-15 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Structure and mechanism of the human CTDNEP1-NEP1R1 membrane protein phosphatase complex necessary to maintain ER membrane morphology.
Proc.Natl.Acad.Sci.USA, 121, 2024
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6TZZ
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6TZY
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6U8Z
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7KIL
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7KIQ
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7KIH
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7LPQ
 | | Crystal structure of Cryptococcus neoformans sterylglucosidase 1 with hit 9 | | Descriptor: | Cytoplasmic protein, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Pereira de Sa, N, Del Poeta, M, Airola, M.V. | | Deposit date: | 2021-02-12 | | Release date: | 2021-09-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents.
Nat Commun, 12, 2021
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7LPP
 | | Crystal structure of Cryptococcus neoformans sterylglucosidase 1 with hit 1 | | Descriptor: | 4-(hydroxymethyl)-1-[[2-(3-methoxyphenyl)-1,3-thiazol-5-yl]methyl]piperidin-4-ol, Cytoplasmic protein, GLYCEROL, ... | | Authors: | Pereira de Sa, N, Del Poeta, M, Airola, M.V. | | Deposit date: | 2021-02-12 | | Release date: | 2021-09-01 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents.
Nat Commun, 12, 2021
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7LPO
 | | Crystal structure of Cryptococcus neoformans sterylglucosidase 1 with tris | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cytoplasmic protein, MAGNESIUM ION | | Authors: | Pereira de Sa, N, Del Poeta, M, Airola, M.V. | | Deposit date: | 2021-02-12 | | Release date: | 2021-09-01 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents.
Nat Commun, 12, 2021
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