7M7V
| Crystal Structure of Mtb Pks13 Thioesterase domain in complex with Compound 6 | Descriptor: | 5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-[(2-oxa-6-azaspiro[3.4]octan-6-yl)methyl]-1-benzofuran-3-carboxamide, Polyketide synthase Pks13 | Authors: | Aggarwal, A, Sacchettini, J.C. | Deposit date: | 2021-03-29 | Release date: | 2022-02-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. J.Med.Chem., 65, 2022
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1BAM
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1BHM
| RESTRICTION ENDONUCLEASE BAMHI COMPLEX WITH DNA | Descriptor: | DNA (5'-D(*TP*AP*TP*GP*GP*AP*TP*CP*CP*AP*TP*A)-3'), PROTEIN (BAMHI (E.C.3.1.21.4)) | Authors: | Aggarwal, A.K, Newman, M. | Deposit date: | 1995-07-12 | Release date: | 1995-07-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of Bam HI endonuclease bound to DNA: partial folding and unfolding on DNA binding. Science, 269, 1995
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2OR1
| RECOGNITION OF A DNA OPERATOR BY THE REPRESSOR OF PHAGE 434. A VIEW AT HIGH RESOLUTION | Descriptor: | 434 REPRESSOR, DNA (5'-D(*AP*AP*GP*TP*AP*CP*AP*AP*AP*CP*TP*TP*TP*CP*TP*TP*G P*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*CP*AP*AP*GP*AP*AP*AP*GP*TP*TP*TP*GP*T P*AP*CP*T)-3') | Authors: | Aggarwal, A.K, Rodgers, D.W, Drottar, M, Ptashne, M, Harrison, S.C. | Deposit date: | 1989-09-05 | Release date: | 1989-09-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Recognition of a DNA operator by the repressor of phage 434: a view at high resolution. Science, 242, 1988
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2EZV
| Crystal structure of tetrameric restriction endonuclease SfiI bound to cognate DNA. | Descriptor: | 5'-D(*AP*GP*GP*CP*CP*TP*TP*GP*TP*TP*GP*GP*CP*CP*A)-3', 5'-D(*TP*GP*GP*CP*CP*AP*AP*CP*AP*AP*GP*GP*CP*CP*T)-3', CALCIUM ION, ... | Authors: | Aggarwal, A.K, Vanamee, E.S, Viadiu, H. | Deposit date: | 2005-11-10 | Release date: | 2006-01-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A view of consecutive binding events from structures of tetrameric endonuclease SfiI bound to DNA Embo J., 24, 2005
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2R5Y
| Structure of Scr/Exd complex bound to a consensus Hox-Exd site | Descriptor: | DNA (5'-D(*DAP*DCP*DTP*DCP*DTP*DAP*DTP*DGP*DAP*DTP*DTP*DTP*DAP*DTP*DGP*DGP*DGP*DCP*DTP*DG)-3'), DNA (5'-D(*DTP*DCP*DAP*DGP*DCP*DCP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DCP*DAP*DTP*DAP*DGP*DAP*DG)-3'), Homeobox protein extradenticle, ... | Authors: | Aggarwal, A.K, Passner, J.M, Jain, R. | Deposit date: | 2007-09-04 | Release date: | 2008-02-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Functional specificity of a Hox protein mediated by the recognition of minor groove structure Cell(Cambridge,Mass.), 131, 2007
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2R5Z
| Structure of Scr/Exd complex bound to a DNA sequence derived from the fkh gene | Descriptor: | DNA (5'-D(*DAP*DCP*DTP*DCP*DTP*DAP*DAP*DGP*DAP*DTP*DTP*DAP*DAP*DTP*DCP*DGP*DGP*DCP*DTP*DG)-3'), DNA (5'-D(*DTP*DCP*DAP*DGP*DCP*DCP*DGP*DAP*DTP*DTP*DAP*DAP*DTP*DCP*DTP*DTP*DAP*DGP*DAP*DG)-3'), Homeobox protein extradenticle, ... | Authors: | Aggarwal, A.K, Passner, J.M, Jain, R. | Deposit date: | 2007-09-04 | Release date: | 2008-02-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Functional specificity of a Hox protein mediated by the recognition of minor groove structure Cell(Cambridge,Mass.), 131, 2007
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2F03
| Crystal structure of tetrameric restriction endonuclease SfiI in complex with cognate DNA (partial bound form) | Descriptor: | CALCIUM ION, DNA (5'-D(*AP*AP*TP*AP*GP*GP*CP*CP*TP*TP*GP*TP*TP*GP*GP*CP*CP*AP*CP*AP*T)-3'), DNA (5'-D(*AP*TP*G*TP*GP*GP*CP*CP*AP*AP*CP*AP*AP*GP*GP*CP*CP*TP*AP*TP*T)-3'), ... | Authors: | Aggarwal, A.K, Vanamee, E.S, Viadiu, H | Deposit date: | 2005-11-11 | Release date: | 2007-01-16 | Last modified: | 2015-09-09 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | A view of consecutive binding events from structures of tetrameric endonuclease SfiI bound to DNA. Embo J., 24, 2005
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5V41
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5V3W
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5V42
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5V3Y
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5V3Z
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5V3X
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5V40
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6UWA
| Mouse PKC C1B and C2 domains | Descriptor: | CITRIC ACID, LEAD (II) ION, Protein kinase C, ... | Authors: | Aggarwal, A, Mire, J, Sacchettini, J.C, Igumenova, T. | Deposit date: | 2019-11-04 | Release date: | 2020-12-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Mouse PKC C1B and C2 domains To Be Published
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3BAM
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2P0J
| Structure of restriction endonuclease BstYI bound to non-cognate DNA | Descriptor: | 5'-D(*AP*TP*GP*AP*AP*TP*CP*CP*AP*TP*A)-3', 5'-D(*TP*AP*TP*GP*GP*AP*TP*TP*CP*AP*T)-3', BstYI | Authors: | Townson, S.A, Samuelson, J.C, Bao, Y, Xu, S.Y, Aggarwal, A.K. | Deposit date: | 2007-02-28 | Release date: | 2007-05-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | BstYI Bound to Noncognate DNA Reveals a "Hemispecific" Complex: Implications for DNA Scanning. Structure, 15, 2007
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9C3T
| Crystal structure of DNA N6-Adenine Methyltransferase M.BceJIV from Burkholderia cenocepacia in complex with duplex DNA substrate containing GTAAAC as recognition sequence | Descriptor: | DNA1, DNA2, Methyltransferase, ... | Authors: | Kottur, J, Quintana-Feliciano, R, Aggarwal, A.K. | Deposit date: | 2024-06-02 | Release date: | 2024-09-11 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation. Nat Commun, 15, 2024
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9C3U
| Crystal structure of DNA N6-Adenine Methyltransferase M.BceJIV from Burkholderia cenocepacia in complex with duplex DNA substrate containing GTTTAC as recognition sequence | Descriptor: | DNA1, DNA2, Methyltransferase, ... | Authors: | Kottur, J, Quintana-Feliciano, R, Aggarwal, A.K. | Deposit date: | 2024-06-02 | Release date: | 2024-09-11 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation. Nat Commun, 15, 2024
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9C3S
| Crystal structure of DNA N6-Adenine Methyltransferase M.BceJIV from Burkholderia cenocepacia in complex with duplex DNA substrate containing GTATAC as recognition sequence | Descriptor: | DNA1, DNA2, Methyltransferase, ... | Authors: | Kottur, J, Quintana-Feliciano, R, Aggarwal, A.K. | Deposit date: | 2024-06-02 | Release date: | 2024-09-11 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation. Nat Commun, 15, 2024
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2PI0
| Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer | Descriptor: | Interferon regulatory factor 3, PRDIII-I region of human interferon-B promoter strand 1, PRDIII-I region of human interferon-B promoter strand 2 | Authors: | Escalante, C.R, Nistal-Villan, E, Leyi, S, Garcia-Sastre, A, Aggarwal, A.K. | Deposit date: | 2007-04-12 | Release date: | 2007-10-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. Mol.Cell, 26, 2007
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7M5B
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7M5C
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7M5A
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