7UOS
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![BU of 7uos by Molmil](/molmil-images/mine/7uos) | Structure of WNK1 inhibitor complex | Descriptor: | 1,2-ETHANEDIOL, 4-[bromo(dichloro)methanesulfonyl]-N-cyclohexyl-2-nitroaniline, Serine/threonine-protein kinase WNK1 | Authors: | Akella, R, Goldsmith, E.J, Akella, R. | Deposit date: | 2022-04-13 | Release date: | 2023-04-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of WNK1 inhibitor complex To Be Published
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8EDH
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![BU of 8edh by Molmil](/molmil-images/mine/8edh) | |
3P4K
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![BU of 3p4k by Molmil](/molmil-images/mine/3p4k) | The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution | Descriptor: | MAP kinase 14, Mitogen-activated protein kinase 14 | Authors: | Akella, R, Min, X, Wu, Q, Gardner, K.H, Goldsmith, E.J. | Deposit date: | 2010-10-06 | Release date: | 2011-01-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution Structure, 18, 2010
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6CN9
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![BU of 6cn9 by Molmil](/molmil-images/mine/6cn9) | Crystal structure of the Kinase domain of WNK1 | Descriptor: | GLYCEROL, SULFATE ION, Serine/threonine-protein kinase WNK1 | Authors: | Akella, R, Goldsmith, E.J. | Deposit date: | 2018-03-07 | Release date: | 2019-03-27 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure, 12, 2004
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6OL2
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![BU of 6ol2 by Molmil](/molmil-images/mine/6ol2) | Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening | Descriptor: | ACETATE ION, GLYCEROL, N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide, ... | Authors: | Chlebowicz, J, Akella, R, Sekulski, K, Humphreys, J.M, Durbacz, M.Z, He, H, Rodan, A, Posner, B, Goldsmith, E.J. | Deposit date: | 2019-04-15 | Release date: | 2020-04-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystallography of novel WNK1 and WNK3 inhibitors discovered from high throughput screening To Be Published
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5W7T
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3ENM
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![BU of 3enm by Molmil](/molmil-images/mine/3enm) | The structure of the MAP2K MEK6 reveals an autoinhibitory dimer | Descriptor: | 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 6, GLYCEROL, ... | Authors: | Min, X, Akella, R, He, H, Humphreys, J.M, Tsutakawa, S, Lee, S.-J, Tainer, J.A, Cobb, M.H, Goldsmith, E.J. | Deposit date: | 2008-09-25 | Release date: | 2009-03-03 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The structure of the MAP2K MEK6 reveals an autoinhibitory dimer Structure, 17, 2009
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2NV9
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![BU of 2nv9 by Molmil](/molmil-images/mine/2nv9) | The X-ray Crystal Structure of the Paramecium bursaria Chlorella virus arginine decarboxylase | Descriptor: | A207R protein, arginine decarboxylase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Shah, R.H, Akella, R, Goldsmith, E, Phillips, M.A. | Deposit date: | 2006-11-11 | Release date: | 2007-03-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity. Biochemistry, 46, 2007
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2NVA
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![BU of 2nva by Molmil](/molmil-images/mine/2nva) | The X-ray crystal structure of the Paramecium bursaria Chlorella virus arginine decarboxylase bound to agmatine | Descriptor: | (4-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, arginine decarboxylase, A207R protein | Authors: | Shah, R.H, Akella, R, Goldsmith, E, Phillips, M.A. | Deposit date: | 2006-11-11 | Release date: | 2007-03-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity. Biochemistry, 46, 2007
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4Q2A
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![BU of 4q2a by Molmil](/molmil-images/mine/4q2a) | WNK1: A chloride sensor via autophosphorylation | Descriptor: | BROMIDE ION, Serine/threonine-protein kinase WNK1 | Authors: | Piala, A, Moon, T, Akella, R, He, H, Cobb, M.H, Goldsmith, E. | Deposit date: | 2014-04-07 | Release date: | 2014-05-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation. Sci.Signal., 7, 2014
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1LEW
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![BU of 1lew by Molmil](/molmil-images/mine/1lew) | CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A | Descriptor: | Mitogen-activated protein kinase 14, Myocyte-specific enhancer factor 2A | Authors: | Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J. | Deposit date: | 2002-04-10 | Release date: | 2002-07-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol.Cell, 9, 2002
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1LEZ
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![BU of 1lez by Molmil](/molmil-images/mine/1lez) | CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B | Descriptor: | MAP kinase kinase 3b, MITOGEN-ACTIVATED PROTEIN KINASE 14 | Authors: | Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J. | Deposit date: | 2002-04-10 | Release date: | 2002-07-10 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol.Cell, 9, 2002
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