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PDB: 12 件
7UOS
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BU of 7uos by Molmil
Structure of WNK1 inhibitor complex
分子名称: 1,2-ETHANEDIOL, 4-[bromo(dichloro)methanesulfonyl]-N-cyclohexyl-2-nitroaniline, Serine/threonine-protein kinase WNK1
著者Akella, R, Goldsmith, E.J, Akella, R.
登録日2022-04-13
公開日2023-04-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of WNK1 inhibitor complex
To Be Published
8EDH
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Identification of a class of WNK isoform-specific inhibitors through high-throughput screening
分子名称: Serine/threonine-protein kinase WNK3, ethyl 1-(5,7-dimethoxy-4-methylquinolin-2-yl)piperidine-4-carboxylate
著者Akella, R, Goldsmith, E.J.
登録日2022-09-04
公開日2023-03-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.111 Å)
主引用文献Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening.
Drug Des Devel Ther, 17, 2023
3P4K
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BU of 3p4k by Molmil
The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution
分子名称: MAP kinase 14, Mitogen-activated protein kinase 14
著者Akella, R, Min, X, Wu, Q, Gardner, K.H, Goldsmith, E.J.
登録日2010-10-06
公開日2011-01-05
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.304 Å)
主引用文献The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution
Structure, 18, 2010
6CN9
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Crystal structure of the Kinase domain of WNK1
分子名称: GLYCEROL, SULFATE ION, Serine/threonine-protein kinase WNK1
著者Akella, R, Goldsmith, E.J.
登録日2018-03-07
公開日2019-03-27
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.
Structure, 12, 2004
5W7T
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STRUCTURE OF PHOSPHORYLATED WNK1
分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase WNK1
著者JIOU, J, CHLEBOWICZ, J, AKELLA, R, GOLDSMITH, E.J.
登録日2017-06-20
公開日2018-06-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献STRUCTURE OF PHOSPHORYLATED WNK1
To Be Published
6OL2
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Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening
分子名称: ACETATE ION, GLYCEROL, N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide, ...
著者Chlebowicz, J, Akella, R, Sekulski, K, Humphreys, J.M, Durbacz, M.Z, He, H, Rodan, A, Posner, B, Goldsmith, E.J.
登録日2019-04-15
公開日2020-04-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystallography of novel WNK1 and WNK3 inhibitors discovered from high throughput screening
To Be Published
3ENM
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The structure of the MAP2K MEK6 reveals an autoinhibitory dimer
分子名称: 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 6, GLYCEROL, ...
著者Min, X, Akella, R, He, H, Humphreys, J.M, Tsutakawa, S, Lee, S.-J, Tainer, J.A, Cobb, M.H, Goldsmith, E.J.
登録日2008-09-25
公開日2009-03-03
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The structure of the MAP2K MEK6 reveals an autoinhibitory dimer
Structure, 17, 2009
2NVA
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The X-ray crystal structure of the Paramecium bursaria Chlorella virus arginine decarboxylase bound to agmatine
分子名称: (4-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, arginine decarboxylase, A207R protein
著者Shah, R.H, Akella, R, Goldsmith, E, Phillips, M.A.
登録日2006-11-11
公開日2007-03-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity.
Biochemistry, 46, 2007
2NV9
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The X-ray Crystal Structure of the Paramecium bursaria Chlorella virus arginine decarboxylase
分子名称: A207R protein, arginine decarboxylase, PYRIDOXAL-5'-PHOSPHATE
著者Shah, R.H, Akella, R, Goldsmith, E, Phillips, M.A.
登録日2006-11-11
公開日2007-03-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity.
Biochemistry, 46, 2007
4Q2A
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WNK1: A chloride sensor via autophosphorylation
分子名称: BROMIDE ION, Serine/threonine-protein kinase WNK1
著者Piala, A, Moon, T, Akella, R, He, H, Cobb, M.H, Goldsmith, E.
登録日2014-04-07
公開日2014-05-28
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation.
Sci.Signal., 7, 2014
1LEW
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CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A
分子名称: Mitogen-activated protein kinase 14, Myocyte-specific enhancer factor 2A
著者Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J.
登録日2002-04-10
公開日2002-07-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.
Mol.Cell, 9, 2002
1LEZ
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BU of 1lez by Molmil
CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B
分子名称: MAP kinase kinase 3b, MITOGEN-ACTIVATED PROTEIN KINASE 14
著者Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J.
登録日2002-04-10
公開日2002-07-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.
Mol.Cell, 9, 2002

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件を2024-10-30に公開中

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