8TWP
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![BU of 8twp by Molmil](/molmil-images/mine/8twp) | Influenza A virus (A/Aichi/2/1968(H3N2) nucleoprotein mutant - 2-7 deleted, R416A | 分子名称: | Nucleoprotein | 著者 | Yoon, J, Zhang, Y.M, Grant, R.A, Shoulders, M.D. | 登録日 | 2023-08-21 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The immune-evasive proline-283 substitution in influenza nucleoprotein increases aggregation propensity without altering the native structure. Sci Adv, 10, 2024
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7KCC
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![BU of 7kcc by Molmil](/molmil-images/mine/7kcc) | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AG-270 | 分子名称: | 1,2-ETHANEDIOL, 3-(cyclohex-1-en-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-[(pyridin-2-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, CHLORIDE ION, ... | 著者 | Padyana, A, Jin, L. | 登録日 | 2020-10-05 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J.Med.Chem., 64, 2021
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8B08
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![BU of 8b08 by Molmil](/molmil-images/mine/8b08) | TRYPTOPHAN SYNTHASE - Cryo-trapping by the spitrobot crystal plunger after 30 sec | 分子名称: | CESIUM ION, CHLORIDE ION, SN-GLYCEROL-3-PHOSPHATE, ... | 著者 | Mehrabi, P, Sung, S, von Stetten, D, Prester, A, Hatton, C.E, Kleine-Dopke, S, Berkes, A, Gore, G, Leimkohl, J.P, Schikora, H, Kollewe, M, Rohde, H, Wilmanns, M, Tellkamp, F, Schulz, E.C. | 登録日 | 2022-09-07 | 公開日 | 2023-05-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Millisecond cryo-trapping by the spitrobot crystal plunger simplifies time-resolved crystallography. Nat Commun, 14, 2023
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8B06
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![BU of 8b06 by Molmil](/molmil-images/mine/8b06) | TRYPTOPHAN SYNTHASE - Cryo-trapping by the spitrobot crystal plunger after 25 sec | 分子名称: | CESIUM ION, CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Mehrabi, P, Sung, S, von Stetten, D, Prester, A, Hatton, C.E, Kleine-Dopke, S, Berkes, A, Gore, G, Leimkohl, J.P, Schikora, H, Kollewe, M, Rohde, H, Wilmanns, M, Tellkamp, F, Schulz, E.C. | 登録日 | 2022-09-07 | 公開日 | 2023-05-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Millisecond cryo-trapping by the spitrobot crystal plunger simplifies time-resolved crystallography. Nat Commun, 14, 2023
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7UJG
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![BU of 7ujg by Molmil](/molmil-images/mine/7ujg) | |
5KF2
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![BU of 5kf2 by Molmil](/molmil-images/mine/5kf2) | X-ray structure of a glucosamine N-Acetyltransferase from Clostridium acetobutylicum, apo form, pH 8 | 分子名称: | 1,2-ETHANEDIOL, ACETYL COENZYME *A, COENZYME A, ... | 著者 | Holden, H.M, Thoden, J.B, Dopkins, B.J, Tipton, P.A. | 登録日 | 2016-06-11 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Studies on a Glucosamine/Glucosaminide N-Acetyltransferase. Biochemistry, 55, 2016
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8E11
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![BU of 8e11 by Molmil](/molmil-images/mine/8e11) | |
7UQ0
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![BU of 7uq0 by Molmil](/molmil-images/mine/7uq0) | Putative periplasmic iron siderophore binding protein FecB (Rv3044) from Mycobacterium tuberculosis | 分子名称: | CITRIC ACID, GLYCEROL, PENTAETHYLENE GLYCOL, ... | 著者 | Chao, A, Cuthbert, B.J, Goulding, C.W. | 登録日 | 2022-04-18 | 公開日 | 2022-10-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake. Plos Pathog., 19, 2023
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8B05
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![BU of 8b05 by Molmil](/molmil-images/mine/8b05) | TRYPTOPHAN SYNTHASE - Cryo-trapping by the spitrobot crystal plunger after 20 sec | 分子名称: | CESIUM ION, CHLORIDE ION, INDOLE, ... | 著者 | Mehrabi, P, Sung, S, von Stetten, D, Prester, A, Hatton, C.E, Kleine-Dopke, S, Berkes, A, Gore, G, Leimkohl, J.P, Schikora, H, Kollewe, M, Rohde, H, Wilmanns, M, Tellkamp, F, Schulz, E.C. | 登録日 | 2022-09-07 | 公開日 | 2023-05-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Millisecond cryo-trapping by the spitrobot crystal plunger simplifies time-resolved crystallography. Nat Commun, 14, 2023
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7U9G
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![BU of 7u9g by Molmil](/molmil-images/mine/7u9g) | Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein, RVA122 Fab Heavy Chain, ... | 著者 | Callaway, H.M, Zyla, D, Larrous, F, Dias de Melo, G, Hastie, K.M, Avalos, R.D, Agarwal, A, Bouhry, H, Corti, D, Saphire, E.O. | 登録日 | 2022-03-10 | 公開日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Sci Adv, 8, 2022
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5XB2
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![BU of 5xb2 by Molmil](/molmil-images/mine/5xb2) | ADP-Mg-F-dTMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FLUORIDE ION, MAGNESIUM ION, ... | 著者 | Biswas, A, Jeyakanthan, J, Sekar, K. | 登録日 | 2017-03-15 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.161 Å) | 主引用文献 | Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate FEBS J., 284, 2017
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6S1A
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![BU of 6s1a by Molmil](/molmil-images/mine/6s1a) | Ligand binding domain of the P. putida receptor PcaY_PP | 分子名称: | Aromatic acid chemoreceptor, SULFATE ION | 著者 | Gavira, J.A, Matilla, M.A, Fernandez, M, Krell, T. | 登録日 | 2019-06-18 | 公開日 | 2020-10-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.112 Å) | 主引用文献 | The structural basis for signal promiscuity in a bacterial chemoreceptor. Febs J., 288, 2021
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7UF1
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![BU of 7uf1 by Molmil](/molmil-images/mine/7uf1) | RibB from Vibrio cholera bound with D-Ribose-5-phosphate (D-R5P) and manganese | 分子名称: | 3,4-dihydroxy-2-butanone 4-phosphate synthase, MANGANESE (II) ION, RIBOSE-5-PHOSPHATE | 著者 | Kenjic, N, Meneely, K.M, Lamb, A.L. | 登録日 | 2022-03-22 | 公開日 | 2022-07-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis. J.Am.Chem.Soc., 144, 2022
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8OG3
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![BU of 8og3 by Molmil](/molmil-images/mine/8og3) | E. coli NfsB triple mutant T41L/N71S/F124T bound to citrate | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, FLAVIN MONONUCLEOTIDE, ... | 著者 | Day, M.A, White, S.A, Hyde, E.I, Searle, P.F. | 登録日 | 2023-03-17 | 公開日 | 2023-04-19 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954. Int J Mol Sci, 24, 2023
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8OEG
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![BU of 8oeg by Molmil](/molmil-images/mine/8oeg) | PDE4B bound to MAPI compound 92a | 分子名称: | MAGNESIUM ION, ZINC ION, [(1~{S})-2-[3,5-bis(chloranyl)-1-oxidanyl-pyridin-4-yl]-1-(3,4-dimethoxyphenyl)ethyl] 5-[[[(1~{R})-2-[[(3~{R})-1-azabicyclo[2.2.2]octan-3-yl]oxy]-2-oxidanylidene-1-phenyl-ethyl]amino]methyl]thiophene-2-carboxylate, ... | 著者 | Rizzi, A, Armani, E. | 登録日 | 2023-03-10 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Optimization of M 3 Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD. J.Med.Chem., 66, 2023
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8SI6
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![BU of 8si6 by Molmil](/molmil-images/mine/8si6) | Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in closed state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-8aH-4,8-methanobis[1]benzofuro[3,2-e:2',3'-g]isoquinoline-1,8a-diol, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-04-14 | 公開日 | 2023-05-17 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | Structural mechanisms of TRPM7 activation and inhibition. Nat Commun, 14, 2023
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5KI5
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![BU of 5ki5 by Molmil](/molmil-images/mine/5ki5) | Structural impact of single ribonucleotides in DNA | 分子名称: | DNA (5'-D(*CP*AP*GP*GP*CP*CP*TP*AP*A)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*CP*CP*TP*G)-3') | 著者 | Evich, M, Spring-Connell, A.M, Storici, F, Germann, M.W. | 登録日 | 2016-06-16 | 公開日 | 2016-08-24 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Impact of Single Ribonucleotide Residues in DNA. Chembiochem, 17, 2016
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5X4Y
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![BU of 5x4y by Molmil](/molmil-images/mine/5x4y) | Mutant human thymidylate synthase M190K crystallized in a sulfate-containing condition | 分子名称: | SULFATE ION, Thymidylate synthase | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | 登録日 | 2017-02-14 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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6S45
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![BU of 6s45 by Molmil](/molmil-images/mine/6s45) | Room temperature structure of the dark state of the LOV2 domain of phototropin-2 from Arabidopsis thaliana determined with a serial crystallography approach | 分子名称: | FLAVIN MONONUCLEOTIDE, Phototropin-2 | 著者 | Aumonier, S, Santoni, G, Gotthard, G, von Stetten, D, Leonard, G, Royant, A. | 登録日 | 2019-06-26 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Millisecond time-resolved serial oscillation crystallography of a blue-light photoreceptor at a synchrotron. Iucrj, 7, 2020
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7UZQ
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![BU of 7uzq by Molmil](/molmil-images/mine/7uzq) | Local refinement of RhAG-RhCE-ANK1(AR1-5), from consensus refinement of all classes | 分子名称: | Ammonium transporter Rh type A, Ankyrin-1, Blood group Rh(CE) polypeptide, ... | 著者 | Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B. | 登録日 | 2022-05-09 | 公開日 | 2022-07-20 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.17 Å) | 主引用文献 | Architecture of the human erythrocyte ankyrin-1 complex. Nat.Struct.Mol.Biol., 29, 2022
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5KIE
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![BU of 5kie by Molmil](/molmil-images/mine/5kie) | Structural impact of single ribonucleotides in DNA | 分子名称: | DNA (5'-D(*GP*AP*GP*CP*TP*CP*CP*AP*T)-3'), DNA/RNA (5'-D(*AP*TP*GP*GP*A)-R(P*G)-D(P*CP*TP*C)-3') | 著者 | Evich, M, Spring-Connell, A.M, Storici, F, Germann, M.W. | 登録日 | 2016-06-16 | 公開日 | 2016-08-24 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Impact of Single Ribonucleotide Residues in DNA. Chembiochem, 17, 2016
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8AW9
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![BU of 8aw9 by Molmil](/molmil-images/mine/8aw9) | Xylose Isomerase in 75% relative humidity environment | 分子名称: | GLYCEROL, MAGNESIUM ION, MANGANESE (II) ION, ... | 著者 | Mehrabi, P, Sung, S, von Stetten, D, Prester, A, Hatton, C.E, Kleine-Doepke, S, Berkes, A, Gore, G, Leimkohl, J.P, Schikora, H, Kollewe, M, Rohde, H, Wilmanns, M, Tellkamp, F, Schulz, E.C. | 登録日 | 2022-08-29 | 公開日 | 2023-05-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Millisecond cryo-trapping by the spitrobot crystal plunger simplifies time-resolved crystallography. Nat Commun, 14, 2023
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5KDF
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![BU of 5kdf by Molmil](/molmil-images/mine/5kdf) | Inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with inhibitor 6 and inorganic pyrophosphate | 分子名称: | CALCIUM ION, Inorganic pyrophosphatase, PYROPHOSPHATE 2-, ... | 著者 | Pang, A.H, Garzan, A, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2016-06-08 | 公開日 | 2016-09-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis. ACS Chem. Biol., 11, 2016
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8AW8
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![BU of 8aw8 by Molmil](/molmil-images/mine/8aw8) | Xylose Isomerase in 70% relative humidity environment | 分子名称: | GLYCEROL, MAGNESIUM ION, MANGANESE (II) ION, ... | 著者 | Mehrabi, P, Sung, S, von Stetten, D, Prester, A, Hatton, C.E, Kleine-Doepke, S, Berkes, A, Gore, G, Leimkohl, J.P, Schikora, H, Kollewe, M, Rohde, H, Wilmanns, M, Tellkamp, F, Schulz, E.C. | 登録日 | 2022-08-29 | 公開日 | 2023-05-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Millisecond cryo-trapping by the spitrobot crystal plunger simplifies time-resolved crystallography. Nat Commun, 14, 2023
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8SI5
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![BU of 8si5 by Molmil](/molmil-images/mine/8si5) | Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in open state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-8aH-4,8-methanobis[1]benzofuro[3,2-e:2',3'-g]isoquinoline-1,8a-diol, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-04-14 | 公開日 | 2023-05-17 | 実験手法 | ELECTRON MICROSCOPY (2.17 Å) | 主引用文献 | Structural mechanisms of TRPM7 activation and inhibition. Nat Commun, 14, 2023
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