1V06
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8B8H
| Structure of DCS-resistant variant D322N of alanine racemase from M. tuberculosis in complex with DCS | 分子名称: | (~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylidene-[(4~{R})-3-oxidanylidene-1,2-oxazolidin-4-yl]azanium, 1,2-ETHANEDIOL, Alanine racemase, ... | 著者 | de Chiara, C, Prosser, G, Ogrodowicz, R.W, de Carvalho, L.P.S. | 登録日 | 2022-10-04 | 公開日 | 2023-04-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase from Mycobacterium tuberculosis . Acs Bio Med Chem Au, 3, 2023
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8AHW
| Structure of DCS-resistant variant D322N of alanine racemase from Mycobacterium tuberculosis | 分子名称: | 1,2-ETHANEDIOL, Alanine racemase, GLYCEROL | 著者 | de Chiara, C, Prosser, G, Ogrodowicz, R.W, de Carvalho, L.P.S. | 登録日 | 2022-07-22 | 公開日 | 2023-04-05 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase from Mycobacterium tuberculosis . Acs Bio Med Chem Au, 3, 2023
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2M41
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6SCZ
| Mycobacterium tuberculosis alanine racemase inhibited by DCS | 分子名称: | (~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylidene-[(4~{R})-3-oxidanylidene-1,2-oxazolidin-4-yl]azanium, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | de Chiara, C, Purkiss, A, Prosser, G, Homsak, M, de Carvalho, L.P.S. | 登録日 | 2019-07-26 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition. Nat.Chem.Biol., 16, 2020
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2JQD
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4AQP
| The structure of the AXH domain of ataxin-1. | 分子名称: | ATAXIN-1, DI(HYDROXYETHYL)ETHER, SODIUM ION | 著者 | Rees, M, Chen, Y.W, de Chiara, C, Pastore, A. | 登録日 | 2012-04-19 | 公開日 | 2013-03-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.452 Å) | 主引用文献 | Self-Assembly and Conformational Heterogeneity of the Axh Domain of Ataxin-1: An Unusual Example of a Chameleon Fold Biophys.J., 104, 2013
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4APT
| The structure of the AXH domain of ataxin-1. | 分子名称: | ATAXIN-1, SODIUM ION | 著者 | Rees, M, Chen, Y.W, de Chiara, C, Pastore, A. | 登録日 | 2012-04-05 | 公開日 | 2013-03-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Self-Assembly and Conformational Heterogeneity of the Axh Domain of Ataxin-1: An Unusual Example of a Chameleon Fold Biophys.J., 104, 2013
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1QUW
| SOLUTION STRUCTURE OF THE THIOREDOXIN FROM BACILLUS ACIDOCALDARIUS | 分子名称: | THIOREDOXIN | 著者 | Nicastro, G, de Chiara, C, Pedone, E, Tato, M, Rossi, M. | 登録日 | 1999-07-02 | 公開日 | 2000-01-26 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR solution structure of a novel thioredoxin from Bacillus acidocaldarius possible determinants of protein stability. Eur.J.Biochem., 267, 2000
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1H5O
| Solution structure of Crotamine, a neurotoxin from Crotalus durissus terrificus | 分子名称: | MYOTOXIN | 著者 | Nicastro, G, Franzoni, L, De Chiara, C, Mancin, C.A, Giglio, J.R, Spisni, A. | 登録日 | 2001-05-23 | 公開日 | 2003-05-09 | 最終更新日 | 2013-07-24 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of Crotamine, a Na+ Channel Affecting Toxin from Crotalus Durissus Terrificus Venom Eur.J.Biochem., 270, 2003
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2LFU
| The structure of a N. meningitides protein targeted for vaccine development | 分子名称: | Gna2132 | 著者 | Esposito, V, Musi, V, De Chiara, C, Kelly, G, Veggi, D, Pizza, M, Pastore, A. | 登録日 | 2011-07-15 | 公開日 | 2011-10-19 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the C-terminal Domain of Neisseria Heparin Binding Antigen (NHBA), One of the Main Antigens of a Novel Vaccine against Neisseria meningitidis. J.Biol.Chem., 286, 2011
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6GE9
| Structure of Mycobacterium tuberculosis GlmU bound to Glc-1P and Ac-CoA | 分子名称: | 1,2-ETHANEDIOL, 1-O-phosphono-alpha-D-glucopyranose, ACETYL COENZYME *A, ... | 著者 | Craggs, P.D, Mouilleron, S, Rejzek, M, de Chiara, C, Young, R.J, Field, R.A, Argyrou, A, de Carvalho, L.P.S. | 登録日 | 2018-04-25 | 公開日 | 2018-05-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | The Mechanism of Acetyl Transfer Catalyzed by Mycobacterium tuberculosis GlmU. Biochemistry, 57, 2018
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5LSD
| recombinant mouse Nerve Growth Factor | 分子名称: | Beta-nerve growth factor | 著者 | Paoletti, F, de Chiara, C, Kelly, G, Lamba, D, Cattaneo, A, Pastore, A. | 登録日 | 2016-08-25 | 公開日 | 2017-07-05 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor. Front Mol Biosci, 3, 2016
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2KTM
| Solution NMR structure of H2H3 domain of ovine prion protein (residues 167-234) | 分子名称: | Major prion protein | 著者 | Pastore, A, Adrover, M, Pauwels, K, de Chiara, C, Prigent, S, Rezeai, H. | 登録日 | 2010-02-04 | 公開日 | 2010-04-07 | 最終更新日 | 2021-11-10 | 実験手法 | SOLUTION NMR | 主引用文献 | Prion fibrillization is mediated by a native structural element that comprises helices H2 and H3. J.Biol.Chem., 285, 2010
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5LHU
| ATP Phosphoribosyltransferase from Mycobacterium tuberculosis in complex with the allosteric inhibitor L-Histidine | 分子名称: | ATP phosphoribosyltransferase, GLYCEROL, HISTIDINE, ... | 著者 | de Chiara, C, Pisco, J.P, de Carvalho, L.P, Smerdon, S.J, Walker, P.A, Ogrodowicz, R. | 登録日 | 2016-07-12 | 公開日 | 2017-06-21 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Uncoupling conformational states from activity in an allosteric enzyme. Nat Commun, 8, 2017
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5LHT
| ATP Phosphoribosyltransferase from Mycobacterium tuberculosis in complex with the allosteric activator 3-(2-Thienyl)-L-alanine | 分子名称: | ATP phosphoribosyltransferase, BETA(2-THIENYL)ALANINE, GLYCEROL, ... | 著者 | de Chiara, C, Pisco, J.P, de Carvalho, L.P, Smerdon, S.J, Walker, P.A, Ogrodowicz, R. | 登録日 | 2016-07-12 | 公開日 | 2017-07-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.0601 Å) | 主引用文献 | Uncoupling conformational states from activity in an allosteric enzyme. Nat Commun, 8, 2017
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1OA8
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4C5A
| The X-ray crystal structures of D-alanyl-D-alanine ligase in complex ADP and D-cycloserine phosphate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, D-ALANINE--D-ALANINE LIGASE, GLYCEROL, ... | 著者 | Batson, S, Majce, V, Lloyd, A.J, Rea, D, Fishwick, C.W.G, Simmons, K.J, Fulop, V, Roper, D.I. | 登録日 | 2013-09-10 | 公開日 | 2015-01-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nat Commun, 8, 2017
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4C5B
| The X-ray crystal structure of D-alanyl-D-alanine ligase in complex with ATP and D-ala-D-ala | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CARBONATE ION, D-ALANINE, ... | 著者 | Batson, S, Majce, V, Lloyd, A.J, Rea, D, Fishwick, C.W.G, Simmons, K.J, Fulop, V, Roper, D.I. | 登録日 | 2013-09-10 | 公開日 | 2015-01-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nat Commun, 8, 2017
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4C5C
| The X-ray crystal structure of D-alanyl-D-alanine ligase in complex with ADP and D-ala-D-ala | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, D-ALANINE, D-ALANINE--D-ALANINE LIGASE, ... | 著者 | Batson, S, Majce, V, Lloyd, A.J, Rea, D, Fishwick, C.W.G, Simmons, K.J, Fulop, V, Roper, D.I. | 登録日 | 2013-09-10 | 公開日 | 2015-01-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nat Commun, 8, 2017
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