6JUZ
 
 | | Crystal Structure of N-terminal domain of ArgZ(N71S) covalently bond to a reaction intermediate | | 分子名称: | 1,2-ETHANEDIOL, ARGININE, Sll1336 protein | | 著者 | Zhuang, N, Li, L, Wu, X, Zhuang, Y. | | 登録日 | 2019-04-15 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | | 主引用文献 | Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.
J.Biol.Chem., 295, 2020
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5JK5
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5JK6
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5JK8
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4HAC
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4HU0
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4HTY
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6JV0
 | | Crystal Structure of N-terminal domain of ArgZ, bound to Product, an arginine dihydrolase from the Ornithine-Ammonia Cycle in Cyanobacteria | | 分子名称: | 1,2-ETHANEDIOL, L-ornithine, Sll1336 protein | | 著者 | Zhuang, N, Li, L, Wu, X, Zhang, Y. | | 登録日 | 2019-04-15 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | | 主引用文献 | Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.
J.Biol.Chem., 295, 2020
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6JUY
 | | Crystal Structure of ArgZ, apo structure, an Arginine Dihydrolase from the Ornithine-Ammonia Cycle in Cyanobacteria | | 分子名称: | Sll1336 protein | | 著者 | Zhuang, N, Li, L, Wu, X, Zhang, Y. | | 登録日 | 2019-04-15 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | | 主引用文献 | Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.
J.Biol.Chem., 295, 2020
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6JV1
 | | Crystal Structure of N-terminal domain of ArgZ, C264S mutant, bound to Substrate, an arginine dihydrolase from the Ornithine-Ammonia Cycle in Cyanobacteria | | 分子名称: | ARGININE, Sll1336 protein | | 著者 | Zhuang, N, Li, L, Wu, X, Zhang, Y. | | 登録日 | 2019-04-15 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.
J.Biol.Chem., 295, 2020
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8UPS
 | | Structure of SARS-Cov2 3CLPro in complex with Compound 5 | | 分子名称: | (1R,2S,5S)-N-{(2S,3R)-4-amino-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5, PHOSPHATE ION | | 著者 | Wu, Y, Qiang, D, Zhuang, N, Krishnamurthy, H, Klein, D.J. | | 登録日 | 2023-10-23 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J.Med.Chem., 67, 2024
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8UPW
 | | Structure of SARS-Cov2 3CLPro in complex with Compound 34 | | 分子名称: | 3C-like proteinase nsp5, methyl {(2S)-1-[(1S,3aR,6aS)-1-{[(2R,3S,6S)-6-fluoro-2-hydroxy-1-(methylamino)-1-oxoheptan-3-yl]carbamoyl}hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-3,3-dimethyl-1-oxobutan-2-yl}carbamate | | 著者 | Krishnamurthy, H, Zhuang, N, Qiang, D, Wu, Y, Klein, D.J. | | 登録日 | 2023-10-23 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J.Med.Chem., 67, 2024
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8UPV
 | | Structure of SARS-Cov2 3CLPro in complex with Compound 33 | | 分子名称: | 3C-like proteinase nsp5, methyl {(2S)-1-[(1S,3aR,6aS)-1-{[(2R,3S,6R)-6-fluoro-2-hydroxy-1-(methylamino)-1-oxoheptan-3-yl]carbamoyl}hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-3,3-dimethyl-1-oxobutan-2-yl}carbamate | | 著者 | Krishnamurthy, H, Zhuang, N, Qiang, D, Wu, Y, Klein, D.J. | | 登録日 | 2023-10-23 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J.Med.Chem., 67, 2024
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8UTE
 | | Structure of SARS-Cov2 3CLPro in complex with Compound 27 | | 分子名称: | 1,2-ETHANEDIOL, 3C-like proteinase nsp5, methyl {(2S)-1-[(1S,3aR,6aS)-1-{[(2R,3S)-6,6-difluoro-2-hydroxy-1-(methylamino)-1-oxoheptan-3-yl]carbamoyl}hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-3,3-dimethyl-1-oxobutan-2-yl}carbamate | | 著者 | Krishnamurthy, H, Zhuang, N, Qiang, D, Wu, Y, Klein, D.J. | | 登録日 | 2023-10-31 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J.Med.Chem., 67, 2024
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3ORF
 | | Crystal Structure of Dihydropteridine Reductase from Dictyostelium discoideum | | 分子名称: | Dihydropteridine reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Chen, C, Zhuang, N.N, Seo, K.H, Park, Y.S, Lee, K.H. | | 登録日 | 2010-09-07 | | 公開日 | 2011-07-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Structural insights into the dual substrate specificities of mammalian and Dictyostelium dihydropteridine reductases toward two stereoisomers of quinonoid dihydrobiopterin
Febs Lett., 585, 2011
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3QNA
 | | Crystal structure of a 6-pyruvoyltetrahydropterin synthase homologue from Esherichia coli complexed sepiapterin | | 分子名称: | 6-carboxy-5,6,7,8-tetrahydropterin synthase, BIOPTERIN, ZINC ION | | 著者 | Seo, K.H, Zhuang, N.N, Lee, K.H. | | 登録日 | 2011-02-08 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis of a novel activity of bacterial 6-pyruvoyltetrahydropterin synthase homologues distinct from mammalian 6-pyruvoyltetrahydropterin synthase activity.
Acta Crystallogr.,Sect.D, 70, 2014
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3QN9
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3QN0
 | | Structure of 6-pyruvoyltetrahydropterin synthase | | 分子名称: | 6-carboxy-5,6,7,8-tetrahydropterin synthase, ZINC ION | | 著者 | Seo, K.H, Zhuang, N.N, Lee, K.H. | | 登録日 | 2011-02-07 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structural basis of a novel activity of bacterial 6-pyruvoyltetrahydropterin synthase homologues distinct from mammalian 6-pyruvoyltetrahydropterin synthase activity.
Acta Crystallogr.,Sect.D, 70, 2014
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5YIU
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5YIW
 | | Caulobacter crescentus GcrA DNA-binding domain (DBD) in complex with methylated dsDNA (crystal form 2) | | 分子名称: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*CP*TP*GP*(6MA)P*TP*TP*CP*GP*C)-3'), ... | | 著者 | Wu, X, Zhang, Y. | | 登録日 | 2017-10-06 | | 公開日 | 2018-03-21 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.551 Å) | | 主引用文献 | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
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5YIV
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5YIX
 | | Caulobacter crescentus GcrA sigma-interacting domain (SID) in complex with domain 2 of sigma 70 | | 分子名称: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, RNA polymerase sigma factor RpoD, ... | | 著者 | Wu, X, Zhang, Y. | | 登録日 | 2017-10-06 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | | 主引用文献 | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
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5Z7I
 | | Caulobacter crescentus GcrA DNA-binding domain(DBD)in complex with unmethylated dsDNA | | 分子名称: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*CP*TP*GP*AP*TP*TP*CP*GP*C*)-3'), ... | | 著者 | Wu, X, Zhang, Y. | | 登録日 | 2018-01-29 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | | 主引用文献 | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
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5ZX3
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5ZX2
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