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2WPO
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HCMV protease inhibitor complex
分子名称: (2S)-2-(3,3-dimethylbutanoylamino)-N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[(4-iodophenyl)methylamino]-4-oxo-butan-2-yl]amino]- 1,4-dioxo-4-pyrrol-1-yl-butan-2-yl]-3,3-dimethyl-butanamide, HUMAN CYTOMEGALOVIRUS PROTEASE
著者Tong, L, Qian, C, Massariol, M.-J, Deziel, R, Yoakim, C, Lagace, L.
登録日1998-08-04
公開日1999-08-04
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease.
Nat.Struct.Biol., 5, 1998
1BIM
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BU of 1bim by Molmil
CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS
分子名称: (2S)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-{(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-2-[(3R)-1,5,5-trimethyl-2-oxopyrrolidin-3-yl]ethyl}-N~4~-[2-(dimethylamino)-2-oxoethyl]-N~4~-[(1S)-1-phenylethyl]butanediamide, Renin
著者Tong, L.
登録日1995-09-27
公開日1996-01-29
最終更新日2022-03-09
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors.
J.Biol.Chem., 270, 1995
1BHF
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P56LCK SH2 DOMAIN INHIBITOR COMPLEX
分子名称: INHIBITOR ACE-IPA-GLU-GLU-ILE, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK
著者Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S.
登録日1998-06-08
公開日1998-10-21
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
1BIL
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BU of 1bil by Molmil
CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS
分子名称: (2S)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-[(1S,2R,3R)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-N~4~-[2-(d imethylamino)-2-oxoethyl]-N~4~-[(1S)-1-phenylethyl]butanediamide, Renin
著者Tong, L.
登録日1995-09-27
公開日1996-01-29
最終更新日2022-03-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors.
J.Biol.Chem., 270, 1995
1BHH
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BU of 1bhh by Molmil
FREE P56LCK SH2 DOMAIN
分子名称: P56 LCK TYROSINE KINASE SH2 DOMAIN, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK
著者Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S.
登録日1998-06-08
公開日1998-10-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
1IDA
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BU of 1ida by Molmil
CRYSTAL STRUCTURES OF HIV-2 PROTEASE IN COMPLEX WITH INHIBITORS CONTAINING THE HYDROXYETHYLAMINE DIPEPTIDE ISOSTERE
分子名称: N-[(1R)-1-{[(1S,2S)-1-benzyl-3-{(2R,4S)-2-(tert-butylcarbamoyl)-4-[(pyridin-3-ylmethyl)sulfanyl]piperidin-1-yl}-2-hydroxypropyl]carbamoyl}-2-methylpropyl]quinoline-2-carboxamide, Protease
著者Tong, L, Anderson, P.C.
登録日1994-10-19
公開日1995-01-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere.
Structure, 3, 1995
1IDB
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Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere
分子名称: (2R,4S)-N-tert-butyl-1-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutyl]-4-(pyridin-4-ylsulfonyl)piperidine-2-carboxamide, Protease
著者Tong, L, Anderson, P.C.
登録日1994-10-19
公開日1995-01-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere.
Structure, 3, 1995
1HRN
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HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS
分子名称: (2R,4S,5S)-N-[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]-2-(cyclopropylmethyl)-4,5-dihydroxy-6-phenylhexanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, RENIN
著者Tong, L, Anderson, P.C.
登録日1995-03-31
公開日1995-06-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors.
J.Mol.Biol., 250, 1995
1IAN
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BU of 1ian by Molmil
HUMAN P38 MAP KINASE INHIBITOR COMPLEX
分子名称: 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE, P38 MAP KINASE
著者Tong, L.
登録日1997-03-07
公開日1998-05-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket.
Nat.Struct.Biol., 4, 1997
1LKK
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HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE (PYEEI PEPTIDE)
分子名称: ACETYL GROUP, HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE
著者Tong, L.
登録日1995-11-10
公開日1996-03-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution.
J.Mol.Biol., 256, 1996
1LKL
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HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE)
分子名称: HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY
著者Tong, L.
登録日1995-11-10
公開日1996-03-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution.
J.Mol.Biol., 256, 1996
1WPO
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HYDROLYTIC ENZYME HUMAN CYTOMEGALOVIRUS PROTEASE
分子名称: HUMAN CYTOMEGALOVIRUS PROTEASE, SULFATE ION
著者Tong, L.
登録日1996-07-23
公開日1997-10-15
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease.
Nature, 383, 1996
2SNV
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BU of 2snv by Molmil
THE REFINED STRUCTURE OF SINDBIS VIRUS CORE PROTEIN IN COMPARISON WITH OTHER CHYMOTRYPSIN-LIKE SERINE PROTEINASE STRUCTURES
分子名称: SINDBIS VIRUS COAT PROTEIN
著者Tong, L, Rossmann, M.G.
登録日1992-07-17
公開日1993-10-31
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures.
J.Mol.Biol., 230, 1993
2MIP
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BU of 2mip by Molmil
CRYSTAL STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) TYPE 2 PROTEASE IN COMPLEX WITH A REDUCED AMIDE INHIBITOR AND COMPARISON WITH HIV-1 PROTEASE STRUCTURES
分子名称: HIV-2 PROTEASE, INHIBITOR BI-LA-398
著者Tong, L, Pav, S, Pargellis, C, Do, F, Lamarre, D, Anderson, P.C.
登録日1993-06-03
公開日1993-10-31
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of human immunodeficiency virus (HIV) type 2 protease in complex with a reduced amide inhibitor and comparison with HIV-1 protease structures.
Proc.Natl.Acad.Sci.USA, 90, 1993
6O3P
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BU of 6o3p by Molmil
Crystal structure of the catalytic domain of mouse Nudt12 in complex with AMP and 3 Mg2+ ions
分子名称: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, Peroxisomal NADH pyrophosphatase NUDT12, ...
著者Tong, L, Wu, Y.
登録日2019-02-27
公開日2019-05-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and mechanistic basis of mammalian Nudt12 RNA deNADding.
Nat.Chem.Biol., 15, 2019
6DKN
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA DECAPPING NUCLEASE DXO1
分子名称: Decapping nuclease DXO homolog, chloroplastic
著者Tong, L, Wang, V.Y.F.
登録日2018-05-30
公開日2019-02-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity.
Nucleic Acids Res., 47, 2019
1JLD
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Potent hiv protease inhibitors containing a novel (hydroxyethyl)amide isostere
分子名称: (2S)-2-tert-butyl-N~4~-(1-ethylpropyl)-N~1~-[(2R,3S)-2-hydroxy-4-phenyl-3-{[N-(quinolin-2-ylcarbonyl)-L-threonyl]amino}butyl]butanediamide, Pol polyprotein
著者Tong, L.
登録日1997-05-31
公開日1997-12-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.
J.Med.Chem., 40, 1997
3PGQ
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Crystal Structure of the Carboxyltransferase Domain of S. cerevisiae Acetyl CoA Carboxylase in Complex with Pinoxaden
分子名称: 8-(2-ethenyl-6-ethyl-4-methylphenyl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione, Acetyl-CoA carboxylase
著者Tong, L, Yu, L.P.C, Kim, Y.S.
登録日2010-11-02
公開日2010-12-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HBL
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Crystal Structure of S. aureus Pyruvate Carboxylase T908A Mutant
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
著者Tong, L, Yu, L.P.C.
登録日2009-05-04
公開日2009-06-30
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3HB9
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Crystal Structure of S. aureus Pyruvate Carboxylase A610T Mutant
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
著者Tong, L, Yu, L.P.C.
登録日2009-05-04
公開日2009-06-30
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3HO8
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Crystal Structure of S. aureus Pyruvate Carboxylase in complex with Coenzyme A
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, MANGANESE (II) ION, ...
著者Tong, L, Yu, L.P.C.
登録日2009-06-01
公開日2009-06-30
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3O2T
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Crystal structure of the N-terminal domain of human Symplekin
分子名称: 1,2-ETHANEDIOL, Symplekin
著者Tong, L, Xiang, K, Xiang, S.
登録日2010-07-22
公開日2010-10-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3O2Q
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Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex
分子名称: PHOSPHATE ION, RNA polymerase II CTD Serine-5 phosphopeptide, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, ...
著者Tong, L, Xiang, K.
登録日2010-07-22
公開日2010-10-06
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3ODS
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Crystal structure of the K185A mutant of the N-terminal domain of human Symplekin
分子名称: 1,2-ETHANEDIOL, Symplekin
著者Tong, L, Xiang, K.
登録日2010-08-11
公開日2010-10-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3O2S
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Crystal structure of the human symplekin-Ssu72 complex
分子名称: PHOSPHATE ION, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, Symplekin
著者Tong, L, Xiang, K.
登録日2010-07-22
公開日2010-10-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010

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