7FEM
 
 | | SARS-CoV-2 B.1.1.7 S-ACE2 complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | | Authors: | Wen, Z.L, Zhu, Y, Sun, F. | | Deposit date: | 2021-07-21 | | Release date: | 2021-12-15 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structure-based evidence for the enhanced transmissibility of the dominant SARS-CoV-2 B.1.1.7 variant (Alpha).
Cell Discov, 7, 2021
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7VDC
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7VD8
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7VD9
 | | 2.29 A structure of the human catalase | | Descriptor: | Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Fan, H.C, Zhang, Y, Sun, F. | | Deposit date: | 2021-09-06 | | Release date: | 2021-12-29 | | Method: | ELECTRON MICROSCOPY (2.29 Å) | | Cite: | A cryo-electron microscopy support film formed by 2D crystals of hydrophobin HFBI.
Nat Commun, 12, 2021
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7VDF
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7VDA
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7VDE
 | | 3.6 A structure of the human hemoglobin | | Descriptor: | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Fan, H.C, Zhang, Y, Sun, F. | | Deposit date: | 2021-09-06 | | Release date: | 2021-12-29 | | Last modified: | 2022-01-19 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | A cryo-electron microscopy support film formed by 2D crystals of hydrophobin HFBI.
Nat Commun, 12, 2021
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7CWK
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7D6D
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7D6E
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7E9T
 | | Nanometer resolution in situ structure of SARS-CoV-2 post-fusion spike | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2, ... | | Authors: | Zhu, Y, Tai, L, Zhu, G, Yin, G, Sun, F. | | Deposit date: | 2021-03-05 | | Release date: | 2021-11-17 | | Last modified: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (10.9 Å) | | Cite: | Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7EPC
 | | Cryo-EM structure of inactive mGlu7 homodimer | | Descriptor: | Isoform 3 of Metabotropic glutamate receptor 7 | | Authors: | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | | Deposit date: | 2021-04-26 | | Release date: | 2021-06-23 | | Last modified: | 2021-07-07 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures of human mGlu2 and mGlu7 homo- and heterodimers.
Nature, 594, 2021
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7EPA
 | | Cryo-EM structure of inactive mGlu2 homodimer | | Descriptor: | Metabotropic glutamate receptor 2 | | Authors: | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | | Deposit date: | 2021-04-26 | | Release date: | 2021-06-23 | | Last modified: | 2021-07-07 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of human mGlu2 and mGlu7 homo- and heterodimers.
Nature, 594, 2021
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7EPB
 | | Cryo-EM structure of LY354740-bound mGlu2 homodimer | | Descriptor: | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, Anti-RON nanobody, Metabotropic glutamate receptor 2 | | Authors: | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | | Deposit date: | 2021-04-26 | | Release date: | 2021-06-23 | | Last modified: | 2021-07-07 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structures of human mGlu2 and mGlu7 homo- and heterodimers.
Nature, 594, 2021
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7EPD
 | | Cryo-EM structure of inactive mGlu2-7 heterodimer | | Descriptor: | Isoform 3 of Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 2,Peptidylprolyl isomerase | | Authors: | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | | Deposit date: | 2021-04-26 | | Release date: | 2021-06-23 | | Last modified: | 2021-07-07 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures of human mGlu2 and mGlu7 homo- and heterodimers.
Nature, 594, 2021
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7F01
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7FB1
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7FB3
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7FB0
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7FB4
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1J4I
 | | crystal structure analysis of the FKBP12 complexed with 000308 small molecule | | Descriptor: | 4-METHYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PENTANOIC ACID, FKBP12 | | Authors: | Li, P, Ding, Y, Wang, L, Wu, B, Shu, C, Li, S, Shen, B, Rao, Z. | | Deposit date: | 2001-09-30 | | Release date: | 2003-06-03 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Design and structure-based study of new potential FKBP12 inhibitors.
Biophys.J., 85, 2003
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1J4H
 | | crystal structure analysis of the FKBP12 complexed with 000107 small molecule | | Descriptor: | 3-PHENYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PROPIONIC ACID ETHYL ESTER, FKBP12 | | Authors: | Li, P, Ding, Y, Wang, L, Wu, B, Shu, C, Li, S, Shen, B, Rao, Z. | | Deposit date: | 2001-09-30 | | Release date: | 2003-06-03 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Design and structure-based study of new potential FKBP12 inhibitors.
Biophys.J., 85, 2003
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4YNE
 | | (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors | | Descriptor: | 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine, GLYCEROL, High affinity nerve growth factor receptor, ... | | Authors: | Kreusch, A, Rucker, P, Molteni, V, Loren, J. | | Deposit date: | 2015-03-09 | | Release date: | 2015-06-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.0229 Å) | | Cite: | (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.
Acs Med.Chem.Lett., 6, 2015
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4YMJ
 | | (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors | | Descriptor: | 4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile, CHLORIDE ION, GLYCEROL, ... | | Authors: | Kreusch, A, Rucker, P, Molteni, V, Loren, J. | | Deposit date: | 2015-03-06 | | Release date: | 2015-06-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.
Acs Med.Chem.Lett., 6, 2015
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4YPS
 | | (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors | | Descriptor: | 4-{6-[(3R)-3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl}benzonitrile, High affinity nerve growth factor receptor, SULFATE ION | | Authors: | Kreusch, A, Rucker, P, Molteni, V, Loren, J. | | Deposit date: | 2015-03-13 | | Release date: | 2015-06-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.1012 Å) | | Cite: | (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.
Acs Med.Chem.Lett., 6, 2015
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