1TQ9
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![BU of 1tq9 by Molmil](/molmil-images/mine/1tq9) | Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE | Descriptor: | 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE, Ribonuclease, seminal | Authors: | Sica, F, Di Fiore, A, Merlino, A, Mazzarella, L. | Deposit date: | 2004-06-17 | Release date: | 2004-09-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and Stability of the Non-covalent Swapped Dimer of Bovine Seminal Ribonuclease: AN ENZYME TAILORED TO EVADE RIBONUCLEASE PROTEIN INHIBITOR J.Biol.Chem., 279, 2004
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1N3Z
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![BU of 1n3z by Molmil](/molmil-images/mine/1n3z) | Crystal structure of the [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] monomeric derivative of the bovine seminal ribonuclease in the liganded state | Descriptor: | 3'-URIDINEMONOPHOSPHATE, ADENOSINE, Ribonuclease, ... | Authors: | Sica, F, Di Fiore, A, Zagari, A, Mazzarella, L. | Deposit date: | 2002-10-30 | Release date: | 2003-08-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative Proteins, 52, 2003
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1N1X
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![BU of 1n1x by Molmil](/molmil-images/mine/1n1x) | Crystal Structure Analysis of the monomeric [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] Bovine seminal ribonuclease | Descriptor: | Ribonuclease, seminal | Authors: | Sica, F, Di Fiore, A, Zagari, A, Mazzarella, L. | Deposit date: | 2002-10-21 | Release date: | 2003-08-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative Proteins, 52, 2003
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7BFL
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![BU of 7bfl by Molmil](/molmil-images/mine/7bfl) | X-ray structure of SS-RNase-2 des116-120 | Descriptor: | Angiogenin-1 | Authors: | Sica, F, Russo Krauss, I, Troisi, R. | Deposit date: | 2021-01-04 | Release date: | 2021-04-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | The structural features of an ancient ribonuclease from Salmo salar reveal an intriguing case of auto-inhibition. Int.J.Biol.Macromol., 182, 2021
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7BFK
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![BU of 7bfk by Molmil](/molmil-images/mine/7bfk) | X-ray structure of SS-RNase-2 | Descriptor: | Angiogenin-1 | Authors: | Sica, F, Russo Krauss, I, Troisi, R. | Deposit date: | 2021-01-04 | Release date: | 2021-04-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | The structural features of an ancient ribonuclease from Salmo salar reveal an intriguing case of auto-inhibition. Int.J.Biol.Macromol., 182, 2021
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2P1X
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![BU of 2p1x by Molmil](/molmil-images/mine/2p1x) | |
2EFF
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![BU of 2eff by Molmil](/molmil-images/mine/2eff) | |
4N4C
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![BU of 4n4c by Molmil](/molmil-images/mine/4n4c) | Crystal structure of the C-terminal swapped dimer of a Bovine seminal ribonuclease mutant | Descriptor: | PHOSPHATE ION, Seminal ribonuclease | Authors: | Pica, A, Russo Krauss, I, Merlino, A, Sica, F. | Deposit date: | 2013-10-08 | Release date: | 2013-11-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | The multiple forms of bovine seminal ribonuclease: Structure and stability of a C-terminal swapped dimer. Febs Lett., 587, 2013
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6TJM
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![BU of 6tjm by Molmil](/molmil-images/mine/6tjm) | Crystal structure of an Estrogen Receptor alpha 8-mer phosphopeptide in complex with 14-3-3sigma stabilized by Pyrrolidone1 | Descriptor: | 14-3-3 protein sigma, 5-[(2~{R})-2-(4-nitrophenyl)-4-oxidanyl-5-oxidanylidene-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]-2-oxidanyl-benzoic acid, C-terminal phosphopeptide of human estrogen receptor alpha, ... | Authors: | Andrei, S.A, Bosica, F, Ottmann, C, O'Mahony, G. | Deposit date: | 2019-11-26 | Release date: | 2020-04-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization. Chemistry, 26, 2020
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6TL3
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![BU of 6tl3 by Molmil](/molmil-images/mine/6tl3) | Crystal structure of an Estrogen Receptor alpha 8-mer phosphopeptide in complex with 14-3-3sigma stabilized by a Pyrrolidone1 derivative | Descriptor: | 14-3-3 protein sigma, 5-[(2~{S},3~{R})-3-[(~{R})-azanyl(phenyl)methyl]-2-(4-nitrophenyl)-4,5-bis(oxidanylidene)pyrrolidin-1-yl]-2-oxidanyl-benzoic acid, Estrogen receptor | Authors: | Andrei, S.A, Bosica, F, Ottmann, C, O'Mahony, G. | Deposit date: | 2019-11-30 | Release date: | 2020-04-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.455 Å) | Cite: | Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization. Chemistry, 26, 2020
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11BG
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![BU of 11bg by Molmil](/molmil-images/mine/11bg) | A POTENTIAL ALLOSTERIC SUBSITE GENERATED BY DOMAIN SWAPPING IN BOVINE SEMINAL RIBONUCLEASE | Descriptor: | PROTEIN (BOVINE SEMINAL RIBONUCLEASE), SULFATE ION, URIDYLYL-2'-5'-PHOSPHO-GUANOSINE | Authors: | Vitagliano, L, Adinolfi, S, Sica, F, Merlino, A, Zagari, A, Mazzarella, L. | Deposit date: | 1999-03-11 | Release date: | 1999-11-05 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease. J.Mol.Biol., 293, 1999
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3BCP
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![BU of 3bcp by Molmil](/molmil-images/mine/3bcp) | Crystal Structure of The Swapped non covalent form of P19A/L28Q/N67D BS-RNase | Descriptor: | Seminal ribonuclease | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | Deposit date: | 2007-11-13 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
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3BCM
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![BU of 3bcm by Molmil](/molmil-images/mine/3bcm) | Crystal Structure of The Unswapped Form of P19A/L28Q/N67D BS-RNase | Descriptor: | PHOSPHATE ION, Seminal ribonuclease | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | Deposit date: | 2007-11-13 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
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3BCO
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![BU of 3bco by Molmil](/molmil-images/mine/3bco) | Crystal Structure of The Swapped FOrm of P19A/L28Q/N67D BS-RNase | Descriptor: | Seminal ribonuclease | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | Deposit date: | 2007-11-13 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
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4YIP
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![BU of 4yip by Molmil](/molmil-images/mine/4yip) | X-ray structure of the iron/manganese cambialistic superoxide dismutase from Streptococcus mutans | Descriptor: | FE (III) ION, Superoxide dismutase [Mn/Fe] | Authors: | Russo Krauss, I, Merlino, A, Pica, A, Sica, F. | Deposit date: | 2015-03-02 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Fine tuning of metal-specific activity in the Mn-like group of cambialistic superoxide dismutases Rsc Adv, 5, 2015
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4YIO
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![BU of 4yio by Molmil](/molmil-images/mine/4yio) | X-ray structure of the iron/manganese cambialistic superoxide dismutase from Streptococcus thermophilus | Descriptor: | FE (III) ION, GLYCEROL, SULFATE ION, ... | Authors: | Russo Krauss, I, Merlino, A, Pica, A, Sica, F. | Deposit date: | 2015-03-02 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fine tuning of metal-specific activity in the Mn-like group of cambialistic superoxide dismutases Rsc Adv, 5, 2015
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3LJ9
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![BU of 3lj9 by Molmil](/molmil-images/mine/3lj9) | X-ray structure of the iron superoxide dismutase from pseudoalteromonas haloplanktis in complex with sodium azide | Descriptor: | AZIDE ION, FE (III) ION, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose, ... | Authors: | Merlino, A, Russo Krauss, I, Rossi, B, Conte, M, Vergara, A, Sica, F. | Deposit date: | 2010-01-26 | Release date: | 2010-09-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and flexibility in cold-adapted iron superoxide dismutases: the case of the enzyme isolated from Pseudoalteromonas haloplanktis. J.Struct.Biol., 172, 2010
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11BA
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![BU of 11ba by Molmil](/molmil-images/mine/11ba) | BINDING OF A SUBSTRATE ANALOGUE TO A DOMAIN SWAPPING PROTEIN IN THE COMPLEX OF BOVINE SEMINAL RIBONUCLEASE WITH URIDYLYL-2',5'-ADENOSINE | Descriptor: | PROTEIN (RIBONUCLEASE, SEMINAL), SULFATE ION, ... | Authors: | Vitagliano, L, Adinolfi, S, Riccio, A, Sica, F, Zagari, A, Mazzarella, L. | Deposit date: | 1999-03-17 | Release date: | 1999-03-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2',5')adenosine. Protein Sci., 7, 1998
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5EW1
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![BU of 5ew1 by Molmil](/molmil-images/mine/5ew1) | Human thrombin sandwiched between two DNA aptamers: HD22 and HD1-deltaT3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, HD1-deltaT3, ... | Authors: | Pica, A, Russo Krauss, I, Parente, V, Sica, F. | Deposit date: | 2015-11-20 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers. Nucleic Acids Res., 45, 2017
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4I7Y
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![BU of 4i7y by Molmil](/molmil-images/mine/4i7y) | Crystal Structure of Human Alpha Thrombin in Complex with a 27-mer Aptamer Bound to Exosite II | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, DNA (27-MER), ... | Authors: | Pica, A, Russo Krauss, I, Merlino, A, Mazzarella, L, Sica, F. | Deposit date: | 2012-12-01 | Release date: | 2013-10-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer. Acta Crystallogr.,Sect.D, 69, 2013
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5EW2
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![BU of 5ew2 by Molmil](/molmil-images/mine/5ew2) | Human thrombin sandwiched between two DNA aptamers: HD22 and HD1-deltaT12 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, HD1-deltaT12, ... | Authors: | Pica, A, Russo Krauss, I, Parente, V, Sica, F. | Deposit date: | 2015-11-20 | Release date: | 2016-11-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.59 Å) | Cite: | Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers. Nucleic Acids Res., 45, 2017
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3LJE
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![BU of 3lje by Molmil](/molmil-images/mine/3lje) | The X-ray structure of zebrafish RNase5 | Descriptor: | ACETATE ION, SULFATE ION, Zebrafish RNase5 | Authors: | Russo Krauss, I, Merlino, A, Coscia, F, Mazzarella, L, Sica, F. | Deposit date: | 2010-01-26 | Release date: | 2010-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish. Biochem.J., 433, 2010
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3LN8
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![BU of 3ln8 by Molmil](/molmil-images/mine/3ln8) | The X-ray structure of Zf-RNase-1 from a new crystal form at pH 7.3 | Descriptor: | HYDROLASE, SULFATE ION | Authors: | Russo Krauss, I, Merlino, A, Mazzarella, L, Sica, F. | Deposit date: | 2010-02-02 | Release date: | 2010-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish. Biochem.J., 433, 2010
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1Y92
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![BU of 1y92 by Molmil](/molmil-images/mine/1y92) | Crystal structure of the P19A/N67D Variant Of Bovine seminal Ribonuclease | Descriptor: | Seminal ribonuclease | Authors: | Picone, D, Di Fiore, A, Ercole, C, Franzese, M, Sica, F, Tomaselli, S, Mazzarella, L. | Deposit date: | 2004-12-14 | Release date: | 2004-12-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Role of the Hinge Loop in Domain Swapping: THE SPECIAL CASE OF BOVINE SEMINAL RIBONUCLEASE. J.Biol.Chem., 280, 2005
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1Y94
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![BU of 1y94 by Molmil](/molmil-images/mine/1y94) | Crystal structure of the G16S/N17T/P19A/S20A/N67D Variant Of Bovine seminal Ribonuclease | Descriptor: | Seminal ribonuclease | Authors: | Picone, D, Di Fiore, A, Ercole, C, Franzese, M, Sica, F, Tomaselli, S, Mazzarella, L. | Deposit date: | 2004-12-14 | Release date: | 2004-12-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Role of the Hinge Loop in Domain Swapping: THE SPECIAL CASE OF BOVINE SEMINAL RIBONUCLEASE. J.Biol.Chem., 280, 2005
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