1OVM
| Crystal structure of Indolepyruvate decarboxylase from Enterobacter cloacae | 分子名称: | Indole-3-pyruvate decarboxylase, MAGNESIUM ION, THIAMINE DIPHOSPHATE | 著者 | Schutz, A, Sandalova, T, Ricagno, S, Hubner, G, Konig, S, Schneider, G. | 登録日 | 2003-03-27 | 公開日 | 2003-06-03 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid Eur.J.Biochem., 270, 2003
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8OMI
| Crystal structure of the inositol hexakisphosphate kinase EhIP6KA M85 variant in complex with ATP and Mg2+ | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Schuetz, A, Aguirre, T, Fiedler, D. | 登録日 | 2023-03-31 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor. Elife, 12, 2023
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7ZIH
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor AG-01-128 | 分子名称: | 8-(1~{H}-benzimidazol-2-ylmethyl)-3-ethyl-7-(phenylmethyl)purine-2,6-dione, DI(HYDROXYETHYL)ETHER, FE (III) ION, ... | 著者 | Schuetz, A, Gogolin, A, Pfeifer, J, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2022-04-08 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.46890831 Å) | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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7ZIK
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7ZII
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-193 | 分子名称: | 8-(5~{H}-[1,3]dioxolo[4,5-f]benzimidazol-6-ylmethyl)-7-(phenylmethyl)-3-propyl-purine-2,6-dione, FE (III) ION, GLYCEROL, ... | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2022-04-08 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6280005 Å) | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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8CJL
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor TPT-004 | 分子名称: | 3-ethyl-8-[(2-methyl-5~{H}-imidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-(oxetan-3-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2023-02-13 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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7ZIJ
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-080 | 分子名称: | 8-(1~{H}-benzimidazol-2-ylmethyl)-3-cyclopropyl-7-(phenylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2022-04-08 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.94678366 Å) | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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8CJO
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-004 | 分子名称: | 1-[(3~{S})-3-(4-chloranyl-2-fluoranyl-phenyl)-1,4,8-triazatricyclo[7.4.0.0^{2,7}]trideca-2(7),8-dien-4-yl]-2-(2-ethyl-6-methyl-pyridin-3-yl)oxy-ethanone, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2023-02-13 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.86633706 Å) | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJM
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-047 | 分子名称: | 7-(cyclobutylmethyl)-3-ethyl-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2023-02-13 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJK
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-098 | 分子名称: | 3-ethyl-8-[(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2023-02-13 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.45914972 Å) | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJI
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-052 | 分子名称: | FE (III) ION, Tryptophan 5-hydroxylase 1, methyl (2~{S})-2-azanyl-3-[[3-[[3-ethyl-2,6-bis(oxidanylidene)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purin-7-yl]methyl]phenyl]carbonylamino]propanoate | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2023-02-13 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJJ
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-057 | 分子名称: | 3-ethyl-7-(phenylmethyl)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2023-02-13 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.66415656 Å) | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJN
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-070 | 分子名称: | 3-ethyl-7-[(4-phenylphenyl)methyl]-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2023-02-13 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.68080938 Å) | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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7ZIG
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-060 | 分子名称: | (2~{R})-2-azanyl-5-[[2-[[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]methyl]-1~{H}-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2022-04-08 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.808885 Å) | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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7ZIF
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-480 | 分子名称: | (2R)-2-azanyl-5-[[2-[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]sulfanyl-3H-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, GLYCEROL, ... | 著者 | Schuetz, A, Ziebart, N, Weise, M, Mallow, K, Pfeifer, J, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2022-04-08 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.86859715 Å) | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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3ULJ
| Crystal structure of apo Lin28B cold shock domain | 分子名称: | ACETATE ION, GLYCEROL, Lin28b, ... | 著者 | Mayr, F, Schuetz, A, Doege, N, Heinemann, U. | 登録日 | 2011-11-10 | 公開日 | 2012-08-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | The Lin28 cold-shock domain remodels pre-let-7 microRNA. Nucleic Acids Res., 40, 2012
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4A4I
| Crystal structure of the human Lin28b cold shock domain | 分子名称: | GLYCEROL, PROTEIN LIN-28 HOMOLOG B, SULFATE ION | 著者 | Mayr, F, Schuetz, A, Doege, N, Heinemann, U. | 登録日 | 2011-10-14 | 公開日 | 2012-08-08 | 最終更新日 | 2012-09-05 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Lin28 Cold-Shock Domain Remodels Pre-Let-7 Microrna. Nucleic Acids Res., 40, 2012
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4A76
| The Lin28b Cold shock domain in complex with heptathymidine | 分子名称: | 5'-D(*TP*TP*TP*TP*TP*TP*TP)-3', LIN28 COLD SHOCK DOMAIN | 著者 | Mayr, F, Schuetz, A, Doege, N, Heinemann, U. | 登録日 | 2011-11-11 | 公開日 | 2012-09-05 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | The Lin28 Cold-Shock Domain Remodels Pre-Let-7 Microrna. Nucleic Acids Res., 40, 2012
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4ALP
| The Lin28b Cold shock domain in complex with hexauridine | 分子名称: | GLYCEROL, HEXA URIDINE, LIN28 ISOFORM B | 著者 | Mayr, F, Schuetz, A, Doege, N, Heinemann, U. | 登録日 | 2012-03-05 | 公開日 | 2012-09-05 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | The Lin28 Cold-Shock Domain Remodels Pre-Let-7 Microrna. Nucleic Acids Res., 40, 2012
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4A75
| The Lin28b Cold shock domain in complex with hexathymidine. | 分子名称: | 5'-D(*TP*TP*TP*TP*TP*TP)-3', LIN28 COLD SHOCK DOMAIN, THIOCYANATE ION | 著者 | Mayr, F, Schuetz, A, Doege, N, Heinemann, U. | 登録日 | 2011-11-11 | 公開日 | 2012-09-05 | 最終更新日 | 2019-10-09 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The Lin28 Cold-Shock Domain Remodels Pre-Let-7 Microrna. Nucleic Acids Res., 40, 2012
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2YMA
| X-ray structure of the Yos9 dimerization domain | 分子名称: | PROTEIN OS-9 HOMOLOG | 著者 | Hanna, J, Schuetz, A, Zimmermann, F, Behlke, J, Sommer, T, Heinemann, U. | 登録日 | 2011-06-07 | 公開日 | 2012-01-25 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.545 Å) | 主引用文献 | Structural and Biochemical Basis of Yos9 Protein Dimerization and Possible Contribution to Self-Association of 3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase Degradation Ubiquitin-Ligase Complex. J.Biol.Chem., 287, 2012
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