8R4Y
 
 | | Homotrimer for the lumenal domain of Vacuolar Sorting Receptor 1 (VSR1) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Vacuolar-sorting receptor 1, alpha-D-mannopyranose, ... | | Authors: | Borges, R.J, Eldahshoury, M.K, Nettleship, J, Bird, L, An, J, Levada, A.J.L, Shah, N, Thomson, M, Fontes, M.R.M, Owens, R, Denecke, J, Postis, V, Uson, I, Goldman, A, De Marcos Lousa, C. | | Deposit date: | 2023-11-14 | | Release date: | 2025-08-13 | | Method: | X-RAY DIFFRACTION (3.51 Å) | | Cite: | The crystal structure of Vacuolar Sorting Receptor 1 (VSR1) lumenal domain reveals a stable domain-swapped trimer and a potential new cargo binding site
To Be Published
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9TM1
 | | Crystal structure of bromodomain from Plasmodium falciparum GCN5 complexed with a ligand | | Descriptor: | CHLORIDE ION, N-[(2S)-3-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-1-(methylamino)-1-oxidanylidene-propan-2-yl]-6-methoxy-3H-imidazo[4,5-b]pyridine-7-carboxamide, histone acetyltransferase | | Authors: | McMillan, J, Postis, V, Masson, G. | | Deposit date: | 2025-12-11 | | Release date: | 2026-04-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Residue-Level Determination of Small-Molecule-Protein Affinities by Hydrogen-Deuterium Exchange Mass Spectrometry.
J.Am.Soc.Mass.Spectrom., 2026
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8Q69
 | | Crystal structure of HsRNMT complexed with inhibitor DDD1060606 | | Descriptor: | 1-[(3~{S})-3-(2~{H}-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl]-2-thiophen-3-yl-ethanone, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Petit, A.P, Fyfe, P.K. | | Deposit date: | 2023-08-11 | | Release date: | 2024-08-21 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach.
Biochem.J., 482, 2025
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8Q8G
 | | Crystal structure of HsRNMT complexed with inhibitor DDD1870799 | | Descriptor: | 2-(4-fluorophenyl)-1-[(3~{S})-3-(6-oxidanyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl]ethanone, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Petit, A.P, Fyfe, P.K. | | Deposit date: | 2023-08-18 | | Release date: | 2024-08-28 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach.
Biochem.J., 482, 2025
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8Q9W
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8R2A
 | | CpKRS complexed with lysine and an inhibitor | | Descriptor: | 2-azanyl-4-(trifluoromethyl)-6-[[(1~{R},3~{S})-3-(trifluoromethyl)cyclohexyl]methyl]-7~{H}-pyrrolo[3,4-d]pyrimidin-5-one, DIMETHYL SULFOXIDE, GLYCEROL, ... | | Authors: | Dawson, A, Baragana, B, Caldwell, N. | | Deposit date: | 2023-11-03 | | Release date: | 2024-10-30 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy.
Sci Transl Med, 16, 2024
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8S00
 | | CpKRS complexed with lysine and an inhibitor | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-oxidanyl-~{N}-[(1-oxidanylcyclohexyl)methyl]-4-oxidanylidene-chromene-2-carboxamide, GLYCEROL, ... | | Authors: | Dawson, A, Baragana, B, Caldwell, N. | | Deposit date: | 2024-02-13 | | Release date: | 2024-11-06 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy.
Sci Transl Med, 16, 2024
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