1DS5
 
 | | DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME. | | 分子名称: | ADENOSINE MONOPHOSPHATE, CASEIN KINASE, ALPHA CHAIN, ... | | 著者 | Battistutta, R, Sarno, S, De Moliner, E, Marin, O, Zanotti, G, Pinna, L.A. | | 登録日 | 2000-01-07 | | 公開日 | 2001-01-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | | 主引用文献 | The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzyme.
Eur.J.Biochem., 267, 2000
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1F0Q
 | | CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF PROTEIN KINASE CK2 IN COMPLEX WITH THE NUCLEOTIDE COMPETITIVE INHIBITOR EMODIN | | 分子名称: | 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, PROTEIN KINASE CK2, ALPHA SUBUNIT | | 著者 | Battistutta, R, Sarno, S, De Moliner, E, Papinutto, E, Zanotti, G, Pinna, L.A. | | 登録日 | 2000-05-17 | | 公開日 | 2001-05-23 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2.
J.Biol.Chem., 275, 2000
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1ZOG
 | | Crystal structure of protein kinase CK2 in complex with TBB-derivatives | | 分子名称: | 4,5,6,7-TETRABROMO-2-(METHYLSULFANYL)-1H-BENZIMIDAZOLE, PROTEIN KINASE CK2, alpha SUBUNIT | | 著者 | Battistutta, R, Mazzorana, M, Sarno, S, Kazimierczuk, Z, Zanotti, G, Pinna, L.A. | | 登録日 | 2005-05-13 | | 公開日 | 2005-11-29 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
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1ZOH
 | | Crystal structure of protein kinase CK2 in complex with TBB-derivatives inhibitors | | 分子名称: | 1,2-ETHANEDIOL, 5,6,7,8-TETRABROMO-1-METHYL-2,3-DIHYDRO-1H-IMIDAZO[1,2-A]BENZIMIDAZOLE, CHLORIDE ION, ... | | 著者 | Battistutta, R, Mazzorana, M, Sarno, S, Kazimierczuk, Z, Zanotti, G, Pinna, L.A. | | 登録日 | 2005-05-13 | | 公開日 | 2005-11-29 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
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1ZOE
 | | Crystal structure of protein kinase CK2 in complex with TBB-derivatives inhibitors | | 分子名称: | 4,5,6,7-TETRABROMO-N,N-DIMETHYL-1H-BENZIMIDAZOL-2-AMINE, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Battistutta, R, Mazzorana, M, Sarno, S, Kazimierczuk, Z, Zanotti, G, Pinna, L.A. | | 登録日 | 2005-05-13 | | 公開日 | 2005-11-29 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
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1J91
 | | Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the ATP-competitive inhibitor 4,5,6,7-tetrabromobenzotriazole | | 分子名称: | 4,5,6,7-TETRABROMOBENZOTRIAZOLE, CASEIN KINASE II, ALPHA CHAIN | | 著者 | Battistutta, R, De Moliner, E, Sarno, S, Zanotti, G, Pinna, L.A. | | 登録日 | 2001-05-23 | | 公開日 | 2002-05-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.
Protein Sci., 10, 2001
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1JAM
 | | Crystal structure of apo-form of Z. Mays CK2 protein kinase alpha subunit | | 分子名称: | CASEIN KINASE II, ALPHA CHAIN | | 著者 | Battistutta, R, De Moliner, E, Sarno, S, Zanotti, G, Pinna, L.A. | | 登録日 | 2001-05-31 | | 公開日 | 2002-05-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.
Protein Sci., 10, 2001
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1M2R
 | | Crystal structure of 5,8-di-amino-1,4-di-hydroxy-anthraquinone/CK2 kinase complex | | 分子名称: | 5,8-DI-AMINO-1,4-DIHYDROXY-ANTHRAQUINONE, CASEIN kinase II, alpha chain | | 著者 | De Moliner, E, Moro, S, Sarno, S, Zagotto, G, Zanotti, G, Pinna, L.A, Battistutta, R. | | 登録日 | 2002-06-25 | | 公開日 | 2003-06-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Inhibition of protein kinase CK2 by anthraquinone-related compounds. A
structural insight
J.Biol.Chem., 278, 2003
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1M2P
 | | Crystal structure of 1,8-di-hydroxy-4-nitro-anthraquinone/CK2 kinase complex | | 分子名称: | 1,8-DI-HYDROXY-4-NITRO-ANTHRAQUINONE, Casein kinase II, alpha chain | | 著者 | De Moliner, E, Moro, S, Sarno, S, Zagotto, G, Zanotti, G, Pinna, L.A, Battistutta, R. | | 登録日 | 2002-06-25 | | 公開日 | 2003-06-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Inhibition of protein kinase CK2 by anthraquinone-related compounds. A
structural insight
J.Biol.Chem., 278, 2003
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1M2Q
 | | Crystal structure of 1,8-di-hydroxy-4-nitro-xanten-9-one/CK2 kinase complex | | 分子名称: | 1,8-DI-HYDROXY-4-NITRO-XANTHEN-9-ONE, Casein kinase II, alpha chain | | 著者 | De Moliner, E, Sarno, S, Moro, S, Zagotto, G, Zanotti, G, Pinna, L.A, Battistutta, R. | | 登録日 | 2002-06-25 | | 公開日 | 2003-06-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Inhibition of protein kinase CK2 by anthraquinone-related compounds. A
structural insight
J.Biol.Chem., 278, 2003
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3FL5
 | | Protein kinase CK2 in complex with the inhibitor Quinalizarin | | 分子名称: | 1,2,5,8-tetrahydroxyanthracene-9,10-dione, Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER | | 著者 | Mazzorana, M, Franchin, C, Battistutta, R. | | 登録日 | 2008-12-18 | | 公開日 | 2009-08-18 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2
Biochem.J., 421, 2009
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3KXH
 | | Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor (2-dymethylammino-4,5,6,7-tetrabromobenzoimidazol-1yl-acetic acid (K66) | | 分子名称: | Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER, [4,5,6,7-tetrabromo-2-(dimethylamino)-1H-benzimidazol-1-yl]acetic acid | | 著者 | Papinutto, E, Franchin, C, Battistutta, R. | | 登録日 | 2009-12-03 | | 公開日 | 2010-11-17 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
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3KXN
 | | Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor tetraiodobenzimidazole (K88) | | 分子名称: | 4,5,6,7-tetraiodo-1H-benzimidazole, Casein kinase II subunit alpha | | 著者 | Papinutto, E, Franchin, C, Battistutta, R. | | 登録日 | 2009-12-03 | | 公開日 | 2010-11-17 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
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3KXM
 | | Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor K74 | | 分子名称: | Casein kinase II subunit alpha, N-methyl-2-[(4,5,6,7-tetrabromo-1-methyl-1H-benzimidazol-2-yl)sulfanyl]acetamide | | 著者 | Papinutto, E, Franchin, C, Battistutta, R. | | 登録日 | 2009-12-03 | | 公開日 | 2010-11-17 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
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3KXG
 | | Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor 3,4,5,6,7-pentabromo-1H-indazole (K64) | | 分子名称: | 3,4,5,6,7-pentabromo-1H-indazole, Casein kinase II subunit alpha | | 著者 | Papinutto, E, Franchin, C, Battistutta, R. | | 登録日 | 2009-12-03 | | 公開日 | 2010-11-17 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
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6QS5
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4KWP
 | | Crystal Structure of Human CK2-alpha in complex with a benzimidazole inhibitor (K164) at 1.25 A resolution | | 分子名称: | 1,2-ETHANEDIOL, 4,5,6,7-tetrabromo-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1H-benzimidazole, Casein kinase II subunit alpha, ... | | 著者 | Ranchio, A, Lolli, G, Battistutta, R. | | 登録日 | 2013-05-24 | | 公開日 | 2014-04-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential.
Cell.Mol.Life Sci., 71, 2014
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1NA7
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1OM1
 | | Crystal structure of maize CK2 alpha in complex with IQA | | 分子名称: | (5-OXO-5,6-DIHYDRO-INDOLO[1,2-A]QUINAZOLIN-7-YL)-ACETIC ACID, Casein kinase II, alpha chain | | 著者 | Battistutta, R, De Moliner, E, Zanotti, G. | | 登録日 | 2003-02-24 | | 公開日 | 2004-02-24 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).
Biochem.J., 374, 2003
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1LP4
 | | Crystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein kinase CK2 | | 著者 | Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D. | | 登録日 | 2002-05-07 | | 公開日 | 2002-05-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
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1LPU
 | | Low Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays | | 分子名称: | BENZAMIDINE, Protein kinase CK2 | | 著者 | Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D. | | 登録日 | 2002-05-08 | | 公開日 | 2002-05-29 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
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1LR4
 | | Room Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays | | 分子名称: | BENZAMIDINE, Protein kinase CK2 | | 著者 | Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D. | | 登録日 | 2002-05-14 | | 公開日 | 2002-05-29 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
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1DAY
 | | CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN KINASE CK2 | | 著者 | Niefind, K, Puetter, M, Guerra, B, Issinger, O.G, Schomburg, D. | | 登録日 | 1999-11-01 | | 公開日 | 2000-05-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
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1DAW
 | | CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PROTEIN KINASE CK2 | | 著者 | Niefind, K, Puetter, M, Guerra, B, Issinger, O.G, Schomburg, D. | | 登録日 | 1999-11-01 | | 公開日 | 2000-05-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
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2OXX
 | | Protein kinase CK2 in complex with tetrabromobenzoimidazole derivatives K17, K22 and K32 | | 分子名称: | 4,5,6,7-TETRABROMO-1H,3H-BENZIMIDAZOL-2-THIONE, Casein kinase II subunit alpha | | 著者 | Battistutta, R, Zanotti, G, Cendron, L. | | 登録日 | 2007-02-21 | | 公開日 | 2007-09-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The ATP-Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules.
Chembiochem, 8, 2007
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