6H2O
 
 | | APO structure of Phenylalanine ammonia-lyase from Petroselinum crispum | | Descriptor: | Phenylalanine ammonia-lyase 1 | | Authors: | Molnar, B, Bata, Z, Leveles, I, Poppe, L, Vertessy, G.B. | | Deposit date: | 2018-07-14 | | Release date: | 2019-07-31 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Substrate Tunnel Engineering Aided by X-ray Crystallography and Functional Dynamics Swaps the Function of MIO-Enzymes
Acs Catalysis, 2021
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6HQF
 | | Structure of Phenylalanine ammonia-lyase from Petroselinum crispum in complex with (R)-APEP | | Descriptor: | Phenylalanine ammonia-lyase 1, [(1R)-1-amino-2-phenylethyl]phosphonic acid | | Authors: | Bata, Z, Molnar, B, Leveles, I, Poppe, L, Vertessy, G.B. | | Deposit date: | 2018-09-24 | | Release date: | 2019-10-09 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Substrate Tunnel Engineering Aided by X-ray Crystallography and Functional Dynamics Swaps the Function of MIO-Enzymes
Acs Catalysis, 2021
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6F6T
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9FIQ
 | | Structure-guided discovery of selective USP7 inhibitors with in vivo activity | | Descriptor: | 3-[[4-oxidanyl-1-[(3~{S},4~{S})-3-phenyl-1-(phenylmethyl)piperidin-4-yl]carbonyl-piperidin-4-yl]methyl]quinazolin-4-one, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Baker, L.M, Murray, J, Hubbard, R.E, Whitehead, N. | | Deposit date: | 2024-05-29 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
J.Med.Chem., 2024
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9FIR
 | | Structure-guided discovery of selective USP7 inhibitors with in vivo activity | | Descriptor: | 3-[[1-[(2~{S},3~{S})-1-methyl-6-oxidanylidene-2-phenyl-piperidin-3-yl]carbonyl-4-oxidanyl-piperidin-4-yl]methyl]quinazolin-4-one, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Baker, L.M, Murray, J, Hubbard, R.E, Whitehead, N. | | Deposit date: | 2024-05-29 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
J.Med.Chem., 2024
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9FIT
 | | Structure-guided discovery of selective USP7 inhibitors with in vivo activity | | Descriptor: | 7-methyl-3-[[4-oxidanyl-1-[(3~{R},4~{R})-3-phenyl-1-[(5-pyrimidin-5-ylthiophen-2-yl)methyl]piperidin-4-yl]carbonyl-piperidin-4-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-one, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Baker, L.M, Murray, J, Hubbard, R.E, Whitehead, N. | | Deposit date: | 2024-05-29 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
J.Med.Chem., 2024
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9FIU
 | | Structure-guided discovery of selective USP7 inhibitors with in vivo activity | | Descriptor: | 3-[[1-[(3~{R},4~{R})-1-[5-(3-methoxypyridin-4-yl)thiophen-2-yl]carbonyl-3-phenyl-piperidin-4-yl]carbonyl-4-oxidanyl-piperidin-4-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidin-4-one, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Baker, L.M, Murray, J, Hubbard, R.E, Whitehead, N. | | Deposit date: | 2024-05-29 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.37 Å) | | Cite: | Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
J.Med.Chem., 2024
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9FIO
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9FIP
 | | Structure-guided discovery of selective USP7 inhibitors with in vivo activity | | Descriptor: | 3-[[4-oxidanyl-1-[(1~{R},2~{R})-2-phenylcyclohexyl]carbonyl-piperidin-4-yl]methyl]quinazolin-4-one, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Baker, L.M, Murray, J, Hubbard, R.E, Whitehead, N. | | Deposit date: | 2024-05-29 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.06 Å) | | Cite: | Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
J.Med.Chem., 2024
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9FIS
 | | Structure-guided discovery of selective USP7 inhibitors with in vivo activity | | Descriptor: | 3-[[4-oxidanyl-1-[(3~{R},4~{R})-3-phenyl-1-(2-phenylethyl)piperidin-4-yl]carbonyl-piperidin-4-yl]methyl]quinazolin-4-one, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Baker, L.M, Murray, J, Hubbard, R.E, Whitehead, N. | | Deposit date: | 2024-05-29 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
J.Med.Chem., 2024
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9FIV
 | | Structure-guided discovery of selective USP7 inhibitors with in vivo activity | | Descriptor: | 7-methyl-3-[[4-oxidanyl-1-[(3~{R},4~{R})-3-phenyl-1-[(5-pyridin-4-yl-1,3-thiazol-2-yl)methyl]piperidin-4-yl]carbonyl-piperidin-4-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-one, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Baker, L.M, Murray, J, Hubbard, R.E, Whitehead, N. | | Deposit date: | 2024-05-29 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
J.Med.Chem., 2024
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