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A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure
分子名称:	DI(HYDROXYETHYL)ETHER, FORMIC ACID, GLYCEROL, ...
著者	Li, J.C, Nasertorabi, F, Xuan, W, Han, G.W, Stevens, R.C, Schultz, P.G.
登録日	2018-10-19
公開日	2019-06-26
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure. Acs Chem.Biol., 14, 2019

Crystal structure of PYK2 complexed with PF-2318841
分子名称:	5-{[4-{[2-(pyrrolidin-1-ylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,3-dihydro-2H-indol-2-one, PHOSPHATE ION, Protein tyrosine kinase 2 beta
著者	Han, S.
登録日	2008-10-07
公開日	2009-06-23
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation. Bioorg.Med.Chem.Lett., 18, 2008

Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog
分子名称:	4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide, Protein tyrosine kinase 2 beta, SULFATE ION
著者	Han, S, Mistry, A.
登録日	2009-04-16
公開日	2009-05-26
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity. Bioorg.Med.Chem.Lett., 19, 2009