8QBP
 
 | | Conformations of macrocyclic peptides sampled by exact NOEs: models for cell-permeability. NMR structure of Omphalotin A in methanol / water indoleOut conformation. | | Descriptor: | TRP-MVA-ILE-MVA-MVA-SAR-MVA-IML-SAR-VAL-IML-SAR | | Authors: | Ruedisser, S.H, Matabaro, E, Sonderegger, L, Guentert, P, Kuenzler, M, Gossert, A.D. | | Deposit date: | 2023-08-25 | | Release date: | 2023-12-13 | | Last modified: | 2024-01-03 | | Method: | SOLUTION NMR | | Cite: | Conformations of Macrocyclic Peptides Sampled by Nuclear Magnetic Resonance: Models for Cell-Permeability.
J.Am.Chem.Soc., 145, 2023
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2MN5
 | | NMR structure of Copsin | | Descriptor: | Copsin | | Authors: | Hofmann, D, Wider, G, Essig, A, Aebi, M. | | Deposit date: | 2014-03-28 | | Release date: | 2014-10-29 | | Last modified: | 2019-12-25 | | Method: | SOLUTION NMR | | Cite: | Copsin, a Novel Peptide-based Fungal Antibiotic Interfering with the Peptidoglycan Synthesis.
J.Biol.Chem., 289, 2014
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6R00
 | | OphA DeltaC6 V404F complex with SAH | | Descriptor: | PHE-PRO-TRP-MVA-ILE-MVA-PHE-GLY-VAL-ILE-GLY-VAL-ILE-GLY, Peptide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Song, H, Naismith, J.H. | | Deposit date: | 2019-03-12 | | Release date: | 2020-04-01 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Substrate Plasticity of a Fungal Peptide alpha-N-Methyltransferase.
Acs Chem.Biol., 15, 2020
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6QZY
 | | full length OphA V406P in complex with SAH | | Descriptor: | ASN-GLY-PHE-PRO-TRP-MVA-ILE-MVA-VAL-GLY-PRO-ILE-GLY, MAGNESIUM ION, Peptide N-methyltransferase, ... | | Authors: | Song, H, Naismith, J.H. | | Deposit date: | 2019-03-12 | | Release date: | 2020-04-01 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Substrate Plasticity of a Fungal Peptide alpha-N-Methyltransferase.
Acs Chem.Biol., 15, 2020
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6QZZ
 | | full length OphA V404E in complex with SAH | | Descriptor: | Peptide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Song, H, Naismith, J.H. | | Deposit date: | 2019-03-12 | | Release date: | 2020-04-01 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Substrate Plasticity of a Fungal Peptide alpha-N-Methyltransferase.
Acs Chem.Biol., 15, 2020
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7ZB0
 | | macrocyclase OphP with 15mer | | Descriptor: | 1,2-ETHANEDIOL, 15mer, BICARBONATE ION, ... | | Authors: | Song, H, Naismith, J.H. | | Deposit date: | 2022-03-23 | | Release date: | 2022-07-06 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Molecular basis for the enzymatic macrocyclization of multiply backbone N-methylated peptides
Biorxiv, 2022
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7ZB1
 | | S580A with 18mer | | Descriptor: | 1,2-ETHANEDIOL, 18mer, BICARBONATE ION, ... | | Authors: | Song, H, Naismith, J.H. | | Deposit date: | 2022-03-23 | | Release date: | 2022-07-06 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular basis for the enzymatic macrocyclization of multiply backbone N-methylated peptides
Biorxiv, 2022
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7ZAZ
 | | macrocyclase OphP with ZPP | | Descriptor: | 1,2-ETHANEDIOL, BICARBONATE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Song, H, Naismith, J.H. | | Deposit date: | 2022-03-23 | | Release date: | 2022-07-06 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular basis for the enzymatic macrocyclization of multiply backbone N-methylated peptides
Biorxiv, 2022
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7ZB2
 | | apo macrocyclase OphP | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Song, H, Naismith, J.H. | | Deposit date: | 2022-03-23 | | Release date: | 2022-07-06 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Molecular basis for the enzymatic macrocyclization of multiply backbone N-methylated peptides
Biorxiv, 2022
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5N0N
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5N0U
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5N0P
 | | Crystal structure of OphA-DeltaC18 in complex with SAH | | Descriptor: | 1,2-ETHANEDIOL, S-ADENOSYL-L-HOMOCYSTEINE, peptide N-methyltranferase | | Authors: | Naismith, J.H, Song, H. | | Deposit date: | 2017-02-03 | | Release date: | 2018-02-14 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds.
Sci Adv, 4, 2018
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5N0X
 | | Crystal structure of OphA-DeltaC6 in complex with SAM | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Peptide N-Methyltransferase, ... | | Authors: | Song, H, Naismith, J.H. | | Deposit date: | 2017-02-03 | | Release date: | 2018-02-14 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds.
Sci Adv, 4, 2018
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5N0T
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5N0S
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5N0R
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5N4I
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5OUF
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