8TR5
| Cryo-EM structure of the rat P2X7 receptor in the apo closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
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8TRJ
| Cryo-EM structure of the rat P2X7 receptor in complex with the high-affinity agonist BzATP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-(4-benzoylbenzoyl)adenosine 5'-(tetrahydrogen triphosphate), GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
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8V4S
| Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | Deposit date: | 2023-11-29 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
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8TRK
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist methyl blue | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4',4''-[methanetriyltris(4,1-phenyleneazanediyl)]tri(benzene-1-sulfonic acid), GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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8TR8
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist AZD9056 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[(3s,5s,7s)-adamantan-1-yl]methyl}-2-chloro-5-{3-[(3-hydroxypropyl)amino]propyl}benzamide, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.21 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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8TRB
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist JNJ47965567 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamide, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.36 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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8TRA
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist GSK1482160 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxo-L-prolinamide, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.41 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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8TR7
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A839977 | Descriptor: | (1P)-1-(2,3-dichlorophenyl)-N-({2-[(pyridin-2-yl)oxy]phenyl}methyl)-1H-tetrazol-5-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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8TR6
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A438079 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{[(5R)-5-(2,3-dichlorophenyl)tetrazolidin-1-yl]methyl}pyridine, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.18 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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