7ZIJ
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-080 | 分子名称: | 8-(1~{H}-benzimidazol-2-ylmethyl)-3-cyclopropyl-7-(phenylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2022-04-08 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.94678366 Å) | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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7ZIG
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-060 | 分子名称: | (2~{R})-2-azanyl-5-[[2-[[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]methyl]-1~{H}-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2022-04-08 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.808885 Å) | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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7ZIF
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-480 | 分子名称: | (2R)-2-azanyl-5-[[2-[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]sulfanyl-3H-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, GLYCEROL, ... | 著者 | Schuetz, A, Ziebart, N, Weise, M, Mallow, K, Pfeifer, J, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2022-04-08 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.86859715 Å) | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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2AAE
| THE ROLE OF HISTIDINE-40 IN RIBONUCLEASE T1 CATALYSIS: THREE-DIMENSIONAL STRUCTURES OF THE PARTIALLY ACTIVE HIS40LYS MUTANT | 分子名称: | CALCIUM ION, PHOSPHATE ION, RIBONUCLEASE T1 | 著者 | Zegers, I, Verhelst, P, Choe, C.W, Steyaert, J, Heinemann, U, Wyns, L, Saenger, W. | 登録日 | 1992-09-15 | 公開日 | 1994-01-31 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant. Biochemistry, 31, 1992
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2AAD
| THE ROLE OF HISTIDINE-40 IN RIBONUCLEASE T1 CATALYSIS: THREE-DIMENSIONAL STRUCTURES OF THE PARTIALLY ACTIVE HIS40LYS MUTANT | 分子名称: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1 ISOZYME | 著者 | Zegers, I, Verhelst, P, Choe, C.W, Steyaert, J, Heinemann, U, Wyns, L, Saenger, W. | 登録日 | 1992-09-15 | 公開日 | 1994-01-31 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant. Biochemistry, 31, 1992
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3KXC
| Mutant transport protein | 分子名称: | PALMITIC ACID, Trafficking protein particle complex subunit 3, Trafficking protein particle complex subunit 6B | 著者 | Kummel, D, Heinemann, U. | 登録日 | 2009-12-02 | 公開日 | 2010-04-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Characterization of the self-palmitoylation activity of the transport protein particle component Bet3 Cell.Mol.Life Sci., 67, 2010
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3O5N
| Tetrahydroquinoline carboxylates are potent inhibitors of the Shank PDZ domain, a putative target in autism disorders | 分子名称: | (3aS,4R,9bR)-9-nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4,6-dicarboxylic acid, SH3 and multiple ankyrin repeat domains protein 3 | 著者 | Saupe, J, Roske, Y, Schillinger, C, Kamdem, N, Radetzki, S, Diehl, A, Oschkinat, H, Krause, G, Heinemann, U, Rademann, J. | 登録日 | 2010-07-28 | 公開日 | 2011-06-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the shank3 PDZ domain. Chemmedchem, 6, 2011
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4XNF
| Tailspike protein double mutant D339A/E372Q of E. coli bacteriophage HK620 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-15 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XOP
| Tailspike protein double mutant D339N/E372Q of E. coli bacteriophage HK620 in complex with hexasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-16 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XMY
| Tailspike protein double mutant D339A/E372A of E. coli bacteriophage HK620 in complex with pentasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-15 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XKV
| Tailspike protein mutant D339N of E. coli bacteriophage HK620 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-12 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XL9
| Tailspike protein mutant D339A of E. coli bacteriophage HK620 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-13 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XOR
| Tailspike protein double mutant D339N/E372Q of E. coli bacteriophage HK620 in complex with pentasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-16 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XLC
| Tailspike protein double mutant D339N/E372A of E. coli bacteriophage HK620 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-13 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XLF
| Tailspike protein double mutant D339N/E372A of E. coli bacteriophage HK620 in complex with pentasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-13 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XN0
| Tailspike protein mutant E372A of E. coli bacteriophage HK620 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-15 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XLE
| Tailspike protein double mutant D339N/E372A of E. coli bacteriophage HK620 in complex with hexasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-13 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XKW
| Tailspike protein mutant D339N of E. coli bacteriophage HK620 in complex with pentasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-12 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XLA
| Tailspike protein mutant D339A of E. coli bacteriophage HK620 IN COMPLEX WITH PENTASACCHARIDE | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-13 | 公開日 | 2016-01-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XM3
| Tailspike protein mutant E372A of E. coli bacteriophage HK620 in complex with pentasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-14 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XN3
| Tailspike protein mutant E372A of E. coli bacteriophage HK620 in complex with hexasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-15 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XON
| Tailspike protein double mutant D339N/E372Q of E. coli bacteriophage HK620 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-16 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XR6
| Tailspike protein double mutant D339A/E372Q of E. coli bacteriophage HK620 in complex with hexasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-20 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XLH
| Tailspike protein double mutant D339A/E372A of E. coli bacteriophage HK620 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-13 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XOT
| Tailspike protein mutant E372Q of E. coli bacteriophage HK620 in complex with pentasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | 著者 | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2015-01-16 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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