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SIV INTEGRASE (CATALYTIC DOMAIN + DNA BIDING DOMAIN COMPRISING RESIDUES 50-293) MUTANT WITH PHE 185 REPLACED BY HIS (F185H)
分子名称:	PROTEIN (SIU89134), PROTEIN (SIV INTEGRASE)
著者	Chen, Z, Yan, Y, Munshi, S, Li, Y, Zruygay-Murphy, J, Xu, B, Witmer, M, Felock, P, Wolfe, A, Sardana, V, Emini, E.A, Hazuda, D, Kuo, L.C.
登録日	1999-12-21
公開日	2000-12-27
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform. J.Mol.Biol., 296, 2000

Crystal Structure of human Beta Secretase complexed with IXS
分子名称:	Beta-secretase 1, N-[(1S)-1-benzyl-2-{[(1S)-2-(isobutylamino)-1-methyl-2-oxoethyl]amino}ethyl]-N'-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide
著者	Munshi, S.
登録日	2007-08-16
公開日	2008-04-22
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres Bioorg.Med.Chem.Lett., 16, 2006

Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor
分子名称:	Beta-secretase 1, N-(4-{[4-(cyclohexylamino)-1-(3-fluorophenyl)-2-oxo-1,3,8-triazaspiro[4.5]dec-3-en-8-yl]methyl}phenyl)acetamide
著者	Munshi, S.
登録日	2008-12-17
公開日	2009-01-20
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Discovery and X-ray Crystallographic Analysis of a Iminohydantoin Inhibitor of beta-Secretase J.Med.Chem., 51, 2008