8AM0
 
 | | Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib) | | Descriptor: | (2R)-2-[[2-[(4S)-4-[bis(fluoranyl)methyl]-2-oxidanylidene-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | Authors: | Goncalves, M, Johnson, J.L, Roewer, K.M. | | Deposit date: | 2022-08-02 | | Release date: | 2023-12-13 | | Last modified: | 2024-01-03 | | Method: | X-RAY DIFFRACTION (2.818 Å) | | Cite: | Epinephrine inhibits PI3K alpha via the Hippo kinases.
Cell Rep, 42, 2023
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9DKW
 | | Human mitochondrial ClpP in complex with Bortezomib | | Descriptor: | ATP-dependent Clp protease proteolytic subunit, mitochondrial, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | | Authors: | Uday, A.B, Zeytuni, N, Goncalves, M, Vahidi, S. | | Deposit date: | 2024-09-10 | | Release date: | 2025-04-23 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (2.49 Å) | | Cite: | Mechanism of allosteric activation in human mitochondrial ClpP protease.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9DKV
 | | Human mitochondrial ClpP in Apo state | | Descriptor: | ATP-dependent Clp protease proteolytic subunit, mitochondrial | | Authors: | Uday, A.B, Zeytuni, N, Goncalves, M, Vahidi, S. | | Deposit date: | 2024-09-10 | | Release date: | 2025-04-23 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Mechanism of allosteric activation in human mitochondrial ClpP protease.
Proc.Natl.Acad.Sci.USA, 122, 2025
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