8V0F
 
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9D28
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9D29
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9D2A
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9DM6
 | | Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with an ethylhydrazide inhibitor | | Descriptor: | 1,2-ETHANEDIOL, Hdac6 protein, N-[2-(benzylamino)-2-oxoethyl]-4-(dimethylamino)-N-{[4-(2-ethylhydrazine-1-carbonyl)phenyl]methyl}benzamide, ... | | Authors: | Gaynes, M.N, Watson, P.R, Konig, B, Christianson, D.W. | | Deposit date: | 2024-09-12 | | Release date: | 2025-02-26 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties.
J.Med.Chem., 68, 2025
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9MHS
 | | Drimenol synthase | | Descriptor: | DI(HYDROXYETHYL)ETHER, Drimenol Synthase, GLYCEROL, ... | | Authors: | Osika, K.R, Gaynes, M.N, Christianson, D.W. | | Deposit date: | 2024-12-12 | | Release date: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Crystal structure and catalytic mechanism of drimenol synthase, an unusual bifunctional terpene cyclase-phosphatase.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9MLO
 | | Drimenol Synthase - Farnesyl Thiol Complex | | Descriptor: | (2E,6E)-3,7,11-trimethyldodeca-2,6,10-triene-1-thiol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | | Authors: | Osika, K.R, Gaynes, M.N, Christianson, D.W. | | Deposit date: | 2024-12-19 | | Release date: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Crystal structure and catalytic mechanism of drimenol synthase, an unusual bifunctional terpene cyclase-phosphatase.
Proc.Natl.Acad.Sci.USA, 122, 2025
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