9GIW
 
 | | Structure of the human mitochondrial pyruvate carrier inhibited by zaprinast | | Descriptor: | 5-(2-propoxyphenyl)-3,4-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one, Mitochondrial pyruvate carrier 1-like protein, Mitochondrial pyruvate carrier 2, ... | | Authors: | Sichrovsky, M, Lacabanne, D, Ruprecht, J.J, Rana, J.J, Stanik, K, Dionysopoulou, M, Sowton, A.P, King, M.S, Jones, S, Cooper, L, Hardwick, S.W, Paris, G, Chirgadze, D.Y, Ding, S, Fearnley, I.M, Palmer, S, Pardon, E, Steyaert, J, Leone, V, Forrest, L.R, Tavoulari, S, Kunji, E.R.S. | | Deposit date: | 2024-08-19 | | Release date: | 2025-05-07 | | Method: | ELECTRON MICROSCOPY (3.92 Å) | | Cite: | Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier.
Sci Adv, 11, 2025
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9GIV
 | | Structure of the human mitochondrial pyruvate carrier inhibited by a UK5099-derivative | | Descriptor: | (~{E})-2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]prop-2-enoic acid, Mitochondrial pyruvate carrier 1-like protein, Mitochondrial pyruvate carrier 2, ... | | Authors: | Sichrovsky, M, Lacabanne, D, Ruprecht, J.J, Rana, J.J, Stanik, K, Dionysopoulou, M, Sowton, A.P, King, M.S, Jones, S, Cooper, L, Hardwick, S.W, Paris, G, Chirgadze, D.Y, Ding, S, Fearnley, I.M.F, Palmer, S, Pardon, E, Steyaert, J, Leone, V, Forrest, L.R, Tavoulari, S, Kunji, E.R.S. | | Deposit date: | 2024-08-19 | | Release date: | 2025-05-07 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier.
Sci Adv, 11, 2025
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9GIY
 | | Structure of the human mitochondrial pyruvate carrier inhibited by mitoglitazone | | Descriptor: | Macrobody,Maltose/maltodextrin-binding periplasmic protein, Mitochondrial pyruvate carrier 1-like protein, Mitochondrial pyruvate carrier 2, ... | | Authors: | Sichrovsky, M, Lacabanne, D, Ruprecht, J.J, Rana, J.J, Stanik, K, Dionysopoulou, M, King, M.S, Sowton, A.P, Jones, S, Cooper, L, Hardwick, S.W, Paris, G, Chirgadze, D.Y, Ding, S, Fearnley, I.M, Palmer, S, Pardon, E, Steyaert, J, Leone, V, Forrest, L.R, Tavoulari, S, Kunji, E.R.S. | | Deposit date: | 2024-08-19 | | Release date: | 2025-05-07 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier.
Sci Adv, 11, 2025
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9GIX
 | | Structure of the human mitochondrial pyruvate carrier in the apo-state | | Descriptor: | MBP-nanobody,Maltose/maltodextrin-binding periplasmic protein, Mitochondrial pyruvate carrier 1-like protein, Mitochondrial pyruvate carrier 2 | | Authors: | Sichrovsky, M, Lacabanne, D, Ruprecht, J.J, Rana, J.J, Stanik, K, Dionysopoulou, M, Sowton, A.P, King, M.S, Jones, S, Cooper, L, Hardwick, S.W, Paris, G, Chirgadze, D.Y, Ding, S, Fearnley, I.M, Palmer, S, Pardon, E, Steyaert, J, Leone, V, Forrest, L.R, Tavoulari, S, Kunji, E.R.S. | | Deposit date: | 2024-08-19 | | Release date: | 2025-05-07 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier.
Sci Adv, 11, 2025
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4UVM
 | | In meso crystal structure of the POT family transporter PepTSo | | Descriptor: | (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, GLUTATHIONE UPTAKE TRANSPORTER | | Authors: | Lyons, J.A, Solcan, N, Caffrey, M, Newstead, S. | | Deposit date: | 2014-08-07 | | Release date: | 2015-02-04 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Gating Topology of the Proton-Coupled Oligopeptide Symporters.
Structure, 23, 2015
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4LLH
 | | Substrate bound outward-open state of the symporter BetP | | Descriptor: | 2-(trimethyl-lambda~5~-arsanyl)ethanol, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, CHLORIDE ION, ... | | Authors: | Perez, C, Faust, B, Ziegler, C. | | Deposit date: | 2013-07-09 | | Release date: | 2014-05-07 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na(+) coupling.
Nat Commun, 5, 2014
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