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8OTK
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BU of 8otk by Molmil
Structure of ClpC Q11P N-terminal Domain
Descriptor: ATP-dependent Clp protease ATP-binding subunit ClpC / Negative regulator of tic competence clcC/mecB, CARBONATE ION, GLYCEROL, ...
Authors:Evans, N.J, Isaacson, R.L, Camp, A.H.
Deposit date:2023-04-21
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:A novel ClpC-ClpP adaptor protein that functions in the developing Bacillus subtilis spore
To Be Published
8B3S
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BU of 8b3s by Molmil
Structure of YjbA in complex with ClpC N-terminal Domain
Descriptor: ATP-dependent Clp protease ATP-binding subunit ClpC / Negative regulator of tic competence clcC/mecB, GLYCEROL, MAGNESIUM ION, ...
Authors:Evans, N.J, Isaacson, R.L, Camp, A.H, Collins, M.K.
Deposit date:2022-09-16
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure of YjbA in complex with ClpC N-terminal Domain
To Be Published
8B3Z
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BU of 8b3z by Molmil
SigE N-terminal Domain
Descriptor: RNA polymerase sigma factor
Authors:Evans, N.J, Isaacson, R.L, Collins, K.M, Camp, A.H.
Deposit date:2022-09-18
Release date:2023-08-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Analysis of Bacillus subtilis Sigma Factors.
Microorganisms, 11, 2023
5LYN
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BU of 5lyn by Molmil
Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment
Descriptor: PRO-THR-VAL-GLU-GLU-VAL-ASP, Small glutamine-rich tetratricopeptide repeat-containing protein 2, ZINC ION
Authors:Krysztofinska, E.M, Evans, N.J, Thapaliya, A, Murray, J.W, Morgan, R.M.L, Martinez-Lumbreras, S, Isaacson, R.L.
Deposit date:2016-09-28
Release date:2017-10-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp.
Front Mol Biosci, 4, 2017
5AJW
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BU of 5ajw by Molmil
Human PFKFB3 in complex with an indole inhibitor 2
Descriptor: 2-amino-N-[4-(2-amino-1-benzyl-3-cyano-indol-5-yl)oxyphenyl]acetamide, 6-O-phosphono-beta-D-fructofuranose, 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, ...
Authors:Boyd, S, Brookfield, J.L, Critchlow, S.E, Cumming, I.A, Curtis, N.J, Debreczeni, J.E, Degorce, S.L, Donald, C, Evans, N.J, Groombridge, S, Hopcroft, P, Jones, N.P, Kettle, J.G, Lamont, S, Lewis, H.J, MacFaull, P, McLoughlin, S.B, Rigoreau, L.J.M, Smith, J.M, St-Gallay, S, Stock, J.K, Wheatley, E.R, Winter, J, Wingfield, J.
Deposit date:2015-02-27
Release date:2015-04-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3.
J.Med.Chem., 58, 2015
5AJZ
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BU of 5ajz by Molmil
Human PFKFB3 in complex with an indole inhibitor 5
Descriptor: 2-azanyl-N-[4-[(3-cyano-1H-indol-5-yl)oxy]phenyl]ethanamide, 6-O-phosphono-beta-D-fructofuranose, 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, ...
Authors:Boyd, S, Brookfield, J.L, Critchlow, S.E, Cumming, I.A, Curtis, N.J, Debreczeni, J.E, Degorce, S.L, Donald, C, Evans, N.J, Groombridge, S, Hopcroft, P, Jones, N.P, Kettle, J.G, Lamont, S, Lewis, H.J, MacFaull, P, McLoughlin, S.B, Rigoreau, L.J.M, Smith, J.M, St-Gallay, S, Stock, J.K, Wheatley, E.R, Winter, J, Wingfield, J.
Deposit date:2015-02-27
Release date:2015-04-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3.
J.Med.Chem., 58, 2015
5AJY
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BU of 5ajy by Molmil
Human PFKFB3 in complex with an indole inhibitor 4
Descriptor: 6-O-phosphono-beta-D-fructofuranose, 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, N-(4-{[3-(1-methyl-1H-pyrazol-4-yl)-1H-indol-5-yl]oxy}phenyl)glycinamide, ...
Authors:Boyd, S, Brookfield, J.L, Critchlow, S.E, Cumming, I.A, Curtis, N.J, Debreczeni, J.E, Degorce, S.L, Donald, C, Evans, N.J, Groombridge, S, Hopcroft, P, Jones, N.P, Kettle, J.G, Lamont, S, Lewis, H.J, MacFaull, P, McLoughlin, S.B, Rigoreau, L.J.M, Smith, J.M, St-Gallay, S, Stock, J.K, Wheatley, E.R, Winter, J, Wingfield, J.
Deposit date:2015-02-27
Release date:2015-04-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3.
J.Med.Chem., 58, 2015
5AJV
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BU of 5ajv by Molmil
Human PFKFB3 in complex with an indole inhibitor 1
Descriptor: (2S)-2-amino-N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]-3-hydroxy-propanamide, 2,6-di-O-phosphono-beta-D-fructofuranose, HUMAN PFKFB3, ...
Authors:Boyd, S, Brookfield, J.L, Critchlow, S.E, Cumming, I.A, Curtis, N.J, Debreczeni, J.E, Degorce, S.L, Donald, C, Evans, N.J, Groombridge, S, Hopcroft, P, Jones, N.P, Kettle, J.G, Lamont, S, Lewis, H.J, MacFaull, P, McLoughlin, S.B, Rigoreau, L.J.M, Smith, J.M, St-Gallay, S, Stock, J.K, Wheatley, E.R, Winter, J, Wingfield, J.
Deposit date:2015-02-27
Release date:2015-04-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3.
J.Med.Chem., 58, 2015
5AJX
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BU of 5ajx by Molmil
Human PFKFB3 in complex with an indole inhibitor 3
Descriptor: (2S)-N-[4-[3-cyano-1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamide, 6-O-phosphono-beta-D-fructofuranose, 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, ...
Authors:Boyd, S, Brookfield, J.L, Critchlow, S.E, Cumming, I.A, Curtis, N.J, Debreczeni, J.E, Degorce, S.L, Donald, C, Evans, N.J, Groombridge, S, Hopcroft, P, Jones, N.P, Kettle, J.G, Lamont, S, Lewis, H.J, MacFaull, P, McLoughlin, S.B, Rigoreau, L.J.M, Smith, J.M, St-Gallay, S, Stock, J.K, Wheatley, E.R, Winter, J, Wingfield, J.
Deposit date:2015-02-27
Release date:2015-04-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3.
J.Med.Chem., 58, 2015
5AK0
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BU of 5ak0 by Molmil
Human PFKFB3 in complex with an indole inhibitor 6
Descriptor: (2S)-N-[4-[1-METHYL-3-(1-METHYLPYRAZOL-4-YL)INDOL-5-YL]OXYPHENYL]PYRROLIDINE-2-CARBOXAMIDE, 6-O-phosphono-beta-D-fructofuranose, 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, ...
Authors:Boyd, S, Brookfield, J.L, Critchlow, S.E, Cumming, I.A, Curtis, N.J, Debreczeni, J.E, Degorce, S.L, Donald, C, Evans, N.J, Groombridge, S, Hopcroft, P, Jones, N.P, Kettle, J.G, Lamont, S, Lewis, H.J, MacFaull, P, McLoughlin, S.B, Rigoreau, L.J.M, Smith, J.M, St-Gallay, S, Stock, J.K, Wheatley, E.R, Winter, J, Wingfield, J.
Deposit date:2015-02-27
Release date:2015-04-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3.
J.Med.Chem., 58, 2015
5LYP
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BU of 5lyp by Molmil
Crystal structure of the Tpr Domain of Sgt2.
Descriptor: BORATE ION, Small glutamine-rich tetratricopeptide repeat-containing protein 2
Authors:Krysztofinska, E.M, Morgan, R.M.L, Thapaliya, A, Evans, N.J, Murray, J.W, Martinez-Lumbreras, S, Isaacson, R.L.
Deposit date:2016-09-28
Release date:2017-10-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp.
Front Mol Biosci, 4, 2017
5NGE
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BU of 5nge by Molmil
Crystal structure of USP7 in complex with the non-covalent inhibitor, FT671
Descriptor: 5-[[1-[(3~{S})-4,4-bis(fluoranyl)-3-(3-fluoranylpyrazol-1-yl)butanoyl]-4-oxidanyl-piperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Turnbull, A.P, Krajewski, W.W, Ioannidis, S, Kessler, B.M, Komander, D.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
5NGF
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BU of 5ngf by Molmil
Crystal structure of USP7 in complex with the covalent inhibitor, FT827
Descriptor: 1,2-ETHANEDIOL, Ubiquitin carboxyl-terminal hydrolase 7, ~{N}-[2-[4-[4-[(1-methyl-4-oxidanylidene-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]-4-oxidanyl-piperidin-1-yl]carbonylphenyl]phenyl]ethanesulfonamide
Authors:Krajewski, W.W, Turnbull, A.P, Ioannidis, S, Kessler, B.M, Komander, D.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
5N7Y
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BU of 5n7y by Molmil
Solution structure of B. subtilis Sigma G inhibitor CsfB
Descriptor: Anti-sigma-G factor Gin, ZINC ION
Authors:Martinez-Lumbreras, S, Alfano, C, Atkinson, A, Isaacson, R.L.
Deposit date:2017-02-21
Release date:2018-02-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural and Functional Insights into Bacillus subtilis Sigma Factor Inhibitor, CsfB.
Structure, 26, 2018
2N9P
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BU of 2n9p by Molmil
Solution structure of RNF126 N-terminal zinc finger domain in complex with BAG6 Ubiquitin-like domain
Descriptor: E3 ubiquitin-protein ligase RNF126, Large proline-rich protein BAG6, ZINC ION
Authors:Martinez-Lumbreras, S, Krysztofinska, E.M, Thapaliya, A, Isaacson, R.L.
Deposit date:2015-12-01
Release date:2016-05-25
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural and functional insights into the E3 ligase, RNF126.
Sci Rep, 6, 2016
2N9O
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BU of 2n9o by Molmil
Solution structure of RNF126 N-terminal zinc finger domain
Descriptor: E3 ubiquitin-protein ligase RNF126, ZINC ION
Authors:Martinez-Lumbreras, S, Krysztofinska, E.M, Thapaliya, A, Isaacson, R.L.
Deposit date:2015-12-01
Release date:2016-05-25
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural and functional insights into the E3 ligase, RNF126.
Sci Rep, 6, 2016

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