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1YU9
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GppNHp-Bound Rab4A
分子名称: GTP-binding protein, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-02-13
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
2HV8
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BU of 2hv8 by Molmil
Crystal structure of GTP-bound Rab11 in complex with FIP3
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Eathiraj, S, Mishra, A, Prekeris, R, Lambright, D.G.
登録日2006-07-27
公開日2006-11-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structural Basis for Rab11-mediated Recruitment of FIP3 to Recycling Endosomes.
J.Mol.Biol., 364, 2006
3RHK
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BU of 3rhk by Molmil
Crystal structure of the catalytic domain of c-Met kinase in complex with ARQ 197
分子名称: 1-[(3R,4R)-4-(1H-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium, Hepatocyte growth factor receptor
著者Eathiraj, S, Palma, R, Volckova, E, Hirschi, M, France, D.S, Ashwell, M.A, Chan, T.C.
登録日2011-04-11
公開日2011-04-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197.
J.Biol.Chem., 286, 2011
3RHX
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Crystal structure of the catalytic domain of FGFR1 kinase in complex with ARQ 069
分子名称: (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine, 1,2-ETHANEDIOL, Basic fibroblast growth factor receptor 1, ...
著者Eathiraj, S, Palma, R, Hirschi, M, Volckova, E, Nakuci, E, Castro, J, Chen, C.R, Chan, T.C, France, D.S, Ashwell, M.A.
登録日2011-04-12
公開日2011-05-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor.
J.Biol.Chem., 286, 2011
3RI1
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Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069
分子名称: (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine, Fibroblast growth factor receptor 2, SULFATE ION
著者Eathiraj, S, Palma, R, Hirschi, M, Volckova, E, Nakuci, E, Castro, J, Chen, C.R, Chan, T.C, France, D.S, Ashwell, M.A.
登録日2011-04-12
公開日2011-05-04
最終更新日2011-10-19
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor.
J.Biol.Chem., 286, 2011
1YZK
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BU of 1yzk by Molmil
GppNHp bound Rab11 GTPase
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-11A
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-02-28
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZU
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BU of 1yzu by Molmil
GppNHp-Bound Rab21 GTPase at 2.50 A Resolution
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-21
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-02-28
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0A
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GDP-Bound Rab2A GTPase
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-2A
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-01
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZN
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GppNHp-Bound Ypt1p GTPase
分子名称: GTP-binding protein YPT1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-02-28
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0J
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Structure of GTP-Bound Rab22Q64L GTPase in complex with the minimal Rab binding domain of Rabenosyn-5
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FYVE-finger-containing Rab5 effector protein rabenosyn-5, GLYCEROL, ...
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-01
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z08
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GppNHp-Bound Rab21 Q53G mutant GTPase
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-21
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-01
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0K
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Structure of GTP-Bound Rab4Q67L GTPase in complex with the central Rab binding domain of Rabenosyn-5
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FYVE-finger-containing Rab5 effector protein rabenosyn-5, GTP-binding protein, ...
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-01
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z22
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GDP-Bound Rab23 GTPase crystallized in C222(1) space group
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-23
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-07
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z07
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GppNHp-Bound Rab5c G55Q mutant GTPase
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-5C
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-01
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZL
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BU of 1yzl by Molmil
GppNHp-Bound Rab9 GTPase
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-9A
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-02-28
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0I
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GDP-Bound Rab21 GTPase
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-21
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-01
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0F
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GDP-Bound Rab14 GTPase
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAB14, ...
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-01
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z2A
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GDP-Bound Rab23 GTPase crystallized in P2(1)2(1)2(1) space group
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-23
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-07
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZQ
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GppNHp-Bound Rab6 GTPase
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, small GTP binding protein RAB6 isoform
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-02-28
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZM
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Structure of Rabenosyn (458-503), Rab4 binding domain
分子名称: FYVE-finger-containing Rab5 effector protein rabenosyn-5
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-02-28
公開日2005-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z06
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GppNHp-Bound Rab33 GTPase
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-33B
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-01
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0D
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BU of 1z0d by Molmil
GDP-Bound Rab5c GTPase
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-03-01
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YVD
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GppNHp-Bound Rab22 GTPase
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-22A
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-02-15
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZT
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GppNHp-Bound Rab21 GTPase at 2.05 A Resolution
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-21
著者Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G.
登録日2005-02-28
公開日2005-07-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
5KCV
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Crystal structure of allosteric inhibitor, ARQ 092, in complex with autoinhibited form of AKT1
分子名称: 3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine, RAC-alpha serine/threonine-protein kinase
著者Eathiraj, S.
登録日2016-06-07
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor.
J.Med.Chem., 59, 2016

 

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