2XRE
 
 | | Detection of cobalt in previously unassigned human SENP1 structure | | Descriptor: | COBALT (II) ION, GLYCEROL, SENTRIN-SPECIFIC PROTEASE 1 | | Authors: | Rimsa, V, Eadsforth, T, Hay, R.T, Hunter, W.N. | | Deposit date: | 2010-09-14 | | Release date: | 2010-10-06 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | The Role of Co2+ in the Crystallization of Human Senp1 and Comments on the Limitations of Automated Refinement Protocols
Acta Crystallogr.,Sect.F, 67, 2011
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9SAM
 | | Crystal structure of SARS-CoV-2 NSP14 in complex with compound 26 | | Descriptor: | (1~{R},2~{S},3~{R},5~{S})-3-(6-aminopurin-9-yl)-5-(1,3-benzothiazol-2-ylsulfanylmethyl)cyclopentane-1,2-diol, Guanine-N7 methyltransferase nsp14, IMIDAZOLE, ... | | Authors: | Georgiou, I, Robinson, C, OByrne, S, Matsuda, A, Grygier, P, Smith, C, ONeill, S, Ahmad, S, Post, J, Groenewold, G.J.M, Urakova, N, Wanningen, P, Kresik, L, Plewka, J, Delpal, A, See, K, Eadsforth, T, Paul, M, Lis, K, Decroly, E, Singh Saikatendu, K, Chang, E, Snijder, E.J, Czarna, A, Pyrc, K, Scott, D, Gilbert, I. | | Deposit date: | 2025-08-07 | | Release date: | 2026-01-21 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase.
Rsc Med Chem, 2026
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9SAN
 | | Crystal structure of SARS-CoV-2 NSP14 in complex with compound 27 | | Descriptor: | (2~{R},3~{R},4~{S},5~{S})-2-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-(1,3-benzothiazol-2-ylsulfanylmethyl)oxolane-3,4-diol, 1,2-ETHANEDIOL, Guanine-N7 methyltransferase nsp14, ... | | Authors: | Georgiou, I, Robinson, C, OByrne, S, Matsuda, A, Grygier, P, Smith, C, ONeill, S, Ahmad, S, Post, J, Groenewold, G.J.M, Urakova, N, Wanningen, P, Kresik, L, Plewka, J, Delpal, A, See, K, Eadsforth, T, Paul, M, Lis, K, Decroly, E, Singh Saikatendu, K, Chang, E, Snijder, E.J, Czarna, A, Pyrc, K, Scott, D, Gilbert, I. | | Deposit date: | 2025-08-07 | | Release date: | 2026-01-21 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase.
Rsc Med Chem, 2026
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9SAK
 | | Crystal structure of SARS-CoV-2 NSP14 in complex with compound 6 | | Descriptor: | (2~{R},3~{R},4~{S},5~{S})-2-(6-aminopurin-9-yl)-5-(naphthalen-2-ylsulfanylmethyl)oxolane-3,4-diol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | Authors: | Georgiou, I, Robinson, C, OByrne, S, Matsuda, A, Grygier, P, Smith, C, ONeill, S, Ahmad, S, Post, J, Groenewold, G.J.M, Urakova, N, Wanningen, P, Kresik, L, Plewka, J, Delpal, A, See, K, Eadsforth, T, Paul, M, Lis, K, Decroly, E, Singh Saikatendu, K, Chang, E, Snijder, E.J, Czarna, A, Pyrc, K, Scott, D, Gilbert, I. | | Deposit date: | 2025-08-07 | | Release date: | 2026-01-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase.
Rsc Med Chem, 2026
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9S0M
 | | Crystal structure of SARS-CoV-2 NSP14 in complex with compound 1 | | Descriptor: | (2~{R},3~{R},4~{S},5~{S})-2-(6-aminopurin-9-yl)-5-(1,3-benzothiazol-2-ylsulfanylmethyl)oxolane-3,4-diol, Guanine-N7 methyltransferase nsp14, IMIDAZOLE, ... | | Authors: | Georgiou, I, Robinson, C, OByrne, S, Matsuda, A, Grygier, P, Smith, C, ONeill, S, Ahmad, S, Post, J, Groenewold, G.J.M, Urakova, N, Wanningen, P, Kresik, L, Plewka, J, Delpal, A, See, K, Eadsforth, T, Paul, M, Lis, K, Decroly, E, Singh Saikatendu, K, Chang, E, Snijder, E.J, Czarna, A, Pyrc, K, Scott, D, Gilbert, I. | | Deposit date: | 2025-07-16 | | Release date: | 2026-01-21 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase.
Rsc Med Chem, 2026
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9SAJ
 | | Crystal structure of SARS-CoV-2 NSP14 in complex with compound 5 | | Descriptor: | 1,2-ETHANEDIOL, 1-[2-[[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]ethyl]-3-ethyl-urea, CHLORIDE ION, ... | | Authors: | Georgiou, I, Robinson, C, OByrne, S, Matsuda, A, Grygier, P, Smith, C, ONeill, S, Ahmad, S, Post, J, Groenewold, G.J.M, Urakova, N, Wanningen, P, Kresik, L, Plewka, J, Delpal, A, See, K, Eadsforth, T, Paul, M, Lis, K, Decroly, E, Singh Saikatendu, K, Chang, E, Snijder, E.J, Czarna, A, Pyrc, K, Scott, D, Gilbert, I. | | Deposit date: | 2025-08-07 | | Release date: | 2026-01-21 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase.
Rsc Med Chem, 2026
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9SAL
 | | Crystal structure of SARS-CoV-2 NSP14 in complex with compound 18 | | Descriptor: | (2~{S},3~{S},4~{R},5~{R})-2-(1,3-benzothiazol-2-ylsulfanylmethyl)-5-[6-(methylamino)purin-9-yl]oxolane-3,4-diol, 1,2-ETHANEDIOL, Guanine-N7 methyltransferase nsp14, ... | | Authors: | Georgiou, I, Robinson, C, OByrne, S, Matsuda, A, Grygier, P, Smith, C, ONeill, S, Ahmad, S, Post, J, Groenewold, G.J.M, Urakova, N, Wanningen, P, Kresik, L, Plewka, J, Delpal, A, See, K, Eadsforth, T, Paul, M, Lis, K, Decroly, E, Singh Saikatendu, K, Chang, E, Snijder, E.J, Czarna, A, Pyrc, K, Scott, D, Gilbert, I. | | Deposit date: | 2025-08-07 | | Release date: | 2026-01-21 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase.
Rsc Med Chem, 2026
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2XPH
 | | Crystal structure of human SENP1 with the bound cobalt | | Descriptor: | COBALT (II) ION, GLYCEROL, SENTRIN-SPECIFIC PROTEASE 1 | | Authors: | Rimsa, V, Eadsforth, T, Hay, R.T, Hunter, W.N. | | Deposit date: | 2010-08-26 | | Release date: | 2010-09-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The Role of Co2+ in the Crystallization of Human Senp1 and Comments on the Limitations of Automated Refinement Protocols
Acta Crystallogr.,Sect.F, 67, 2011
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8Q69
 | | Crystal structure of HsRNMT complexed with inhibitor DDD1060606 | | Descriptor: | 1-[(3~{S})-3-(2~{H}-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl]-2-thiophen-3-yl-ethanone, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Petit, A.P, Fyfe, P.K. | | Deposit date: | 2023-08-11 | | Release date: | 2024-08-21 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach.
Biochem.J., 482, 2025
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8Q8G
 | | Crystal structure of HsRNMT complexed with inhibitor DDD1870799 | | Descriptor: | 2-(4-fluorophenyl)-1-[(3~{S})-3-(6-oxidanyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl]ethanone, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Petit, A.P, Fyfe, P.K. | | Deposit date: | 2023-08-18 | | Release date: | 2024-08-28 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach.
Biochem.J., 482, 2025
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8Q9W
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