4I28
| Binary complex of mouse TdT with ssDNA and Zn++ | 分子名称: | 5'-D(*AP*AP*AP*AP*A)-3', DNA nucleotidylexotransferase, MAGNESIUM ION, ... | 著者 | Gouge, J, Delarue, M. | 登録日 | 2012-11-21 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J.Mol.Biol., 425, 2013
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4IQT
| Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid | 分子名称: | 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid, DNA nucleotidylexotransferase | 著者 | Gouge, J, Delarue, M. | 登録日 | 2013-01-13 | 公開日 | 2013-09-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. J.Med.Chem., 56, 2013
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4IQU
| Tdt core in complex with inhibitor (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid | 分子名称: | (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid, DNA nucleotidylexotransferase, SODIUM ION | 著者 | Gouge, J, Delarue, M. | 登録日 | 2013-01-13 | 公開日 | 2013-09-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. J.Med.Chem., 56, 2013
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4IQV
| Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA | 分子名称: | 5'-D(*GP*CP*CP*G)-3', 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid, DNA nucleotidylexotransferase, ... | 著者 | Gouge, J, Delarue, M. | 登録日 | 2013-01-13 | 公開日 | 2013-09-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. J.Med.Chem., 56, 2013
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4IQW
| Tdt core in complex with inhibitor (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA | 分子名称: | (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid, 5'-D(*GP*CP*CP*G)-3', DNA nucleotidylexotransferase, ... | 著者 | Gouge, J, Delarue, M. | 登録日 | 2013-01-13 | 公開日 | 2013-09-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. J.Med.Chem., 56, 2013
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6FVR
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6FVS
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6FVQ
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6HJA
| Xray structure of GLIC in complex with glutarate | 分子名称: | CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECANE, ... | 著者 | Fourati, Z, Delarue, M. | 登録日 | 2018-09-03 | 公開日 | 2019-09-18 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel. Acta Crystallogr D Struct Biol, 76, 2020
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6HJ3
| Xray structure of GLIC in complex with fumarate | 分子名称: | CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Fourati, Z, Delarue, M. | 登録日 | 2018-08-31 | 公開日 | 2019-09-11 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel. Acta Crystallogr D Struct Biol, 76, 2020
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6HZ3
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6HYW
| THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y119F | 分子名称: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | 著者 | Hu, H.D, Delarue, M. | 登録日 | 2018-10-22 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HZ1
| THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243C | 分子名称: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | 著者 | Hu, H.D, Delarue, M. | 登録日 | 2018-10-22 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HZW
| THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL 2.22 resolution | 分子名称: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | 著者 | Hu, H.D, Delarue, M. | 登録日 | 2018-10-24 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HJI
| Xray structure of GLIC in complex with crotonate | 分子名称: | BUTENOIC ACID, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | 著者 | Fourati, Z, Delarue, M. | 登録日 | 2018-09-03 | 公開日 | 2019-09-18 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel. Acta Crystallogr D Struct Biol, 76, 2020
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6HPP
| X-ray structure of GLIC in complex with propionate | 分子名称: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, PROPANOIC ACID, ... | 著者 | Fourati, Z, Delarue, M. | 登録日 | 2018-09-21 | 公開日 | 2019-10-09 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel. Acta Crystallogr D Struct Biol, 76, 2020
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6HZ0
| THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT K248A | 分子名称: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | 著者 | Hu, H.D, Delarue, M. | 登録日 | 2018-10-22 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HY5
| THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193C | 分子名称: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | 著者 | Hu, H.D, Delarue, M. | 登録日 | 2018-10-19 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HYV
| THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y119A | 分子名称: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | 著者 | Hu, H.D, Delarue, M. | 登録日 | 2018-10-22 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HYX
| THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y197F-P250C | 分子名称: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Proton-gated ion channel, ... | 著者 | Hu, H.D, Delarue, M. | 登録日 | 2018-10-22 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HYR
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6HJB
| Xray structure of GLIC in complex with malonate | 分子名称: | CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Fourati, Z, Delarue, M. | 登録日 | 2018-09-03 | 公開日 | 2019-09-18 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel. Acta Crystallogr D Struct Biol, 76, 2020
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6HJZ
| Xray structure of GLIC in complex with succinate | 分子名称: | CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Fourati, Z, Delarue, M. | 登録日 | 2018-09-04 | 公開日 | 2019-09-18 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel. Acta Crystallogr D Struct Biol, 76, 2020
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6HYA
| THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193L | 分子名称: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Proton-gated ion channel | 著者 | Hu, H.D, Delarue, M. | 登録日 | 2018-10-19 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3.39 Å) | 主引用文献 | Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HYZ
| THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT K248C | 分子名称: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | 著者 | Hu, H.D, Delarue, M. | 登録日 | 2018-10-22 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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