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Crystal structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with cytidine and FOL955, 4-(1H-imidazol)-1-yl)phenol
Descriptor:	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 4-(1H-IMIDAZOL-1-YL)PHENOL, 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2010-09-29
Release date:	2010-10-20
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. J Struct Funct Genomics, 12, 2011

4DLP

Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis bound to selenomethionine
Descriptor:	Aminoacyl-tRNA synthetase, class I:Aminoacyl-tRNA synthetase, class Ia:Methionyl-tRNA synthetase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-02-06
Release date:	2012-02-15
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. Plos One, 11, 2016

7MFC

Crystal structure of CSF1R in complex with vimseltinib
Descriptor:	Macrophage colony-stimulating factor 1 receptor, Vimseltinib
Authors:	Abendroth, J, Davies, D.R, Atkins, K.
Deposit date:	2021-04-08
Release date:	2021-11-24
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages. Mol.Cancer Ther., 20, 2021

4DZ6

Transition state mimic of nucleoside-diphosphate kinase from borrelia burgdorferi with bound vanadate and adp
Descriptor:	1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-02-29
Release date:	2012-03-14
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structure and analysis of nucleoside diphosphate kinase from Borrelia burgdorferi prepared in a transition-state complex with ADP and vanadate moieties. Acta Crystallogr F Struct Biol Commun, 74, 2018

4DI6

crystal structure of nucleoside-diphosphate kinase from Borrelia burgdorferi
Descriptor:	Nucleoside diphosphate kinase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-01-30
Release date:	2012-02-08
Last modified:	2018-06-13
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Structure and analysis of nucleoside diphosphate kinase from Borrelia burgdorferi prepared in a transition-state complex with ADP and vanadate moieties. Acta Crystallogr F Struct Biol Commun, 74, 2018

3QHD

Crystal structure of 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE Synthase from BURKHOLDERIA PSEUDOMALLEI bound to CYTIDINE, FOL795 and FOL955
Descriptor:	2-(pyridin-3-yl)-1,3-thiazole-4-carbaldehyde, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 4-(1H-IMIDAZOL-1-YL)PHENOL, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-01-25
Release date:	2011-02-09
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. J Struct Funct Genomics, 12, 2011

5HAL

Crystal Structure of a putative beta-lactamase from Burkholderia vietnamiensis
Descriptor:	1,2-ETHANEDIOL, Uncharacterized protein
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-12-30
Release date:	2016-01-13
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.1507 Å)
Cite:	Crystal Structure of a putative beta-lactamase from Burkholderia vietnamiensis to be published

3RQI

Crystal structure of a response regulator protein from Burkholderia pseudomallei with a phosphorylated aspartic acid, calcium ion and citrate
Descriptor:	CALCIUM ION, CITRIC ACID, GLYCEROL, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-04-28
Release date:	2011-05-11
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Crystal structure of a response regulator protein from Burkholderia pseudomallei with a phosphorylated aspartic acid, calcium ion and citrate To be Published

5IEQ

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-747 1-(4-chlorophenyl)-1H-imidazole
Descriptor:	1-(4-CHLOROPHENYL)-1H-IMIDAZOLE, DIMETHYL SULFOXIDE, Polymerase acidic protein
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-02-25
Release date:	2017-02-22
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published

5IF2

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-576 (5,6-dichloro-1H-1,3-benzodiazol-2-yl)methanol
Descriptor:	(5,6-dichloro-1H-benzimidazol-2-yl)methanol, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-02-25
Release date:	2017-02-22
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published

5IFD

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4721 1-(4-fluorophenyl)-1H-imidazole
Descriptor:	1-(4-fluorophenyl)-1H-imidazole, DIMETHYL SULFOXIDE, Polymerase acidic protein
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-02-25
Release date:	2017-02-22
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published

4F2N

Crystal structure of iron superoxide dismutase from Leishmania major
Descriptor:	FE (II) ION, Superoxide dismutase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-05-08
Release date:	2012-05-16
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures. Acta Crystallogr F Struct Biol Commun, 71, 2015

4F82

X-ray crystal structure of a putative thioredoxin reductase from Burkholderia cenocepacia
Descriptor:	Thioredoxin Reductase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-05-16
Release date:	2012-06-27
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	X-ray crystal structure of a putative thioredoxin reductase from Burkholderia cenocepacia TO BE PUBLISHED

5IF5

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to EBSI-39 (2,3-dichlorophenyl)methanol
Descriptor:	(2,3-dichlorophenyl)methanol, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-02-25
Release date:	2017-03-08
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published

5IFC

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4720 1-(4-bromophenyl)-1H-imidazole
Descriptor:	1-(4-bromophenyl)-1H-imidazole, DIMETHYL SULFOXIDE, Polymerase acidic protein
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-02-25
Release date:	2017-02-22
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published

5IF8

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-2643 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine
Descriptor:	1,2-ETHANEDIOL, 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-02-25
Release date:	2017-02-22
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published

5IF7

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Descriptor:	DIMETHYL SULFOXIDE, N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Polymerase acidic protein
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-02-25
Release date:	2017-02-22
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published

4G6C

Crystal structure of beta-hexosaminidase 1 from Burkholderia cenocepacia J2315
Descriptor:	Beta-hexosaminidase 1
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-07-18
Release date:	2012-08-01
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.38 Å)
Cite:	Crystal structure of beta-hexosaminidase 1 from Burkholderia cenocepacia J2315 To be Published

7S5M

Crystal Structure of a 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase from Mycobacterium smegmatis
Descriptor:	8-amino-7-oxononanoate synthase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-09-10
Release date:	2021-09-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Crystal Structure of a 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase from Mycobacterium smegmatis to be published

7SY9

Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1
Descriptor:	ACETATE ION, FORMIC ACID, UDP-N-acetylmuramoylalanine--D-glutamate ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-11-24
Release date:	2021-12-15
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 to be published

7T7J

Crystal Structure of Phosphoserine aminotransferase from Klebsiella pneumoniae subsp. pneumoniae in complex with Pyridoxal phosphate
Descriptor:	PYRIDOXAL-5'-PHOSPHATE, Phosphoserine aminotransferase
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-15
Release date:	2022-01-12
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Crystal Structure of Phosphoserine aminotransferase from Klebsiella pneumoniae subsp. pneumoniae in complex with Pyridoxal phosphate to be published

7K86

Crystal Structure of Glutamyl-tRNA synthetase (gltX) from Stenotrophomonas maltophilia
Descriptor:	1,2-ETHANEDIOL, ACETATE ION, Glutamate--tRNA ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-09-25
Release date:	2020-10-07
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Crystal Structure of Glutamyl-tRNA synthetase (gltX) from Stenotrophomonas maltophilia to be published

7L9R

Crystal Structure of a putative deoxyhypusine synthase from Entamoeba histolytica
Descriptor:	CHLORIDE ION, Deoxyhypusine synthase, putative
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-01-04
Release date:	2021-02-10
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystal Structure of a putative deoxyhypusine synthase from Entamoeba histolytica to be published

6BKW

BTK complex with compound 12
Descriptor:	GLYCEROL, N-(3-{5-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide, SULFATE ION, ...
Authors:	Kiefer, J.R, Eigenbrot, C, Yu, C.L.
Deposit date:	2017-11-09
Release date:	2018-11-07
Last modified:	2019-03-27
Method:	X-RAY DIFFRACTION (1.499 Å)
Cite:	Water molecules in protein-ligand interfaces. Evaluation of software tools and SAR comparison. J. Comput. Aided Mol. Des., 33, 2019

6BQA

BRD9 bromodomain in complex with 3-(6-(but-3-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethylbenzamide
Descriptor:	3-[6-(but-3-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl]-N,N-dimethylbenzamide, Bromodomain-containing protein 9
Authors:	Murray, J.M, Tang, Y.
Deposit date:	2017-11-27
Release date:	2018-11-14
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.031 Å)
Cite:	Water molecules in protein-ligand interfaces. Evaluation of software tools and SAR comparison. J. Comput. Aided Mol. Des., 33, 2019

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