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C-term tail segment of human tyrosine kinase (258-533)
Descriptor:	Proto-oncogene tyrosine-protein kinase Src
Authors:	Fleury, D, Sarubbi, E, Courjaud, A, Guitton, J.D, Ducruix, A.
Deposit date:	2005-01-11
Release date:	2006-05-02
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structure of the unphosphorylated C-terminal tail segment of the SRC kinase and its role in SRC activity regulation To be published

Estrogen receptor mutant L536S
Descriptor:	6-(2,4-dichlorophenyl)-5-[4-[(3~{S})-1-(3-fluoranylpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7~{H}-benzo[7]annulene-2-carboxylic acid, Estrogen receptor
Authors:	Vallee, F, Steier, V, Rak, A.
Deposit date:	2019-07-22
Release date:	2019-11-27
Last modified:	2024-05-15
Method:	X-RAY DIFFRACTION (1.48 Å)
Cite:	Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer. J.Med.Chem., 63, 2020