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1DTJ
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BU of 1dtj by Molmil
CRYSTAL STRUCTURE OF NOVA-2 KH3 K-HOMOLOGY RNA-BINDING DOMAIN
Descriptor: RNA-BINDING NEUROONCOLOGICAL VENTRAL ANTIGEN 2
Authors:Lewis, H.A, Chen, H, Edo, C, Buckanovich, R.J, Yang, Y.Y.L, Musunuru, K, Zhong, R, Darnell, R.B, Burley, S.K.
Deposit date:2000-01-12
Release date:2000-02-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains.
Structure Fold.Des., 7, 1999
1DT4
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BU of 1dt4 by Molmil
CRYSTAL STRUCTURE OF NOVA-1 KH3 K-HOMOLOGY RNA-BINDING DOMAIN
Descriptor: NEURO-ONCOLOGICAL VENTRAL ANTIGEN 1
Authors:Lewis, H.A, Chen, H, Edo, C, Buckanovich, R.J, Yang, Y.Y.L.
Deposit date:2000-01-11
Release date:2000-02-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains.
Structure Fold.Des., 7, 1999
6DUM
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BU of 6dum by Molmil
ALDH1A1 N121S in complex with 6-{[(3-fluorophenyl)methyl]sulfanyl}-2-(oxetan-3-yl)-5-phenyl-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (compound 13g)
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 6-{[(3-fluorophenyl)methyl]sulfanyl}-2-(oxetan-3-yl)-5-phenyl-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, CHLORIDE ION, ...
Authors:Buchman, C.D, Hurley, T.D.
Deposit date:2018-06-21
Release date:2019-05-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
J.Med.Chem., 61, 2018
8T0N
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BU of 8t0n by Molmil
Structure of Compound 4 bound to human ALDH1A1
Descriptor: 2-methoxy-6-{[(1-propyl-1H-benzimidazol-2-yl)amino]methyl}phenol, Aldehyde dehydrogenase 1A1, CHLORIDE ION, ...
Authors:Hurley, T.D.
Deposit date:2023-06-01
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes.
Chem.Biol.Interact., 391, 2024
8T0T
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BU of 8t0t by Molmil
Structure of Compound 4 bound to human ALDH1A1
Descriptor: 1-(4-{6-fluoro-3-[4-(methanesulfonyl)piperazine-1-carbonyl]quinolin-4-yl}phenyl)cyclopropane-1-carbonitrile, Aldehyde dehydrogenase 1A1, CHLORIDE ION, ...
Authors:Hurley, T.D.
Deposit date:2023-06-01
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes.
Chem.Biol.Interact., 391, 2024
7JWV
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BU of 7jwv by Molmil
Crystal structure of human ALDH1A1 bound to compound (R)-28
Descriptor: 5-[4-(hydroxymethyl)phenyl]-1-methyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, CHLORIDE ION, Retinal dehydrogenase 1, ...
Authors:Hurley, T.D, Buchman, C.
Deposit date:2020-08-26
Release date:2020-12-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Eur.J.Med.Chem., 211, 2020
7JWS
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BU of 7jws by Molmil
Crystal structure of human ALDH1A1 bound to compound (R)-28
Descriptor: 1-methyl-5-phenyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, CHLORIDE ION, Retinal dehydrogenase 1, ...
Authors:Hurley, T.D, Buchman, C.
Deposit date:2020-08-26
Release date:2020-12-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Eur.J.Med.Chem., 211, 2020
7JWU
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BU of 7jwu by Molmil
Crystal structure of human ALDH1A1 bound to compound (R)-28
Descriptor: 1-methyl-5-phenyl-6-{[(1R)-1-(pyridin-2-yl)ethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Hurley, T.D, Buchman, C.
Deposit date:2020-08-26
Release date:2020-12-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Eur.J.Med.Chem., 211, 2020
7JWW
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BU of 7jww by Molmil
Crystal structure of human ALDH1A1 bound to compound (R)-28
Descriptor: 5-{4-[(Z)-2-hydroxyethenyl]phenyl}-1-methyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, CHLORIDE ION, Retinal dehydrogenase 1, ...
Authors:Hurley, T.D, Buchman, C.
Deposit date:2020-08-26
Release date:2020-12-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Eur.J.Med.Chem., 211, 2020
7JWT
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BU of 7jwt by Molmil
Crystal structure of human ALDH1A1 bound to compound (R)-28
Descriptor: 6-{[(1R)-1-(3-hydroxyphenyl)ethyl]sulfanyl}-1-methyl-5-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, CHLORIDE ION, Retinal dehydrogenase 1, ...
Authors:Hurley, T.D, Buchman, C.
Deposit date:2020-08-26
Release date:2020-12-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Eur.J.Med.Chem., 211, 2020

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PDB entries from 2024-10-30

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