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Menin bound to M-89
Descriptor:	(1S,2R)-2-[(4S)-2-methyl-4-{1-[(1-{4-[(pyridin-4-yl)sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}-1,2,3,4-tetrahydroisoquinolin-4-yl]cyclopentyl methylcarbamate, Menin, praseodymium triacetate
Authors:	Stuckey, J.A.
Deposit date:	2018-07-09
Release date:	2019-07-10
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J.Med.Chem., 62, 2019

DCN1 bound to DI-591
Descriptor:	DCN1-like protein 1, N-[(1S)-1-cyclohexyl-2-{[3-(morpholin-4-yl)propanoyl]amino}ethyl]-N~2~-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alaninamide
Authors:	Stuckey, J.
Deposit date:	2017-01-04
Release date:	2017-11-01
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.58 Å)
Cite:	A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation. Nat Commun, 8, 2017