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Crystal structure of the topoisomerase VI holoenzyme from Methanosarcina mazei
Descriptor:	Type 2 DNA topoisomerase 6 subunit B, Type II DNA topoisomerase VI subunit A
Authors:	Corbett, K.D, Benedetti, P, Berger, J.M.
Deposit date:	2007-05-28
Release date:	2007-07-10
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (4 Å)
Cite:	Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI Nat.Struct.Mol.Biol., 14, 2007

Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor
Descriptor:	2-{(2Z,5S)-4-hydroxy-2-[(2E)-(2-hydroxybenzylidene)hydrazinylidene]-2,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, 2-{(5S)-2-[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, SULFATE ION, ...
Authors:	Tochowicz, A, Finer-Moore, J, Stroud, R.M, Costi, M.P.
Deposit date:	2012-03-07
Release date:	2012-11-14
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.302 Å)
Cite:	Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. J.Med.Chem., 55, 2012