9HJV
 
 | | Crystal structure of flavin-dependent monooxygenase Tet(X4) in complex with prochlorperazine | | Descriptor: | 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent monooxygenase, ... | | Authors: | Beech, M.J, Smith, H.G, Allen, M.D, Farley, A.J.M, Schofield, C.J. | | Deposit date: | 2024-12-02 | | Release date: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance.
Chem Sci, 2025
|
|
9HKE
 | | Crystal structure of flavin-dependent monooxygenase Tet(X4) in complex with trifluoperazine | | Descriptor: | 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent monooxygenase, ... | | Authors: | Smith, H.G, Beech, M.J, Allen, M.D, Farley, A.J.M, Schofield, C.J. | | Deposit date: | 2024-12-03 | | Release date: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance.
Chem Sci, 2025
|
|
9HJW
 | | Crystal structure of flavin-dependent monooxygenase Tet(X4) in complex with tegaserod | | Descriptor: | 1-[(~{E})-(5-methoxy-1~{H}-indol-3-yl)methylideneamino]-3-pentyl-guanidine, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent monooxygenase, ... | | Authors: | Smith, H.G, Beech, M.J, Allen, M.D, Farley, A.J.M, Schofield, C.J. | | Deposit date: | 2024-12-02 | | Release date: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance.
Chem Sci, 2025
|
|
9FZE
 | | Pseudomonas aeruginosa penicillin binding protein 3 in complex with meropenem | | Descriptor: | (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Peptidoglycan D,D-transpeptidase FtsI | | Authors: | Smith, H.G, Allen, M.D, Basak, S, Aniebok, V, Beech, M.J, Alshref, F.M, Farley, A.J.M, Schofield, C.J. | | Deposit date: | 2024-07-05 | | Release date: | 2024-10-09 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis of Pseudomonas aeruginosa penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol.
Chem Sci, 15, 2024
|
|
9FZP
 | | Pseudomonas aeruginosa penicillin binding protein 3 in complex with cefepime | | Descriptor: | CEFOTAXIME, C3' cleaved, open, ... | | Authors: | Smith, H.G, Allen, M.D, Basak, S, Aniebok, V, Beech, M.J, Alshref, F.M, Farley, A.J.M, Schofield, C.J. | | Deposit date: | 2024-07-05 | | Release date: | 2024-10-09 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis of Pseudomonas aeruginosa penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol.
Chem Sci, 15, 2024
|
|
9FZ7
 | | Pseudomonas aeruginosa penicillin binding protein 3 in complex with cefiderocol | | Descriptor: | ACYLATED CEFTAZIDIME, Peptidoglycan D,D-transpeptidase FtsI | | Authors: | Smith, H.G, Allen, M.D, Basak, S, Aniebok, V, Beech, M.J, Alshref, F.M, Farley, A.J.M, Schofield, C.J. | | Deposit date: | 2024-07-04 | | Release date: | 2024-10-09 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis of Pseudomonas aeruginosa penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol.
Chem Sci, 15, 2024
|
|
9FZO
 | | Pseudomonas aeruginosa penicillin binding protein 3 in complex with ceftazidime | | Descriptor: | ACYLATED CEFTAZIDIME, Peptidoglycan D,D-transpeptidase FtsI, SULFATE ION | | Authors: | Smith, H.G, Allen, M.D, Basak, S, Aniebok, V, Beech, M.J, Alshref, F.M, Farley, A.J.M, Schofield, C.J. | | Deposit date: | 2024-07-05 | | Release date: | 2024-10-09 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis of Pseudomonas aeruginosa penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol.
Chem Sci, 15, 2024
|
|
9FZ8
 | | Pseudomonas aeruginosa penicillin binding protein 3 | | Descriptor: | Peptidoglycan D,D-transpeptidase FtsI | | Authors: | Smith, H.G, Allen, M.D, Basak, S, Aniebok, V, Beech, M.J, Alshref, F.M, Farley, A.J.M, Schofield, C.J. | | Deposit date: | 2024-07-04 | | Release date: | 2024-10-09 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Structural basis of Pseudomonas aeruginosa penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol.
Chem Sci, 15, 2024
|
|
8AQR
 | |
8AQQ
 | |
