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8IPL
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BU of 8ipl by Molmil
The structure of human mitochondrial methyltransferase METTL15 with RBFA and SAM
Descriptor: 12S rRNA N4-methylcytidine (m4C) methyltransferase, Putative ribosome-binding factor A, mitochondrial, ...
Authors:Lv, M.Q, Zhou, W.W.
Deposit date:2023-03-14
Release date:2024-01-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.
Cell Discov, 10, 2024
8IPM
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BU of 8ipm by Molmil
The structure of human mitochondrial methyltransferase METTL15 with h44_RNA, RBFA and SAM
Descriptor: 12S rRNA N4-methylcytidine (m4C) methyltransferase, Putative ribosome-binding factor A, mitochondrial, ...
Authors:Lv, M.Q, Zhou, W.W.
Deposit date:2023-03-14
Release date:2024-01-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.
Cell Discov, 10, 2024
8IPK
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BU of 8ipk by Molmil
The structure of human mitochondrial methyltransferase METTL15 with SAM
Descriptor: 12S rRNA N4-methylcytidine (m4C) methyltransferase, GLYCEROL, S-ADENOSYLMETHIONINE
Authors:Lv, M.Q, Zhou, W.W.
Deposit date:2023-03-14
Release date:2024-01-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.
Cell Discov, 10, 2024
7YF2
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BU of 7yf2 by Molmil
Crystal structure of METTL9 in complex with unmethylated SLC39A5 peptide and SAH
Descriptor: Protein-L-histidine N-pros-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, SLC39A5 peptide
Authors:Xie, H, Wang, X, Xu, C.
Deposit date:2022-07-07
Release date:2023-04-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.691 Å)
Cite:Molecular basis for METTL9-mediated N1-histidine methylation.
Cell Discov, 9, 2023
7YF3
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BU of 7yf3 by Molmil
Crystal structure of METTL9 in complex with unmethylated S100A9 peptide and SAH
Descriptor: Protein-L-histidine N-pros-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, S100A9 peptide
Authors:Xie, H, Wang, X, Xu, C.
Deposit date:2022-07-07
Release date:2023-04-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.434 Å)
Cite:Molecular basis for METTL9-mediated N1-histidine methylation.
Cell Discov, 9, 2023
7Y9C
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BU of 7y9c by Molmil
Crystal structure of METTL9 in complex with SLC39A5 peptide and SAH
Descriptor: Protein-L-histidine N-pros-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, SLC39A5
Authors:Xie, H, Wang, X, Xu, C.
Deposit date:2022-06-24
Release date:2023-04-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular basis for METTL9-mediated N1-histidine methylation.
Cell Discov, 9, 2023
7YF4
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BU of 7yf4 by Molmil
Crystal structure of METTL9 in complex with SLC39A5 mutant peptide and SAH
Descriptor: Protein-L-histidine N-pros-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, SLC39A5 mutant peptide
Authors:Xie, H, Wang, X, Xu, C.
Deposit date:2022-07-07
Release date:2023-04-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular basis for METTL9-mediated N1-histidine methylation.
Cell Discov, 9, 2023
7E74
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BU of 7e74 by Molmil
Crystal structure of ENL YEATS domain T3 mutant in complex with histone H3 acetylation at K27
Descriptor: ALA-ALA-ARG-ALY, Protein ENL
Authors:Li, Y, Li, H.
Deposit date:2021-02-25
Release date:2021-07-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Mol.Cell, 82, 2022
7TYU
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BU of 7tyu by Molmil
TEAD2 bound to Compound 2
Descriptor: (3R)-1-[(8S)-5-(4-cyclohexylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonyl]pyrrolidine-3-carbonitrile, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcriptional enhancer factor TEF-4
Authors:Noland, C.L, Fong, R.
Deposit date:2022-02-14
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an expanded Hippo dependent landscape in cancers
To Be Published
7TYQ
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BU of 7tyq by Molmil
TEAD2 bound to Compound 1
Descriptor: Transcriptional enhancer factor TEF-4, ethyl (8S)-7-oxo-5-[4-(trifluoromethyl)phenyl]-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate
Authors:Noland, C.L, Fong, R.
Deposit date:2022-02-14
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an expanded Hippo dependent landscape in cancers
To Be Published
7TYP
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BU of 7typ by Molmil
TEAD2 bound to GNE-7883
Descriptor: (8S)-5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcriptional enhancer factor TEF-4
Authors:Noland, C.L, Fong, R.
Deposit date:2022-02-14
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an expanded Hippo dependent landscape in cancers
To Be Published
7XDT
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BU of 7xdt by Molmil
Structural basis for Gemin5 decamer-mediated mRNA binding
Descriptor: Gem-associated protein 5
Authors:Guo, Q, Zhao, S, Zhang, K, Xu, C.
Deposit date:2022-03-28
Release date:2022-08-24
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Structural basis for Gemin5 decamer-mediated mRNA binding.
Nat Commun, 13, 2022
7XGR
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BU of 7xgr by Molmil
Structure of Gemin5 C-terminal region (protomer)
Descriptor: Gem-associated protein 5
Authors:Guo, Q, Zhao, S, Zhang, K, Xu, C.
Deposit date:2022-04-06
Release date:2022-08-24
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for Gemin5 decamer-mediated mRNA binding.
Nat Commun, 13, 2022
7X8G
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BU of 7x8g by Molmil
Crystal structure of ENL T1(H116P) mutant YEATS domain in complex with histone H3 acetylation at K27
Descriptor: H3K27ac(24-27) peptide, Protein ENL
Authors:Li, Y, Peng, B, Li, H.
Deposit date:2022-03-12
Release date:2023-01-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Mol.Cell, 82, 2022
7X8F
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BU of 7x8f by Molmil
Crystal structure of ENL T4 mutant YEATS domain in complex with histone H3 acetylation at K27
Descriptor: CHLORIDE ION, H3K27ac(24-27) peptide, Protein ENL
Authors:Li, Y, Peng, B, Li, H.
Deposit date:2022-03-12
Release date:2023-01-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Mol.Cell, 82, 2022
7X8B
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BU of 7x8b by Molmil
Crystal structure of ENL T1 mutant YEATS domain in complex with histone H3 acetylation at K27
Descriptor: H3K27ac(24-27) peptide, Protein ENL
Authors:Li, Y, Peng, B, Li, H.
Deposit date:2022-03-11
Release date:2023-01-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Mol.Cell, 82, 2022
7X88
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BU of 7x88 by Molmil
Crystal structure of ENL YEATS domain T2 mutant in complex with histone H3 acetylation at K27
Descriptor: CITRIC ACID, Histone H3K27ac(24-27) peptide, Protein ENL
Authors:Li, Y.Y, Li, H.T.
Deposit date:2022-03-11
Release date:2023-01-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Mol.Cell, 82, 2022

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數據於2024-05-22公開中

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