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Crystal structure of Mtb aspartate decarboxylase, pyrazinoic acid complex
Descriptor:	Aspartate 1-decarboxylase alpha chain, Aspartate 1-decarboxylase beta chain, PYRAZINE-2-CARBOXYLIC ACID
Authors:	Sun, Q, Li, X, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:	2019-05-15
Release date:	2020-02-05
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD. Nat Commun, 11, 2020

6P02

Crystal structure of Mtb aspartate decarboxylase, 6-Chlorine pyrazinoic acid complex
Descriptor:	6-chloropyrazine-2-carboxylic acid, Aspartate 1-decarboxylase alpha chain, Aspartate 1-decarboxylase beta chain
Authors:	Sun, Q, Li, X, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:	2019-05-16
Release date:	2020-02-05
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD. Nat Commun, 11, 2020

6OZ8

Crystal structure of Mtb aspartate decarboxylase in active form
Descriptor:	Aspartate 1 decarboxylase alpha chain, Aspartate 1 decarboxylase beta chain
Authors:	Sun, Q, Li, X, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:	2019-05-15
Release date:	2020-02-05
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD. Nat Commun, 11, 2020

6P1Y

Crystal structure of Mtb aspartate decarboxylase mutant M117I
Descriptor:	AMMONIUM ION, Aspartate 1-decarboxylase alpha chain, Aspartate 1-decarboxylase beta chain, ...
Authors:	Sun, Q, Li, X, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:	2019-05-20
Release date:	2020-02-05
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.33 Å)
Cite:	The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD. Nat Commun, 11, 2020

6PSH

Crystal structure of periplasmic domain of antiholin RI from T4 phage
Descriptor:	1,2-ETHANEDIOL, Antiholin
Authors:	Kuznetsov, V.B, Krieger, I.V, Sacchettini, J.C.
Deposit date:	2019-07-12
Release date:	2020-06-24
Last modified:	2020-08-12
Method:	X-RAY DIFFRACTION (2.21 Å)
Cite:	The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition. J.Mol.Biol., 432, 2020

6PXE

Crystal structure of the complex between periplasmic domains of antiholin RI and holin T from T4 phage, in P21
Descriptor:	Antiholin, Holin
Authors:	Krieger, I.V, Sacchettini, J.C.
Deposit date:	2019-07-25
Release date:	2020-06-24
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition. J.Mol.Biol., 432, 2020

6PSK

Crystal structure of the complex between periplasmic domains of antiholin RI and holin T from T4 phage, in P6522
Descriptor:	1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Antiholin, ...
Authors:	Kuznetsov, V.B, Krieger, I.V, Sacchettini, J.C.
Deposit date:	2019-07-12
Release date:	2020-06-24
Last modified:	2020-08-12
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition. J.Mol.Biol., 432, 2020

6PX4

Crystal structure of the complex between periplasmic domains of antiholin RI and holin T from T4 phage, in H32
Descriptor:	Antiholin, Holin
Authors:	Krieger, I.V, Sacchettini, J.C.
Deposit date:	2019-07-24
Release date:	2020-06-24
Last modified:	2020-08-12
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition. J.Mol.Biol., 432, 2020

5C7V

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-pyrrole-2-carboxylic acid
Descriptor:	MAGNESIUM ION, Malate synthase G, PYRROLE-2-CARBOXYLATE
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-06-25
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.504 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5CAH

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 6H-thieno[2,3-b]pyrrole-5-carboxylic acid
Descriptor:	6H-thieno[2,3-b]pyrrole-5-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-06-29
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.303 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5CC5

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-indole-3-carboxylic acid
Descriptor:	1H-INDOLE-3-CARBOXYLIC ACID, GLYOXYLIC ACID, MAGNESIUM ION, ...
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-07-01
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.14 Å)
Cite:	Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs To Be Published

5C9X

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2,4-dichloro-5-fluorobenzoic acid
Descriptor:	2,4-dichloro-5-fluorobenzoic acid, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-06-29
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5CBB

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 5-(3H-indol-3-ylidene)-2,5-dihydro-1H-pyrazole-3-carboxylate
Descriptor:	(5E)-5-(3H-indol-3-ylidene)-2,5-dihydro-1H-pyrazole-3-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-06-30
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.012 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5CJN

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 3-(3-oxo-3,4-dihydroquinoxalin-2-yl)acrylate
Descriptor:	3-(3-oxo-3,4-dihydroquinoxalin-2-yl)propanoic acid, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-07-14
Release date:	2016-08-10
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.19 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5C9U

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-(2-(2,4-dichlorophenyl)hydrazinyl)-2-oxoacetic acid
Descriptor:	MAGNESIUM ION, Malate synthase G, [2-(2,4-dichlorophenyl)hydrazinyl](oxo)acetic acid
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-06-29
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5CBI

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 5-chloro-2-hydroxybenzonitrile
Descriptor:	5-chloro-2-hydroxybenzonitrile, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-06-30
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.988 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5CC6

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-indole-5-carboxylic acid
Descriptor:	1H-indole-5-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-07-01
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs To Be Published

5CJM

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4H-thieno[3,2-b]pyrrole-5-carboxylic acid
Descriptor:	4H-THIENO[3,2-B]PYROLE-5-CARBOXYLIC ACID, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-07-14
Release date:	2016-08-10
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.13 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5CC3

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 6-bromo-1H-indole-2-carboxylic acid
Descriptor:	6-bromanyl-1H-indole-2-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-07-01
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.204 Å)
Cite:	Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs To Be Published

5C9W

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with (Z)-N-(2-bromophenyl)-2-(hydroxyimino)acetamide
Descriptor:	(2E)-N-(2-bromophenyl)-2-(hydroxyimino)acetamide, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-06-29
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.0928 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5CC7

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-indole-6-carboxylic acid
Descriptor:	1H-indole-6-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-07-01
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.12 Å)
Cite:	Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs To Be Published

5CEW

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-(pyridin-4-yl)thiazolidine-4-carboxylic acid
Descriptor:	(2S,4S)-2-(pyridin-4-yl)-1,3-thiazolidine-4-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-07-07
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.03 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5CBJ

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 3-(phenylthio)acrylic acid
Descriptor:	(2E)-3-(phenylsulfanyl)prop-2-enoic acid, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-06-30
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.957 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5CCZ

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 3-(4-fluorophenyl)-4-methyl-1H-pyrazol-5-amine
Descriptor:	3-(4-fluorophenyl)-4-methyl-1H-pyrazol-5-amine, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-07-02
Release date:	2016-08-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.136 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

5C9R

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 3-((4-chlorophenyl)thio)propanoic acid
Descriptor:	3-[(4-chlorophenyl)sulfanyl]propanoic acid, MAGNESIUM ION, Malate synthase G
Authors:	Huang, H.-L, Sacchettini, J.C.
Deposit date:	2015-06-28
Release date:	2016-07-27
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016

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