7FGQ
 
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7VEP
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6KDU
 | | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | | 分子名称: | ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... | | 著者 | Ramachandran, R, Shukla, A, Afsar, M. | | 登録日 | 2019-07-02 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
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6KJM
 | | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | | 分子名称: | ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... | | 著者 | Ramachandran, R, Shukla, A, Afsar, M. | | 登録日 | 2019-07-22 | | 公開日 | 2020-07-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A.
J.Struct.Biol., 213, 2021
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6KKV
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6KRH
 | | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | | 分子名称: | ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... | | 著者 | Ramachandran, R, Shukla, A, Afsar, M. | | 登録日 | 2019-08-21 | | 公開日 | 2020-08-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
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6KSC
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6KSD
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6LW8
 | | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | | 分子名称: | (4R)-4-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, DNA ligase A, GLYCEROL, ... | | 著者 | Ramachandran, R, Afsar, M, Shukla, A. | | 登録日 | 2020-02-07 | | 公開日 | 2021-02-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | | 主引用文献 | Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A.
J.Struct.Biol., 213, 2021
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5T41
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5IS2
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5IT4
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5IT0
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5JLR
 | | Crystal structure of Mycobacterium avium SerB2 with serine present at slightly different position near ACT domain | | 分子名称: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, MAGNESIUM ION, ... | | 著者 | Shree, S, Agrawal, A, Dubey, S, Ramachandran, R. | | 登録日 | 2016-04-27 | | 公開日 | 2017-05-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.261 Å) | | 主引用文献 | Crystal structure of Mycobacterium avium SerB2 with serine present at slightly different position near ACT domain
To be published
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5JJB
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5JMA
 | | Crystal structure of Mycobacterium avium SerB2 in complex with serine at catalytic (PSP) domain | | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, Phosphoserine phosphatase, ... | | 著者 | Shree, S, Dubey, S, Agrawal, A, Ramachandran, R. | | 登録日 | 2016-04-28 | | 公開日 | 2017-05-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Crystal structure of Mycobacterium avium SerB2 in complex with serine at catalytic (PSP) domain
To be published
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5JLP
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1Z30
 | | NMR structure of the apical part of stemloop D from cloverleaf 1 of bovine enterovirus 1 RNA | | 分子名称: | 5'-R(*GP*GP*CP*GP*UP*UP*CP*GP*UP*UP*AP*GP*AP*AP*CP*GP*UP*C)-3' | | 著者 | Ihle, Y, Ohlenschlager, O, Duchardt, E, Ramachandran, R, Gorlach, M. | | 登録日 | 2005-03-10 | | 公開日 | 2005-04-26 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNA
Nucleic Acids Res., 33, 2005
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3RB9
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3S5C
 | | Crystal Structure of a Hexachlorocyclohexane dehydrochlorinase (LinA) Type2 | | 分子名称: | LinA | | 著者 | Kukshal, V, Macwan, A.S, Kumar, A, Ramachandran, R. | | 登録日 | 2011-05-23 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystal structure of the hexachlorocyclohexane dehydrochlorinase (LinA-type2): mutational analysis, thermostability and enantioselectivity
Plos One, 7, 2012
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4PCQ
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2VC0
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2VBY
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2VBX
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2VBW
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