3EQB
| X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... | 著者 | Ohren, J.F, Pavlovsky, A, Zhang, E. | 登録日 | 2008-09-30 | 公開日 | 2008-11-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase). Bioorg.Med.Chem.Lett., 18, 2008
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1GDJ
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1GDK
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1GDI
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1GDL
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3KEK
| Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound | 分子名称: | CALCIUM ION, Collagenase 3, ZINC ION, ... | 著者 | Shieh, H.-S, Collins, B, Schnute, M.E. | 登録日 | 2009-10-26 | 公開日 | 2010-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorg.Med.Chem.Lett., 20, 2009
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3KEJ
| Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound | 分子名称: | 4-[(5-{2-[(3-fluorobenzyl)carbamoyl]pyridin-4-yl}-2H-tetrazol-2-yl)methyl]benzoic acid, CALCIUM ION, Collagenase 3, ... | 著者 | Shieh, H.-S, Collins, B, Schnute, M.E. | 登録日 | 2009-10-26 | 公開日 | 2010-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorg.Med.Chem.Lett., 20, 2010
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3C1N
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1GOU
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3DNG
| Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor | 分子名称: | (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide, CALCIUM ION, Neutrophil collagenase, ... | 著者 | Pochetti, G, Montanari, R, Mazza, F. | 登録日 | 2008-07-02 | 公開日 | 2009-03-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8) J.Med.Chem., 52, 2009
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3DPE
| Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor | 分子名称: | CALCIUM ION, N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl}-4-oxo-3,5,6,8-tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidine-2-carboxamide 7,7-dioxide, Neutrophil collagenase, ... | 著者 | Pochetti, G, Montanari, R, Mazza, F. | 登録日 | 2008-07-08 | 公開日 | 2009-03-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8) J.Med.Chem., 52, 2009
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3DPF
| Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor | 分子名称: | ACETOHYDROXAMIC ACID, CALCIUM ION, N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl}-4-oxo-3,5,6,8-tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidine-2-carboxamide 7,7-dioxide, ... | 著者 | Pochetti, G, Montanari, R, Mazza, F. | 登録日 | 2008-07-08 | 公開日 | 2009-03-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8) J.Med.Chem., 52, 2009
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3C1M
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1ZVX
| Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer) | 分子名称: | (1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID, CALCIUM ION, Neutrophil collagenase, ... | 著者 | Pochetti, G, Gavuzzo, E, Campestre, C, Agamennone, M, Tortorella, P, Consalvi, V, Gallina, C, Hiller, O, Tschesche, H, Tucker, P.A, Mazza, F. | 登録日 | 2005-06-03 | 公開日 | 2006-05-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. J.Med.Chem., 49, 2006
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1ZS0
| Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (S-enantiomer) | 分子名称: | (1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Pochetti, G, Gavuzzo, E, Campestre, C, Agamennone, M, Tortorella, P, Consalvi, V, Gallina, C, Hiller, O, Tschesche, H, Tucker, P.A, Mazza, F. | 登録日 | 2005-05-23 | 公開日 | 2006-05-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. J.Med.Chem., 49, 2006
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1RGH
| HYDROLASE, GUANYLORIBONUCLEASE | 分子名称: | RIBONUCLEASE, SULFATE ION | 著者 | Sevcik, J, Dauter, Z, Lamzin, V.S, Wilson, K.S. | 登録日 | 1995-06-05 | 公開日 | 1996-10-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Ribonuclease from Streptomyces aureofaciens at atomic resolution. Acta Crystallogr.,Sect.D, 52, 1996
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1RGE
| HYDROLASE, GUANYLORIBONUCLEASE | 分子名称: | GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE, SULFATE ION | 著者 | Sevcik, J, Dauter, Z, Lamzin, V.S, Wilson, K.S. | 登録日 | 1995-06-05 | 公開日 | 1996-10-14 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Ribonuclease from Streptomyces aureofaciens at atomic resolution. Acta Crystallogr.,Sect.D, 52, 1996
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1RSN
| RIBONUCLEASE (RNASE SA) (E.C.3.1.4.8) COMPLEXED WITH EXO-2',3'-CYCLOPHOSPHOROTHIOATE | 分子名称: | GUANOSINE-2',3'-CYCLOPHOSPHOROTHIOATE, RIBONUCLEASE SA, SULFATE ION | 著者 | Sevcik, J, Dauter, Z, Lamzin, V.S, Wilson, K.S. | 登録日 | 1995-09-01 | 公開日 | 1995-12-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Complex of ribonuclease Sa with a cyclic nucleotide and a proposed model for the reaction intermediate. Eur.J.Biochem., 216, 1993
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1RGF
| HYDROLASE, GUANYLORIBONUCLEASE | 分子名称: | RIBONUCLEASE, SULFATE ION | 著者 | Sevcik, J, Dauter, Z, Lamzin, V.S, Wilson, K.S. | 登録日 | 1995-06-05 | 公開日 | 1996-10-14 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Ribonuclease from Streptomyces aureofaciens at atomic resolution. Acta Crystallogr.,Sect.D, 52, 1996
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1RGG
| HYDROLASE, GUANYLORIBONUCLEASE | 分子名称: | RIBONUCLEASE, SULFATE ION | 著者 | Sevcik, J, Dauter, Z, Lamzin, V.S, Wilson, K.S. | 登録日 | 1995-06-05 | 公開日 | 1996-10-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Ribonuclease from Streptomyces aureofaciens at atomic resolution. Acta Crystallogr.,Sect.D, 52, 1996
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