4D0A
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5NL2
| cryo-EM structure of the mTMEM16A ion channel at 6.6 A resolution. | Descriptor: | Anoctamin-1 | Authors: | Paulino, C, Neldner, Y, Lam, K.M, Kalienkova, V, Brunner, J.D, Schenck, S, Dutzler, R. | Deposit date: | 2017-04-03 | Release date: | 2017-06-07 | Last modified: | 2018-02-28 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A. Elife, 6, 2017
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5OYB
| Structure of calcium-bound mTMEM16A chloride channel at 3.75 A resolution | Descriptor: | Anoctamin-1, CALCIUM ION | Authors: | Paulino, C, Kalienkova, V, Lam, K.M, Neldner, Y, Dutzler, R. | Deposit date: | 2017-09-08 | Release date: | 2017-12-20 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM. Nature, 552, 2017
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5OYG
| Structure of calcium-free mTMEM16A chloride channel at 4.06 A resolution | Descriptor: | Anoctamin-1 | Authors: | Paulino, C, Kalienkova, V, Lam, K.M, Neldner, Y, Dutzler, R. | Deposit date: | 2017-09-08 | Release date: | 2017-12-20 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM. Nature, 552, 2017
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4CZB
| Structure of the sodium proton antiporter MjNhaP1 from Methanocaldococcus jannaschii at pH 8. | Descriptor: | NA(+)/H(+) ANTIPORTER 1, POTASSIUM ION, TRIS(HYDROXYETHYL)AMINOMETHANE | Authors: | Woehlert, D, Paulino, C, Kapotova, E, Kuhlbrandt, W, Yildiz, O. | Deposit date: | 2014-04-16 | Release date: | 2014-12-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | 3D Em Map of the Sodium Proton Antiporter Mjnhap1 from Methanocaldococcus Jannaschii Elife, 3, 2014
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8BMP
| Cryo-EM structure of the folate-specific ECF transporter complex in MSP2N2 lipid nanodiscs bound to ATP and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Energy-coupling factor transporter ATP-binding protein EcfA1, ... | Authors: | Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J. | Deposit date: | 2022-11-10 | Release date: | 2023-08-02 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Expulsion mechanism of the substrate-translocating subunit in ECF transporters. Nat Commun, 14, 2023
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8BMS
| Cryo-EM structure of the mutant solitary ECF module 2EQ in MSP2N2 lipid nanodiscs in the ATPase closed and ATP-bound conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, ... | Authors: | Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J. | Deposit date: | 2022-11-10 | Release date: | 2023-08-02 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Expulsion mechanism of the substrate-translocating subunit in ECF transporters. Nat Commun, 14, 2023
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8BMR
| Cryo-EM structure of the wild-type solitary ECF module in MSP2N2 lipid nanodiscs in the ATPase open and nucleotide-free conformation | Descriptor: | Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, Energy-coupling factor transporter transmembrane protein EcfT | Authors: | Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J. | Deposit date: | 2022-11-10 | Release date: | 2023-08-02 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Expulsion mechanism of the substrate-translocating subunit in ECF transporters. Nat Commun, 14, 2023
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8BMQ
| Cryo-EM structure of the folate-specific ECF transporter complex in MSP2N2 lipid nanodiscs bound to AMP-PNP | Descriptor: | Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, Energy-coupling factor transporter transmembrane protein EcfT, ... | Authors: | Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J. | Deposit date: | 2022-11-10 | Release date: | 2023-08-02 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Expulsion mechanism of the substrate-translocating subunit in ECF transporters. Nat Commun, 14, 2023
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6HRA
| Cryo-EM structure of the KdpFABC complex in an E1 outward-facing state (state 1) | Descriptor: | POTASSIUM ION, Potassium-transporting ATPase ATP-binding subunit, Potassium-transporting ATPase KdpC subunit, ... | Authors: | Stock, C, Hielkema, L, Tascon, I, Wunnicke, D, Oostergetel, G.T, Azkargorta, M, Paulino, C, Haenelt, I. | Deposit date: | 2018-09-26 | Release date: | 2018-12-05 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structures of KdpFABC suggest a K+transport mechanism via two inter-subunit half-channels. Nat Commun, 9, 2018
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6HRB
| Cryo-EM structure of the KdpFABC complex in an E2 inward-facing state (state 2) | Descriptor: | POTASSIUM ION, Potassium-transporting ATPase ATP-binding subunit, Potassium-transporting ATPase KdpC subunit, ... | Authors: | Stock, C, Hielkema, L, Tascon, I, Wunnicke, D, Oostergetel, G.T, Azkargorta, M, Paulino, C, Haenelt, I. | Deposit date: | 2018-09-26 | Release date: | 2018-12-05 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of KdpFABC suggest a K+transport mechanism via two inter-subunit half-channels. Nat Commun, 9, 2018
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7NNP
| Rb-loaded cryo-EM structure of the E1-ATP KdpFABC complex. | Descriptor: | CARDIOLIPIN, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Potassium-transporting ATPase ATP-binding subunit, ... | Authors: | Silberberg, J.M, Corey, R.A, Hielkema, L, Stock, C, Stansfeld, P.J, Paulino, C, Haenelt, I. | Deposit date: | 2021-02-25 | Release date: | 2021-07-28 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC. Nat Commun, 12, 2021
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7NNL
| Cryo-EM structure of the KdpFABC complex in an E1-ATP conformation loaded with K+ | Descriptor: | CARDIOLIPIN, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, POTASSIUM ION, ... | Authors: | Silberberg, J.M, Corey, R.A, Hielkema, L, Stock, C, Stansfeld, P.J, Paulino, C, Haenelt, I. | Deposit date: | 2021-02-25 | Release date: | 2021-07-28 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC. Nat Commun, 12, 2021
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7BCS
| ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation. | Descriptor: | (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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6GCT
| cryo-EM structure of the human neutral amino acid transporter ASCT2 | Descriptor: | GLUTAMINE, Neutral amino acid transporter B(0) | Authors: | Garaeva, A.A, Oostergetel, G.T, Gati, C, Guskov, A, Paulino, C, Slotboom, D.J. | Deposit date: | 2018-04-19 | Release date: | 2018-06-13 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | Cryo-EM structure of the human neutral amino acid transporter ASCT2. Nat. Struct. Mol. Biol., 25, 2018
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8ON7
| FMRFa-bound Malacoceros FaNaC1 in lipid nanodiscs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FMRFamide, ... | Authors: | Kalienkova, V, Dandamudi, M, Paulino, C, Lynagh, T. | Deposit date: | 2023-04-01 | Release date: | 2024-02-14 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural basis for excitatory neuropeptide signaling. Nat.Struct.Mol.Biol., 2024
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8ONA
| FMRFa-bound Malacoceros FaNaC1 in lipid nanodiscs in presence of diminazene | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FMRFamide, neuropeptide, ... | Authors: | Kalienkova, V, Dandamudi, M, Paulino, C, Lynagh, T. | Deposit date: | 2023-04-01 | Release date: | 2024-02-14 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for excitatory neuropeptide signaling. Nat.Struct.Mol.Biol., 2024
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8ON9
| ASSFVRIa-bound Malacoceros FaNaC1 in lipid nanodiscs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ASSFVRIamide, ... | Authors: | Kalienkova, V, Dandamudi, M, Paulino, C, Lynagh, T. | Deposit date: | 2023-04-01 | Release date: | 2024-02-14 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural basis for excitatory neuropeptide signaling. Nat.Struct.Mol.Biol., 2024
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8ON8
| Apo Malacoceros FaNaC1 in lipid nanodiscs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FMRFamide-gated sodium channel 1 | Authors: | Kalienkova, V, Dandamudi, M, Paulino, C, Lynagh, T. | Deposit date: | 2023-04-01 | Release date: | 2024-02-14 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for excitatory neuropeptide signaling. Nat.Struct.Mol.Biol., 2024
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8PD8
| cAMP-bound SpSLC9C1 in lipid nanodiscs, dimer | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-12 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PD9
| cAMP-bound SpSLC9C1 in lipid nanodiscs, protomer state 1 | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-12 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PD2
| Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 1 | Descriptor: | Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-11 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PD5
| Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 3 | Descriptor: | Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-11 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PDU
| cGMP-bound SpSLC9C1 in lipid nanodiscs, dimer | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-12 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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8PD7
| Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 4 | Descriptor: | Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-11 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
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