2WPO
 
 | | HCMV protease inhibitor complex | | 分子名称: | (2S)-2-(3,3-dimethylbutanoylamino)-N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[(4-iodophenyl)methylamino]-4-oxo-butan-2-yl]amino]- 1,4-dioxo-4-pyrrol-1-yl-butan-2-yl]-3,3-dimethyl-butanamide, HUMAN CYTOMEGALOVIRUS PROTEASE | | 著者 | Tong, L, Qian, C, Massariol, M.-J, Deziel, R, Yoakim, C, Lagace, L. | | 登録日 | 1998-08-04 | | 公開日 | 1999-08-04 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease.
Nat.Struct.Biol., 5, 1998
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1BFZ
 | | BOUND CONFORMATION OF N-TERMINAL CLEAVAGE PRODUCT PEPTIDE MIMIC (P1-P9 OF RELEASE SITE) WHILE BOUND TO HCMV PROTEASE AS DETERMINED BY TRANSFERRED NOESY EXPERIMENTS (P1-P5 SHOWN ONLY), NMR, 32 STRUCTURES | | 分子名称: | HCMV PROTEASE R-SITE N-TERMINAL CLEAVAGE PRODUCT | | 著者 | Laplante, S.R, Aubry, N, Bonneau, P.R, Cameron, D.R, Lagace, L, Massariol, M.-J, Montpetit, H, Ploufe, C, Kawai, S.H, Fulton, B.D, Chen, Z, Ni, F. | | 登録日 | 1998-05-25 | | 公開日 | 1999-05-25 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Human cytomegalovirus protease complexes its substrate recognition sequences in an extended peptide conformation.
Biochemistry, 37, 1998
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1IEG
 | | CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT S134A/H157A OF THE HUMAN CYTOMEGALOVIRUS PROTEASE | | 分子名称: | CAPSID PROTEIN P40: ASSEMBLIN PROTEASE | | 著者 | Khayat, R, Batra, R, Massariol, M.J, Lagace, L, Tong, L. | | 登録日 | 2001-04-09 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Biochemistry, 40, 2001
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1IEF
 | | CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT S134A OF THE HUMAN CYTOMEGALOVIRUS PROTEASE | | 分子名称: | CAPSID PROTEIN P40: ASSEMBLIN PROTEASE | | 著者 | Khayat, R, Batra, R, Massariol, M.J, Lagace, L, Tong, L. | | 登録日 | 2001-04-09 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Biochemistry, 40, 2001
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1ID4
 | | CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT (H157Q) OF THE HUMAN CYTOMEGALOVIRUS PROTEASE | | 分子名称: | CAPSID PROTEIN P40: ASSEMBLIN PROTEASE | | 著者 | Khayat, R, Batra, R, Massariol, M.J, Lagace, L, Tong, L. | | 登録日 | 2001-04-03 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Biochemistry, 40, 2001
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1IEC
 | | CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT (H157A) OF THE HUMAN CYTOMEGALOVIRUS PROTEASE | | 分子名称: | CAPSID PROTEIN P40: ASSEMBLIN PROTEASE | | 著者 | Khayat, R, Batra, R, Massariol, M.J, Lagace, L, Tong, L. | | 登録日 | 2001-04-09 | | 公開日 | 2001-06-06 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Biochemistry, 40, 2001
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1IED
 | | CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT (H157E) OF THE HUMAN CYTOMEGALOVIRUS PROTEASE | | 分子名称: | CAPSID PROTEIN P40: ASSEMBLIN PROTEASE | | 著者 | Khayat, R, Batra, R, Massariol, M.J, Lagace, L, Tong, L. | | 登録日 | 2001-04-09 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Biochemistry, 40, 2001
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1WPO
 | | HYDROLYTIC ENZYME HUMAN CYTOMEGALOVIRUS PROTEASE | | 分子名称: | HUMAN CYTOMEGALOVIRUS PROTEASE, SULFATE ION | | 著者 | Tong, L. | | 登録日 | 1996-07-23 | | 公開日 | 1997-10-15 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease.
Nature, 383, 1996
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4I32
 | | Crystal structure of HCV NS3/4A D168V protease complexed with compound 4 | | 分子名称: | (2R,6S,7E,10E,13aR,14aR,16aS)-2-{[7-methoxy-8-methyl-2-(propan-2-yloxy)quinolin-4-yl]oxy}-N-[(1-methylcyclopropyl)sulfonyl]-6-{[(1-methyl-1H-pyrazol-3-yl)carbonyl]amino}-5,16-dioxo-1,2,3,6,9,12,13,13a,14,15,16,16a-dodecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide, Genome polyprotein, HCV non-structural protein 4A, ... | | 著者 | Lemke, C.T. | | 登録日 | 2012-11-23 | | 公開日 | 2013-01-02 | | 最終更新日 | 2013-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3001 Å) | | 主引用文献 | Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance.
J.Biol.Chem., 288, 2013
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4I33
 | | Crystal structure of HCV NS3/4A R155K protease complexed with compound 4 | | 分子名称: | (2R,6S,7E,10E,13aR,14aR,16aS)-2-{[7-methoxy-8-methyl-2-(propan-2-yloxy)quinolin-4-yl]oxy}-N-[(1-methylcyclopropyl)sulfonyl]-6-{[(1-methyl-1H-pyrazol-3-yl)carbonyl]amino}-5,16-dioxo-1,2,3,6,9,12,13,13a,14,15,16,16a-dodecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide, Genome polyprotein, HCV non-structural protein 4A, ... | | 著者 | Lemke, C.T. | | 登録日 | 2012-11-23 | | 公開日 | 2013-01-02 | | 最終更新日 | 2013-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.9001 Å) | | 主引用文献 | Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance.
J.Biol.Chem., 288, 2013
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4I31
 | | Crystal structure of HCV NS3/NS4A protease complexed with compound 4 | | 分子名称: | (2R,6S,7E,10E,13aR,14aR,16aS)-2-{[7-methoxy-8-methyl-2-(propan-2-yloxy)quinolin-4-yl]oxy}-N-[(1-methylcyclopropyl)sulfonyl]-6-{[(1-methyl-1H-pyrazol-3-yl)carbonyl]amino}-5,16-dioxo-1,2,3,6,9,12,13,13a,14,15,16,16a-dodecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide, Genome polyprotein, HCV non-structural protein 4A, ... | | 著者 | Lemke, C.T. | | 登録日 | 2012-11-23 | | 公開日 | 2013-01-02 | | 最終更新日 | 2013-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.9301 Å) | | 主引用文献 | Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance.
J.Biol.Chem., 288, 2013
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3CLN
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