1XH4
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | Descriptor: | N-[4-({4-[5-(DIMETHYLAMINO)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | Authors: | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | Deposit date: | 2004-09-17 | Release date: | 2005-09-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
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1IXO
| Enzyme-analogue substrate complex of Pyridoxine 5'-Phosphate Synthase | Descriptor: | Pyridoxine 5'-Phosphate synthase, SN-GLYCEROL-3-PHOSPHATE | Authors: | Garrido-Franco, M, Laber, B, Huber, R, Clausen, T. | Deposit date: | 2002-06-28 | Release date: | 2003-02-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis J.MOL.BIOL., 321, 2002
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1IXQ
| Enzyme-Phosphate2 Complex of Pyridoxine 5'-Phosphate synthase | Descriptor: | PHOSPHATE ION, Pyridoxine 5'-phosphate Synthase | Authors: | Garrido-Franco, M, Laber, B, Huber, R, Clausen, T. | Deposit date: | 2002-06-28 | Release date: | 2003-02-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis J.MOL.BIOL., 321, 2002
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1IXP
| Enzyme-phosphate Complex of Pyridoxine 5'-Phosphate synthase | Descriptor: | PHOSPHATE ION, Pyridoxine 5'-Phosphate synthase | Authors: | Garrido-Franco, M, Laber, B, Huber, R, Clausen, T. | Deposit date: | 2002-06-28 | Release date: | 2003-02-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis J.MOL.BIOL., 321, 2002
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2NAP
| DISSIMILATORY NITRATE REDUCTASE (NAP) FROM DESULFOVIBRIO DESULFURICANS | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, IRON/SULFUR CLUSTER, ... | Authors: | Dias, J.M, Than, M, Humm, A, Huber, R, Bourenkov, G, Bartunik, H, Bursakov, S, Calvete, J, Caldeira, J, Carneiro, C, Moura, J, Moura, I, Romao, M.J. | Deposit date: | 1998-09-18 | Release date: | 1999-09-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the first dissimilatory nitrate reductase at 1.9 A solved by MAD methods. Structure Fold.Des., 7, 1999
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1IXN
| Enzyme-Substrate Complex of Pyridoxine 5'-Phosphate Synthase | Descriptor: | 1-DEOXY-D-XYLULOSE-5-PHOSPHATE, Pyridoxine 5'-Phosphate Synthase, SN-GLYCEROL-3-PHOSPHATE | Authors: | Garrido-Franco, M, Laber, B, Huber, R, Clausen, T. | Deposit date: | 2002-06-28 | Release date: | 2003-02-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis J.MOL.BIOL., 321, 2002
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2GSR
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2HSA
| Crystal structure of 12-oxophytodienoate reductase 3 (OPR3) from tomato | Descriptor: | 12-oxophytodienoate reductase 3, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ... | Authors: | Breithaupt, C, Clausen, T, Huber, R. | Deposit date: | 2006-07-21 | Release date: | 2006-09-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of 12-oxophytodienoate reductase 3 from tomato: Self-inhibition by dimerization. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HS6
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2HS8
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3V3B
| Structure of the Stapled p53 Peptide Bound to Mdm2 | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, SAH-p53-8 stapled-peptide | Authors: | Baek, S, Kutchukian, P.S, Verdine, G.L, Huber, R, Holak, T.A, Ki Won, L, Popowicz, G.M. | Deposit date: | 2011-12-13 | Release date: | 2012-01-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the stapled p53 peptide bound to Mdm2. J.Am.Chem.Soc., 134, 2012
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3V3V
| Structural and functional analysis of quercetagetin, a natural JNK1 inhibitor | Descriptor: | 3,5,6,7-TETRAHYDROXY-2-(3,4-DIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, C-Jun-amino-terminal kinase-interacting protein 1, CHLORIDE ION, ... | Authors: | Baek, S, Kang, N.J, Popowicz, G.M, Arciniega, M, Jung, S.K, Byun, S, Song, N.R, Heo, Y.S, Kim, B.Y, Lee, H.J, Holak, T.A, Augustin, M, Bode, A.M, Huber, R, Dong, Z, Lee, K.W. | Deposit date: | 2011-12-14 | Release date: | 2012-12-05 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin. J.Mol.Biol., 425, 2013
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2IMM
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1KLO
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1REI
| THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION | Descriptor: | BENCE-JONES PROTEIN REI (LIGHT CHAIN) | Authors: | Epp, O, Lattman, E.E, Colman, P, Fehlhammer, H, Bode, W, Schiffer, M, Huber, R, Palm, W. | Deposit date: | 1976-03-17 | Release date: | 1976-05-19 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-A resolution. Biochemistry, 14, 1975
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1NPS
| CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF PROTEIN S | Descriptor: | CALCIUM ION, DEVELOPMENT-SPECIFIC PROTEIN S | Authors: | Wenk, M, Baumgartner, R, Mayer, E.M, Huber, R, Holak, T.A, Jaenicke, R. | Deposit date: | 1999-02-01 | Release date: | 2000-02-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The domains of protein S from Myxococcus xanthus: structure, stability and interactions. J.Mol.Biol., 286, 1999
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1TOC
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1JC9
| TACHYLECTIN 5A FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, techylectin-5A | Authors: | Kairies, N, Beisel, H.-G, Fuentes-Prior, P, Tsuda, R, Muta, T, Iwanaga, S, Bode, W, Huber, R, Kawabata, S. | Deposit date: | 2001-06-08 | Release date: | 2001-11-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems. Proc.Natl.Acad.Sci.USA, 98, 2001
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1PIG
| PIG PANCREATIC ALPHA-AMYLASE COMPLEXED WITH THE OLIGOSACCHARIDE V-1532 | Descriptor: | 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, ... | Authors: | Machius, M, Vertesy, L, Huber, R, Wiegand, G. | Deposit date: | 1996-06-15 | Release date: | 1996-12-07 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Carbohydrate and protein-based inhibitors of porcine pancreatic alpha-amylase: structure analysis and comparison of their binding characteristics. J.Mol.Biol., 260, 1996
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1PIF
| PIG ALPHA-AMYLASE | Descriptor: | ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION | Authors: | Machius, M, Vertesy, L, Huber, R, Wiegand, G. | Deposit date: | 1996-06-15 | Release date: | 1996-12-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Carbohydrate and protein-based inhibitors of porcine pancreatic alpha-amylase: structure analysis and comparison of their binding characteristics. J.Mol.Biol., 260, 1996
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1JK3
| Crystal structure of human MMP-12 (Macrophage Elastase) at true atomic resolution | Descriptor: | 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, CALCIUM ION, MACROPHAGE METALLOELASTASE, ... | Authors: | Lang, R, Kocourek, A, Braun, M, Tschesche, H, Huber, R, Bode, W, Maskos, K. | Deposit date: | 2001-07-11 | Release date: | 2001-09-28 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure. J.Mol.Biol., 312, 2001
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1WLH
| Molecular structure of the rod domain of Dictyostelium filamin | Descriptor: | Gelation factor | Authors: | Popowicz, G.M, Mueller, R, Noegel, A.A, Schleicher, M, Huber, R, Holak, T.A. | Deposit date: | 2004-06-27 | Release date: | 2004-10-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular structure of the rod domain of dictyostelium filamin J.Mol.Biol., 342, 2004
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1M4Y
| Crystal structure of HslV from Thermotoga maritima | Descriptor: | ATP-dependent protease hslV, SODIUM ION | Authors: | Song, H.K, Ramachandran, R, Bochtler, M.B, Hartmann, C, Azim, M.K, Huber, R. | Deposit date: | 2002-07-05 | Release date: | 2003-05-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV. BIOPHYS.CHEM., 100, 2003
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3MH6
| HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues | Descriptor: | DIISOPROPYL PHOSPHONATE, Protease do | Authors: | Krojer, T, Sawa, J, Huber, R, Clausen, T. | Deposit date: | 2010-04-07 | Release date: | 2010-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues Nat.Struct.Mol.Biol., 17, 2010
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3MH4
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