2D4U
 
 | | Crystal Structure of the ligand binding domain of the bacterial serine chemoreceptor Tsr | | 分子名称: | Methyl-accepting chemotaxis protein I | | 著者 | Imada, K, Tajima, H, Namba, K, Sakuma, M, Homma, M, Kawagishi, I. | | 登録日 | 2005-10-24 | | 公開日 | 2006-11-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Ligand specificity determined by differentially arranged common ligand-binding residues in the bacterial amino acid chemoreceptors Tsr and Tar.
J.Biol.Chem., 2011
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6IF6
 | | Structure of the periplasmic domain of SflA | | 分子名称: | GLYCEROL, PHOSPHATE ION, Protein SflA | | 著者 | Nishikawa, S, Sakuma, M, Kojima, S, Homma, M, Imada, K. | | 登録日 | 2018-09-18 | | 公開日 | 2019-05-01 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of the periplasmic domain of SflA involved in spatial regulation of the flagellar biogenesis of Vibrio reveals a TPR/SLR-like fold.
J.Biochem., 166, 2019
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7CIK
 | | Structure of the 58-213 fragment of FliF | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, Flagellar M-ring protein | | 著者 | Takekawa, T, Sakuma, M, Kojima, S, Homma, M, Imada, K. | | 登録日 | 2020-07-07 | | 公開日 | 2021-02-17 | | 最終更新日 | 2021-09-01 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Two Distinct Conformations in 34 FliF Subunits Generate Three Different Symmetries within the Flagellar MS-Ring.
Mbio, 12, 2021
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5Y3Z
 | | Structure of the periplasmic domain of the MotB L119P mutant from Salmonella (crystal form 1) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ARGININE, IMIDAZOLE, ... | | 著者 | Takao, M, Kojima, S, Sakuma, M, Homma, M, Imada, K. | | 登録日 | 2017-07-31 | | 公開日 | 2018-04-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Helix Rearrangement in the Periplasmic Domain of the Flagellar Stator B Subunit Activates Peptidoglycan Binding and Ion Influx.
Structure, 26, 2018
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5Y40
 | | Structure of the periplasmic domain of the MotB L119P mutant from Salmonella (crystal form 2) | | 分子名称: | Motility protein B | | 著者 | Takao, M, Kojima, S, Sakuma, M, Homma, M, Imada, K. | | 登録日 | 2017-07-31 | | 公開日 | 2018-04-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The Helix Rearrangement in the Periplasmic Domain of the Flagellar Stator B Subunit Activates Peptidoglycan Binding and Ion Influx.
Structure, 26, 2018
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6AHP
 | | Structure of the 58-167 fragment of FliL | | 分子名称: | Flagellar protein FliL | | 著者 | Takekawa, N, Isumi, M, Sakuma, M, Kojima, S, Homma, M, Imada, K. | | 登録日 | 2018-08-20 | | 公開日 | 2019-03-06 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure ofVibrioFliL, a New Stomatin-like Protein That Assists the Bacterial Flagellar Motor Function.
MBio, 10, 2019
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6AHQ
 | | Structure of the 40-167 fragment of FliL | | 分子名称: | Flagellar protein FliL | | 著者 | Takekawa, N, Isumi, M, Sakuma, M, Kojima, S, Homma, M, Imada, K. | | 登録日 | 2018-08-20 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.398 Å) | | 主引用文献 | Structure ofVibrioFliL, a New Stomatin-like Protein That Assists the Bacterial Flagellar Motor Function.
MBio, 10, 2019
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7DM9
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7DMA
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2ZVY
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2ZF8
 | | Crystal structure of MotY | | 分子名称: | Component of sodium-driven polar flagellar motor | | 著者 | Imada, K, Kojima, S, Namba, K, Homma, M. | | 登録日 | 2007-12-25 | | 公開日 | 2008-07-08 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Insights into the stator assembly of the Vibrio flagellar motor from the crystal structure of MotY
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2ZOV
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3W1E
 | | Structure of FlgT, a flagellar basal body component protein | | 分子名称: | Flagella basal-body protein | | 著者 | Terashima, H, Sakuma, M, Homma, M, Imada, K. | | 登録日 | 2012-11-14 | | 公開日 | 2013-04-03 | | 最終更新日 | 2013-08-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Insight into the assembly mechanism in the supramolecular rings of the sodium-driven Vibrio flagellar motor from the structure of FlgT
Proc.Natl.Acad.Sci.USA, 110, 2013
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3WPW
 | | Structure of PomBc5, a periplasmic fragment of PomB from Vibrio | | 分子名称: | ACETATE ION, PomB | | 著者 | Takao, M, Sakuma, M, Zhu, S, Homma, M, Kojima, S, Imada, K. | | 登録日 | 2014-01-17 | | 公開日 | 2014-09-10 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Conformational change in the periplasmic region of the flagellar stator coupled with the assembly around the rotor
Proc. Natl. Acad. Sci. U.S.A., 111, 2014
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3WPX
 | | Structure of PomBc4, a periplasmic fragment of PomB from Vibrio alginolyticus | | 分子名称: | PomB | | 著者 | Takao, M, Sakuma, M, Zhu, S, Homma, M, Kojima, S, Imada, K. | | 登録日 | 2014-01-17 | | 公開日 | 2014-09-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Conformational change in the periplasmic region of the flagellar stator coupled with the assembly around the rotor
Proc. Natl. Acad. Sci. U.S.A., 111, 2014
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3W0D
 | | Structure of elastase inhibitor AFUEI (cyrstal form I) | | 分子名称: | Elastase inhibitor AFUEI | | 著者 | Imada, K, Sakuma, M, Okumura, Y, Ogawa, K, Nikai, T, Homma, M. | | 登録日 | 2012-10-29 | | 公開日 | 2013-05-15 | | 最終更新日 | 2013-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | X-ray Structure Analysis and Characterization of AFUEI, an Elastase Inhibitor from Aspergillus fumigatus
J.Biol.Chem., 288, 2013
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3W0E
 | | Structure of elastase inhibitor AFUEI (crystal form II) | | 分子名称: | Elastase inhibitor AFUEI | | 著者 | Imada, K, Sakuma, M, Okumura, Y, Ogawa, K, Nikai, T, Homma, M. | | 登録日 | 2012-10-29 | | 公開日 | 2013-05-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | X-ray Structure Analysis and Characterization of AFUEI, an Elastase Inhibitor from Aspergillus fumigatus
J.Biol.Chem., 288, 2013
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3ATP
 | | Structure of the ligand binding domain of the bacterial serine chemoreceptor Tsr with ligand | | 分子名称: | Methyl-accepting chemotaxis protein I, SERINE | | 著者 | Tajima, H, Sakuma, M, Homma, K, Kawagishi, I, Imada, K. | | 登録日 | 2011-01-07 | | 公開日 | 2011-10-19 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Ligand specificity determined by differentially arranged common ligand-binding residues in bacterial amino acid chemoreceptors Tsr and Tar.
J.Biol.Chem., 286, 2011
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8GQY
 | | CryoEM structure of pentameric MotA from Aquifex aeolicus | | 分子名称: | Motility protein A | | 著者 | Nishikino, T, Takekawa, N, Kishikawa, J, Hirose, M, Onoe, S, Kato, T, Imada, K. | | 登録日 | 2022-08-31 | | 公開日 | 2022-10-26 | | 最終更新日 | 2022-11-09 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of MotA, a flagellar stator protein, from hyperthermophile.
Biochem.Biophys.Res.Commun., 631, 2022
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6P5M
 | | Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Anti-Tumor Agent | | 分子名称: | 6-(5-methyl-1H-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3H)-one, Rho-associated protein kinase 2 | | 著者 | Hoffman, I.D, Skene, R.J. | | 登録日 | 2019-05-30 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent.
J.Med.Chem., 63, 2020
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6P5P
 | | Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Anti-Tumor Agent | | 分子名称: | 2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one, Rho-associated protein kinase 2 | | 著者 | Hoffman, I.D, Skene, R.J. | | 登録日 | 2019-05-30 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent.
J.Med.Chem., 63, 2020
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2ZVZ
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5U7Q
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5U7R
 | | Identification of A New Class of Potent Cdc7 Inhibitors Designed by Putative Pharmacophore Model: Synthesis and Biological Evaluation of 2,3-Dihydrothieno[3,2-d]pyrimidin-4(1H)-ones | | 分子名称: | (1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1H-pyrazol-4-yl)-1'H-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'H)-one, Rho-associated protein kinase 2 | | 著者 | Hoffman, I.D, Skene, R.J. | | 登録日 | 2016-12-12 | | 公開日 | 2017-03-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | | 主引用文献 | Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.
Bioorg. Med. Chem., 25, 2017
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5AVE
 | | The ligand binding domain of Mlp37 with serine | | 分子名称: | Methyl-accepting chemotaxis (MCP) signaling domain protein, SERINE | | 著者 | Takahashi, Y, Sumita, K, Uchida, Y, Nishiyama, S, Kawagishi, I, Imada, K. | | 登録日 | 2015-06-15 | | 公開日 | 2016-03-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants
Sci Rep, 6, 2016
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