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Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog or DNA containing an abasic site and a free nucleobase (33% substrate/67% product at 72 hours)
Descriptor:	7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(CPCPCPGPAP(DZM)PAPGPTPCPCPG)-3'), ...
Authors:	Mullins, E.A, Eichman, B.F.
Deposit date:	2015-07-16
Release date:	2015-10-28
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.541 Å)
Cite:	The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions. Nature, 527, 2015

Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog or DNA containing an abasic site and a free nucleobase (51% substrate/49% product at 48 hours)
Descriptor:	7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(CPCPCPGPAP(DZM)PAPGPTPCPCPG)-3'), ...
Authors:	Mullins, E.A, Eichman, B.F.
Deposit date:	2015-07-16
Release date:	2015-10-28
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.569 Å)
Cite:	The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions. Nature, 527, 2015

Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog (9-mer B)
Descriptor:	AlkD, DNA (5'-D(APAPGPCPCP(DZM)PCPCPC)-3'), DNA (5'-D(TPGPGPGPTPGPGPCPT)-3')
Authors:	Mullins, E.A, Eichman, B.F.
Deposit date:	2015-07-16
Release date:	2015-10-28
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.729 Å)
Cite:	The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions. Nature, 527, 2015

Structure of mammalian NEIL2 from Monodelphis domestica in complex with THF-containing DNA
Descriptor:	DIMETHYL SULFOXIDE, DNA (5'-D(GPCPGPTPCPCPAP(3DR)PGPTPCPTPAPC)-3'), DNA (5'-D(GPTPAPGPAPCPCPTPGPGPAPCP*G)-3'), ...
Authors:	Eckenroth, B.E, Doublie, S.
Deposit date:	2023-07-14
Release date:	2023-11-01
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.08 Å)
Cite:	Structural and biochemical insights into NEIL2's preference for abasic sites. Nucleic Acids Res., 51, 2023