2KQH
 
 | | A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics | | 分子名称: | 5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*GP*CP*GP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3', POTASSIUM ION | | 著者 | Hsu, S.-T.D, Varnai, P, Bugaut, A, Reszka, A.P, Neidle, S, Balasubramanian, S. | | 登録日 | 2009-11-05 | | 公開日 | 2009-11-24 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
J.Am.Chem.Soc., 131, 2009
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2KQG
 | | A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics | | 分子名称: | 5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*AP*CP*GP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3', POTASSIUM ION | | 著者 | Hsu, S.-T.D, Varnai, P, Bugaut, A, Reszka, A.P, Neidle, S, Balasubramanian, S. | | 登録日 | 2009-11-05 | | 公開日 | 2009-11-24 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
J.Am.Chem.Soc., 131, 2009
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4QKK
 | | Crystal structure of an oligonucleotide containing 5-formylcytosine | | 分子名称: | DNA (5'-D(*CP*TP*AP*(5FC)P*GP*(5FC)P*GP*(5FC)P*GP*TP*AP*G)-3') | | 著者 | Raiber, E.-A, Murat, P, Chirgadze, D.Y, Luisi, B.F, Balasubramanian, S. | | 登録日 | 2014-06-06 | | 公開日 | 2014-12-10 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | 5-Formylcytosine alters the structure of the DNA double helix.
Nat.Struct.Mol.Biol., 22, 2015
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6AC7
 | | Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter | | 分子名称: | 5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*GP*AP*GP*GP*CP*GP*GP*GP*GP*CP*TP*TP*GP*GP*G)-3' | | 著者 | Sengar, A, Vandana, J.J, Chambers, V.S, Di Antonio, M, Winnerdy, F.R, Balasubramanian, S, Phan, A.T. | | 登録日 | 2018-07-25 | | 公開日 | 2019-02-27 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.
Nucleic Acids Res., 47, 2019
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4XK0
 | | Crystal structure of a tetramolecular RNA G-quadruplex in potassium | | 分子名称: | BARIUM ION, POTASSIUM ION, RNA (5'-(*UP*GP*GP*GP*GP*U)-3') | | 著者 | Chen, M.C, Murat, P, Abecassis, K.A, Ferre-D'Amare, A.R, Balasubramanian, S. | | 登録日 | 2015-01-09 | | 公開日 | 2015-02-11 | | 最終更新日 | 2015-08-19 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase.
Nucleic Acids Res., 43, 2015
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5LS6
 | | Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor | | 分子名称: | 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ... | | 著者 | Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S. | | 登録日 | 2016-08-22 | | 公開日 | 2017-02-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.47 Å) | | 主引用文献 | Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
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5DNI
 | | Crystal structure of Methanocaldococcus jannaschii Fumarate hydratase beta subunit | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Jayaraman, V, Kunala, J, Balaram, H. | | 登録日 | 2015-09-10 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Revisiting the Burden Borne by Fumarase: Enzymatic Hydration of an Olefin.
Biochemistry, 62, 2023
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7U0H
 | | State NE1 nucleolar 60S ribosome biogenesis intermediate - Overall model | | 分子名称: | 25S rRNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, 5.8S rRNA, ... | | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | | 登録日 | 2022-02-18 | | 公開日 | 2022-12-14 | | 最終更新日 | 2022-12-28 | | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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5VHE
 | | DHX36 in complex with the c-Myc G-quadruplex | | 分子名称: | DEAH (Asp-Glu-Ala-His) box polypeptide 36, DNA (5'-D(*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*TP*TP*TP*TP*TP*T)-3'), POTASSIUM ION | | 著者 | Chen, M, Ferre-D'Amare, A. | | 登録日 | 2017-04-13 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.793 Å) | | 主引用文献 | Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Nature, 558, 2018
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5VHD
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5VHC
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5VHA
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7D40
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7D95
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7NAC
 | | State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model | | 分子名称: | 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | | 登録日 | 2021-06-21 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-12-28 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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7NAF
 | | State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb1-MTD local model | | 分子名称: | 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | | 登録日 | 2021-06-21 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-12-28 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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7NAD
 | | State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb4 local refinement model | | 分子名称: | 25S rRNA, 5.8S rRNA, 60S ribosomal protein L17-A, ... | | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | | 登録日 | 2021-06-21 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-12-28 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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7D96
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7D97
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7XKY
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7R7O
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7R6K
 | | State E2 nucleolar 60S ribosomal intermediate - Model for Noc2/Noc3 region | | 分子名称: | 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | | 登録日 | 2021-06-22 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-12-28 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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7R7A
 | | State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model | | 分子名称: | 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | | 登録日 | 2021-06-24 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-12-28 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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7R6Q
 | | State E2 nucleolar 60S ribosome biogenesis intermediate - Foot region model | | 分子名称: | 25S rRNA, 5.8S rRNA, 60S ribosomal protein L13-A, ... | | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | | 登録日 | 2021-06-23 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-12-28 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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7R72
 | | State E1 nucleolar 60S ribosome biogenesis intermediate - Spb4 local model | | 分子名称: | 25S rRNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, 5.8S rRNA, ... | | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | | 登録日 | 2021-06-24 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-12-28 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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