3BOS
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![BU of 3bos by Molmil](/molmil-images/mine/3bos) | |
2ETS
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![BU of 2ets by Molmil](/molmil-images/mine/2ets) | |
2HBW
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![BU of 2hbw by Molmil](/molmil-images/mine/2hbw) | |
2GVK
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![BU of 2gvk by Molmil](/molmil-images/mine/2gvk) | |
3DCX
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![BU of 3dcx by Molmil](/molmil-images/mine/3dcx) | |
3EQX
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![BU of 3eqx by Molmil](/molmil-images/mine/3eqx) | |
2EVR
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![BU of 2evr by Molmil](/molmil-images/mine/2evr) | |
2GVI
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![BU of 2gvi by Molmil](/molmil-images/mine/2gvi) | |
8PFO
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![BU of 8pfo by Molmil](/molmil-images/mine/8pfo) | Crystal structure of WRN helicase domain in complex with HRO761 | Descriptor: | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION, ~{N}-[2-chloranyl-4-(trifluoromethyl)phenyl]-2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-6-[4-(6-methyl-5-oxidanyl-pyrimidin-4-yl)carbonylpiperazin-1-yl]-7-oxidanylidene-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]ethanamide | Authors: | Scheufler, C, Meyer, M, Moebitz, H. | Deposit date: | 2023-06-16 | Release date: | 2024-04-24 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Nature, 629, 2024
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8PFP
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![BU of 8pfp by Molmil](/molmil-images/mine/8pfp) | |
8PFL
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![BU of 8pfl by Molmil](/molmil-images/mine/8pfl) | Crystal structure of WRN helicase domain in complex with 3 | Descriptor: | 2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-7-oxidanylidene-6-[4-(3-oxidanylpyridin-2-yl)carbonylpiperazin-1-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]-~{N}-[2-methyl-4-(trifluoromethyl)phenyl]ethanamide, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION | Authors: | Scheufler, C, Meyer, M, Moebitz, H. | Deposit date: | 2023-06-16 | Release date: | 2024-04-24 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Nature, 629, 2024
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