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4G34
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BU of 4g34 by Molmil
Crystal Structure of GSK6924 Bound to PERK (R587-R1092, delete A660-T867) at 2.70 A Resolution
Descriptor: 1-[5-(4-aminothieno[3,2-c]pyridin-3-yl)-2,3-dihydro-1H-indol-1-yl]-2-phenylethanone, Eukaryotic translation initiation factor 2-alpha kinase 3
Authors:Gampe, R.T, Axten, J.M.
Deposit date:2012-07-13
Release date:2012-08-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK).
J.Med.Chem., 55, 2012
4G31
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BU of 4g31 by Molmil
Crystal Structure of GSK6414 Bound to PERK (R587-R1092, delete A660-T867) at 2.28 A Resolution
Descriptor: 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone, Eukaryotic translation initiation factor 2-alpha kinase 3, GLYCEROL
Authors:Gampe, R.T, Axten, J.M.
Deposit date:2012-07-13
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK).
J.Med.Chem., 55, 2012
6RXG
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BU of 6rxg by Molmil
Crystal Structure of Bifidobacterium longum Multiple Inositol Polyphosphate Phosphatase Complex with Phosphate
Descriptor: Histidine acid phosphatase, PHOSPHATE ION, ZINC ION
Authors:Zietek, M.A.Z, Brearley, C.A, Hemmings, A.M.
Deposit date:2019-06-07
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism.
J.Biol.Chem., 295, 2020
6RXE
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BU of 6rxe by Molmil
Crystal Structure of Bifidobacterium longum Multiple Inositol Polyphosphate Phosphatase Complex with Inositol Hexasulfate
Descriptor: D-MYO-INOSITOL-HEXASULPHATE, Histidine acid phosphatase, PHOSPHATE ION
Authors:Acquistapace, I.M, Brearley, C.A, Hemmings, A.M.
Deposit date:2019-06-07
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism.
J.Biol.Chem., 295, 2020
6RXF
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BU of 6rxf by Molmil
Crystal Structure of Bifidobacterium longum Multiple Inositol Polyphosphate Phosphatase Phosphohistidine Intermediate
Descriptor: Histidine acid phosphatase, ZINC ION
Authors:Acquistapace, I.M, Brearley, C.A, Hemmings, A.M.
Deposit date:2019-06-07
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.397 Å)
Cite:Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism.
J.Biol.Chem., 295, 2020
4M7I
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BU of 4m7i by Molmil
Crystal Structure of GSK6157 Bound to PERK (R587-R1092, delete A660-T867) at 2.34A Resolution
Descriptor: 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-1H-indol-1-yl]-2-(6-methylpyridin-2-yl)ethanone, Eukaryotic translation initiation factor 2-alpha kinase 3
Authors:Gampe, R.T, Axten, J.M.
Deposit date:2013-08-12
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Discovery of 5-{4-fluoro-1-[(6-methyl-2-pyridinyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2656157), a Potent and Selective PERK Inhibitor Selected for Preclinical Development
To be Published
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PDB entries from 2024-07-10

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