6H1X
 
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4AYF
 | | Crystal structure of the complex of the Caf1M:Caf1 chaperone:subunit preassembly complex carrying the Tyr40Ala mutation in the Caf1M chaperone | | Descriptor: | CHAPERONE PROTEIN CAF1M, F1 CAPSULE ANTIGEN | | Authors: | Yu, X.D, Dubnovitsky, A, Pudney, A.F, MacIntyre, S, Knight, S.D, Zavialov, A.V. | | Deposit date: | 2012-06-20 | | Release date: | 2012-09-26 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Allosteric Mechanism Controls Traffic in the Chaperone/Usher Pathway.
Structure, 20, 2012
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6H2L
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1QPP
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1QPX
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3DOS
 | | Crystal structure of the complex of the Caf1M chaperone with the mini-fiber of two Caf1 subunits (Caf1:Caf1), carrying the Thr7Phe and Ala9Val mutations in the Gd donor strand | | Descriptor: | Chaperone protein caf1M, F1 capsule antigen | | Authors: | Fooks, L.J, Yu, X, Moslehi-Mohebi, E, Tischenko, V, Knight, S.D, MacIntyre, S, Zavialov, A.V. | | Deposit date: | 2008-07-06 | | Release date: | 2009-07-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Hydrophobicity and rigidity of binding segments enable CAF1M chaperone to act as assembly catalyst
TO BE PUBLISHED
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3DPB
 | | Crystal structure of the complex of the Caf1M chaperone with the mini-fiber of two Caf1 subunits (Caf1:Caf1), carrying the Ala9Val, Ala11Val, and Leu13Val mutations in the Gd donor strand | | Descriptor: | Chaperone protein caf1M, F1 capsule antigen | | Authors: | Fooks, L.J, Yu, X, Moslehi-Mohebi, E, Tischenko, V, Knight, S.D, MacIntyre, S, Zavialov, A.V. | | Deposit date: | 2008-07-07 | | Release date: | 2009-07-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Hydrophobicity and rigidity of binding segments enable CAF1M chaperone to act as assembly catalyst
To be published
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3DSN
 | | Crystal structure of the complex of the Caf1M chaperone with the mini-fiber of two Caf1 subunits (Caf1:Caf1), carrying the Thr7Phe mutation in the Gd donor strand | | Descriptor: | Chaperone protein caf1M, F1 capsule antigen | | Authors: | Fooks, L.J, Yu, X, Moslehi-Mohebi, E, Tischenko, V, Knight, S.D, MacIntyre, S, Zavialov, A.V. | | Deposit date: | 2008-07-13 | | Release date: | 2009-07-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Hydrophobicity and rigidity of binding segments enable CAF1M chaperone to act as assembly catalyst
To be Published
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2LPJ
 | | NMR structure of major ampullate spidroin 1 N-terminal domain at pH 7.2 | | Descriptor: | Major ampullate spidroin 1 | | Authors: | Jaudzems, K, Nordling, K, Landreh, M, Rising, A, Askarieh, G, Knight, S.D, Johansson, J. | | Deposit date: | 2012-02-14 | | Release date: | 2012-06-27 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | pH-Dependent Dimerization of Spider Silk N-Terminal Domain Requires Relocation of a Wedged Tryptophan Side Chain.
J.Mol.Biol., 422, 2012
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2LPI
 | | NMR structure of a monomeric mutant (A72R) of major ampullate spidroin 1 N-terminal domain | | Descriptor: | Major ampullate spidroin 1 | | Authors: | Jaudzems, K, Nordling, K, Landreh, M, Rising, A, Askarieh, G, Knight, S.D, Johansson, J. | | Deposit date: | 2012-02-14 | | Release date: | 2012-06-27 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | pH-Dependent Dimerization of Spider Silk N-Terminal Domain Requires Relocation of a Wedged Tryptophan Side Chain.
J.Mol.Biol., 422, 2012
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3L08
 | | Structure of Pi3K gamma with a potent inhibitor: GSK2126458 | | Descriptor: | 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | Authors: | Elkins, P.A, Marrero, E.M. | | Deposit date: | 2009-12-09 | | Release date: | 2010-06-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
ACS Med Chem Lett, 1, 2010
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3L54
 | | Structure of Pi3K gamma with inhibitor | | Descriptor: | 6-(1H-pyrazolo[3,4-b]pyridin-5-yl)-4-pyridin-4-ylquinoline, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | Authors: | Elkins, P.A, Smallwood, A.M. | | Deposit date: | 2009-12-21 | | Release date: | 2010-06-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
ACS Med Chem Lett, 1, 2010
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7ZL4
 | | Cryo-EM structure of archaic chaperone-usher Csu pilus of Acinetobacter baumannii | | Descriptor: | CsuA/B | | Authors: | Pakharukova, N, Malmi, H, Tuittila, M, Paavilainen, S, Ghosal, D, Chang, Y.W, Jensen, G.J, Zavialov, A.V. | | Deposit date: | 2022-04-13 | | Release date: | 2022-08-03 | | Last modified: | 2022-09-21 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Archaic chaperone-usher pili self-secrete into superelastic zigzag springs.
Nature, 609, 2022
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1QUN
 | | X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI | | Descriptor: | MANNOSE-SPECIFIC ADHESIN FIMH, PAPD-LIKE CHAPERONE FIMC | | Authors: | Choudhury, D, Thompson, A, Stojanoff, V, Langerman, S, Pinkner, J, Hultgren, S.J, Knight, S. | | Deposit date: | 1999-07-01 | | Release date: | 1999-08-31 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli.
Science, 285, 1999
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3FCG
 | | Crystal Structure Analysis of the Middle Domain of the Caf1A Usher | | Descriptor: | CHLORIDE ION, F1 capsule-anchoring protein | | Authors: | Yu, X, Visweswaran, G.R, Duck, Z, Marupakula, S, MacIntyre, S, Knight, S, Zavialov, A.V. | | Deposit date: | 2008-11-21 | | Release date: | 2008-12-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Caf1A usher possesses a Caf1 subunit-like domain that is crucial for Caf1 fibre secretion
Biochem.J., 418, 2009
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2LTH
 | | NMR structure of major ampullate spidroin 1 N-terminal domain at pH 5.5 | | Descriptor: | Major ampullate spidroin 1 | | Authors: | Otikovs, M, Jaudzems, K, Nordling, K, Landreh, M, Rising, A, Askarieh, G, Knight, S, Johansson, J. | | Deposit date: | 2012-05-25 | | Release date: | 2013-11-27 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation.
Nat Commun, 5, 2014
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4YKN
 | | Pi3K alpha lipid kinase with Active Site Inhibitor | | Descriptor: | 3-(6-methoxypyridin-3-yl)-5-[({4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}amino)methyl]benzoic acid, Phosphatidylinositol 3-kinase regulatory subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform fusion protein | | Authors: | Elkins, P.A. | | Deposit date: | 2015-03-04 | | Release date: | 2015-06-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Discovery of a Potent Class of PI3K alpha Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
Acs Med.Chem.Lett., 6, 2015
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6FJY
 | | Crystal structure of CsuC-CsuE chaperone-tip adhesion subunit pre-assembly complex from archaic chaperone-usher Csu pili of Acinetobacter baumannii | | Descriptor: | CsuC, Protein CsuE | | Authors: | Pakharukova, N.A, Tuitilla, M, Paavilainen, S, Zavialov, A.V. | | Deposit date: | 2018-01-23 | | Release date: | 2018-05-16 | | Last modified: | 2018-09-19 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Structural basis forAcinetobacter baumanniibiofilm formation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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