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FGFR1 kinase domain complex with fragment 2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamide
Descriptor:	2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide, Fibroblast growth factor receptor 1
Authors:	Paik, W.-K, Squire, C.J.
Deposit date:	2017-02-05
Release date:	2017-02-22
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Fragment screening diverse active sites To Be Published

FGFR1 kinase domain complex with SN37333 in reversible binding mode
Descriptor:	3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, Fibroblast growth factor receptor 1
Authors:	Yosaatmadja, Y, Paik, W.-K, Smaill, J.B, Squire, C.J.
Deposit date:	2017-02-09
Release date:	2017-05-31
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors. Eur J Med Chem, 135, 2017