7R8V
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![BU of 7r8v by Molmil](/molmil-images/mine/7r8v) | Cryo-EM structure of the ADP state actin filament | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Gong, R, Espinosa de los Reyes, S, Reynolds, M.J, Gurel, P, Alushin, G.M. | Deposit date: | 2021-06-27 | Release date: | 2021-07-28 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7RB9
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![BU of 7rb9 by Molmil](/molmil-images/mine/7rb9) | Cryo-EM structure of the rigor state Jordan myosin-15-F-actin complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. | Deposit date: | 2021-07-05 | Release date: | 2021-07-28 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7R91
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![BU of 7r91 by Molmil](/molmil-images/mine/7r91) | cryo-EM structure of the rigor state wild type myosin-15-F-actin complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. | Deposit date: | 2021-06-28 | Release date: | 2021-07-28 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7RB8
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![BU of 7rb8 by Molmil](/molmil-images/mine/7rb8) | cryo-EM structure of the ADP state wild type myosin-15-F-actin complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. | Deposit date: | 2021-07-05 | Release date: | 2021-07-28 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7UDT
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![BU of 7udt by Molmil](/molmil-images/mine/7udt) | cryo-EM structure of the rigor state wild type myosin-15-F-actin complex (symmetry expansion and re-centering) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Gong, R, Reynolds, M.J, Alushin, G.M. | Deposit date: | 2022-03-20 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7UDU
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![BU of 7udu by Molmil](/molmil-images/mine/7udu) | cryo-EM structure of the ADP state wild type myosin-15-F-actin complex (symmetry expansion and re-centering) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Gong, R, Reynolds, M.J, Alushin, G.M. | Deposit date: | 2022-03-20 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (4.15 Å) | Cite: | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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3R7W
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![BU of 3r7w by Molmil](/molmil-images/mine/3r7w) | Crystal Structure of Gtr1p-Gtr2p complex | Descriptor: | GTP-binding protein GTR1, GTP-binding protein GTR2, MAGNESIUM ION, ... | Authors: | Gong, R, Li, L, Liu, Y, Wang, P, Yang, H, Wang, L, Cheng, J, Guan, K.L, Xu, Y. | Deposit date: | 2011-03-23 | Release date: | 2011-08-24 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (2.773 Å) | Cite: | Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation Genes Dev., 25, 2011
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6KBH
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![BU of 6kbh by Molmil](/molmil-images/mine/6kbh) | Crystal structure of an intact type IV self-sufficient cytochrome P450 monooxygenase | Descriptor: | Cytochrome P450 monooxygenase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | Authors: | Gong, R, Wu, L.J, Zhang, Y, Liu, Z, Dou, S, Zhang, R.G, Xu, J.H, Tang, C, Zhou, J.H. | Deposit date: | 2019-06-25 | Release date: | 2020-07-01 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of an intact type IV self-sufficient cytochrome P450 monooxygenase To Be Published
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7KCH
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![BU of 7kch by Molmil](/molmil-images/mine/7kch) | Myosin XI-F-actin complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Gong, R, Alushin, G.M. | Deposit date: | 2020-10-05 | Release date: | 2021-01-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.33 Å) | Cite: | Optical control of fast and processive engineered myosins in vitro and in living cells. Nat.Chem.Biol., 17, 2021
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5IAY
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![BU of 5iay by Molmil](/molmil-images/mine/5iay) | NMR structure of UHRF1 Tandem Tudor Domains in a complex with Spacer peptide | Descriptor: | E3 ubiquitin-protein ligase UHRF1, Spacer | Authors: | Fang, J, Cheng, J, Wang, J, Zhang, Q, Liu, M, Gong, R, Wang, P, Zhang, X, Feng, Y, Lan, W, Gong, Z, Tang, C, Wong, J, Yang, H, Cao, C, Xu, Y. | Deposit date: | 2016-02-22 | Release date: | 2016-04-20 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition Nat Commun, 7, 2016
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4YOC
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![BU of 4yoc by Molmil](/molmil-images/mine/4yoc) | Crystal Structure of human DNMT1 and USP7/HAUSP complex | Descriptor: | DNA (cytosine-5)-methyltransferase 1, Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION | Authors: | Cheng, J, Yang, H, Fang, J, Gong, R, Wang, P, Li, Z, Xu, Y. | Deposit date: | 2015-03-11 | Release date: | 2015-05-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.916 Å) | Cite: | Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun, 6, 2015
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5C56
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![BU of 5c56 by Molmil](/molmil-images/mine/5c56) | Crystal structure of USP7/HAUSP in complex with ICP0 | Descriptor: | Ubiquitin E3 ligase ICP0, Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Cheng, J, Li, Z, Gong, R, Fang, J, Yang, Y, Sun, C, Yang, H, Xu, Y. | Deposit date: | 2015-06-19 | Release date: | 2015-07-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.685 Å) | Cite: | Molecular mechanism for the substrate recognition of USP7. Protein Cell, 6, 2015
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7SX8
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![BU of 7sx8 by Molmil](/molmil-images/mine/7sx8) | T-Plastin-F-actin complex, parallel bundled state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Mei, L, Reynolds, M.J, Alushin, G.M. | Deposit date: | 2021-11-22 | Release date: | 2022-08-31 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Structural mechanism for bidirectional actin cross-linking by T-plastin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7SX9
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![BU of 7sx9 by Molmil](/molmil-images/mine/7sx9) | T-Plastin-F-actin complex, anti-parallel bundled state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Mei, L, Reynolds, M.J, Alushin, G.M. | Deposit date: | 2021-11-22 | Release date: | 2022-08-31 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Structural mechanism for bidirectional actin cross-linking by T-plastin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7SXA
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![BU of 7sxa by Molmil](/molmil-images/mine/7sxa) | T-Plastin-F-actin complex, pre-bundling intermediate state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Mei, L, Reynolds, M.J, Alushin, G.M. | Deposit date: | 2021-11-22 | Release date: | 2022-08-31 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (6.87 Å) | Cite: | Structural mechanism for bidirectional actin cross-linking by T-plastin. Proc.Natl.Acad.Sci.USA, 119, 2022
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6NZV
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![BU of 6nzv by Molmil](/molmil-images/mine/6nzv) | Crystal structure of HCV NS3/4A protease in complex with compound 12 | Descriptor: | (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide, HCV NS3/4A protease, SULFATE ION, ... | Authors: | Appleby, T.C, Taylor, J.G. | Deposit date: | 2019-02-14 | Release date: | 2019-07-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®. Bioorg.Med.Chem.Lett., 29, 2019
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7R94
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![BU of 7r94 by Molmil](/molmil-images/mine/7r94) | T-Plastin-F-actin complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Mei, L, Alushin, G.M. | Deposit date: | 2021-06-28 | Release date: | 2022-07-06 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural mechanism for bidirectional actin cross-linking by T-plastin. Proc.Natl.Acad.Sci.USA, 119, 2022
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8VB1
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![BU of 8vb1 by Molmil](/molmil-images/mine/8vb1) | Crystal structure of HIV-1 protease with GS-9770 | Descriptor: | (2S)-2-{(3M)-4-chloro-3-[1-(difluoromethyl)-1H-1,2,4-triazol-5-yl]phenyl}-2-[(2E,4R)-4-[4-(2-cyclopropyl-2H-1,2,3-triazol-4-yl)phenyl]-2-imino-5-oxo-4-(3,3,3-trifluoro-2,2-dimethylpropyl)imidazolidin-1-yl]ethyl [1-(difluoromethyl)cyclopropyl]carbamate, HIV-1 protease | Authors: | Lansdon, E.B. | Deposit date: | 2023-12-11 | Release date: | 2024-03-06 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. Antimicrob.Agents Chemother., 68, 2024
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7FAT
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![BU of 7fat by Molmil](/molmil-images/mine/7fat) | Structure Determination of the RBD-NB1A7 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, nb_1A7 | Authors: | Geng, Y, Shi, Z.Z, Li, X.Y, Wang, L, Sun, Z.C, Zhang, H.W, Chen, X.C. | Deposit date: | 2021-07-07 | Release date: | 2022-05-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural basis of nanobodies neutralizing SARS-CoV-2 variants Structure, 30, 2022
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7FAU
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![BU of 7fau by Molmil](/molmil-images/mine/7fau) | Structure Determination of the NB1B11-RBD Complex | Descriptor: | NB_1B11, Spike protein S1, ZINC ION | Authors: | Shi, Z.Z, Li, X.X, Wang, L, Sun, Z.C, Zhang, H.W, Chen, X.C, Cui, Q.Q, Qiao, H.R, Lan, Z.Y, Zhang, X. | Deposit date: | 2021-07-07 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural basis of nanobodies neutralizing SARS-CoV-2 variants. Structure, 30, 2022
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7FH5
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![BU of 7fh5 by Molmil](/molmil-images/mine/7fh5) | Structure of AdaV | Descriptor: | AdaV, CHLORIDE ION, FE (III) ION | Authors: | Zhang, Z.Y, Chen, W.Q, Zhai, G.Q, Zhang, M. | Deposit date: | 2021-07-29 | Release date: | 2022-08-03 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis Acs Catalysis, 12, 2022
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3N9M
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![BU of 3n9m by Molmil](/molmil-images/mine/3n9m) | ceKDM7A from C.elegans, alone | Descriptor: | FE (II) ION, Putative uncharacterized protein, ZINC ION | Authors: | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | Deposit date: | 2010-05-31 | Release date: | 2010-06-30 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.493 Å) | Cite: | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res., 20, 2010
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3N9P
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![BU of 3n9p by Molmil](/molmil-images/mine/3n9p) | ceKDM7A from C.elegans, complex with H3K4me3K27me2 peptide and NOG | Descriptor: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | Authors: | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | Deposit date: | 2010-05-31 | Release date: | 2010-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.388 Å) | Cite: | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res., 20, 2010
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8D14
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![BU of 8d14 by Molmil](/molmil-images/mine/8d14) | Helical ADP-Pi-F-actin | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Reynolds, M.J, Alushin, G.M. | Deposit date: | 2022-05-26 | Release date: | 2022-09-07 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
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8D18
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![BU of 8d18 by Molmil](/molmil-images/mine/8d18) | Straight ADP-F-actin 2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Reynolds, M.J, Alushin, G.M. | Deposit date: | 2022-05-26 | Release date: | 2022-09-07 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
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