2F7Z
| Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine | Descriptor: | (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE, PKI, inhibitory peptide, ... | Authors: | Li, Q, Woods, K.W, Thomas, S, Zhu, G.D, Packard, G, Fisher, J, Li, T, Gong, J, Dinges, J, Song, X, Abrams, J, Luo, Y, Johnson, E.F, Shi, Y, Liu, X, Klinghofer, V, Des Jong, R, Oltersdorf, T, Stoll, V.S, Jakob, C.G, Rosenberg, S.H, Giranda, V.L. | Deposit date: | 2005-12-01 | Release date: | 2006-06-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg.Med.Chem.Lett., 16, 2006
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5ZHP
| M3 muscarinic acetylcholine receptor in complex with a selective antagonist | Descriptor: | (1R,2R,4S,5S,7s)-7-({[4-fluoro-2-(thiophen-2-yl)phenyl]carbamoyl}oxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-9-ium, CITRIC ACID, HEXAETHYLENE GLYCOL, ... | Authors: | Liu, H, Hofmann, J, Fish, I, Schaake, B, Eitel, K, Bartuschat, A, Kaindl, J, Rampp, H, Banerjee, A, Hubner, H, Clark, M.J, Vincent, S.G, Fisher, J, Heinrich, M, Hirata, K, Liu, X, Sunahara, R.K, Shoichet, B.K, Kobilka, B.K, Gmeiner, P. | Deposit date: | 2018-03-13 | Release date: | 2018-11-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2F7E
| PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine | Descriptor: | (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE, PKI inhibitory peptide, cAMP-dependent protein kinase, ... | Authors: | Stoll, V.S. | Deposit date: | 2005-11-30 | Release date: | 2006-06-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg.Med.Chem.Lett., 16, 2006
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1B53
| NMR STRUCTURE OF HUMAN MIP-1A D26A, MINIMIZED AVERAGE STRUCTURE | Descriptor: | MIP-1A | Authors: | Waltho, J.P, Higgins, L.D, Craven, C.J, Tan, P, Dudgeon, T. | Deposit date: | 1999-01-11 | Release date: | 1999-07-22 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants. J.Biol.Chem., 274, 1999
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1B50
| NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES | Descriptor: | MIP-1A | Authors: | Waltho, J.P, Higgins, L.D, Craven, C.J, Tan, P, Dudgeon, T. | Deposit date: | 1999-01-11 | Release date: | 1999-07-22 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants. J.Biol.Chem., 274, 1999
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6S3S
| Structure of the FliPQR complex from the flagellar type 3 secretion system of Vibrio mimicus. | Descriptor: | Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, Flagellar biosynthetic protein FliR | Authors: | Kuhlen, L, Johnson, S, Deme, J.C, Lea, S.M. | Deposit date: | 2019-06-25 | Release date: | 2020-03-25 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion. Nat Commun, 11, 2020
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6S3L
| Structure of the core of the flagellar export apparatus from Vibrio mimicus, the FliPQR-FlhB complex. | Descriptor: | Flagellar biosynthetic protein FlhB, Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, ... | Authors: | Kuhlen, L, Johnson, S, Deme, J.C, Lea, S.M. | Deposit date: | 2019-06-25 | Release date: | 2020-03-25 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion. Nat Commun, 11, 2020
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6S3R
| Structure of the FliPQR complex from the flagellar type 3 secretion system of Pseudomonas savastanoi. | Descriptor: | Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, Flagellar biosynthetic protein FliR | Authors: | Kuhlen, L, Johnson, S, Deme, J.C, Lea, S.M. | Deposit date: | 2019-06-25 | Release date: | 2020-03-25 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion. Nat Commun, 11, 2020
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